Acyl-coenzyme A dehydrogenase (PA2815)

Identification
Name: Acyl-coenzyme A dehydrogenase
Synonyms:
  • ACDH
Gene Name: fadE
Enzyme Class: Not Available
Biological Properties
General Function: Involved in acyl-CoA dehydrogenase activity
Specific Function: Catalyzes the dehydrogenation of acyl-CoA
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
FAD + Octanoyl-CoA ↔ FADH2 + (2E)-Octenoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
FAD + Palmityl-CoA ↔ FADH2 + (2E)-Hexadecenoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
FAD + Tetradecanoyl-CoA ↔ FADH2 + (2E)-Tetradecenoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
FAD + Hexanoyl-CoA ↔ FADH2 + trans-2-Hexenoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Lauroyl-CoA + FAD ↔ (2E)-Dodecenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Decanoyl-CoA (N-C10:0CoA) + FAD ↔ (2E)-Decenoyl-CoA + FADH2
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Butanoyl-CoA+Thumb ↔ Thumb+Thumb
Butanoyl-CoA + FAD ↔ FADH2 + Crotonoyl-CoA
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Thumb+Thumb ↔ Thumb+Thumb
Palmityl-CoA + FAD ↔ (2E)-Hexadecenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Octanoyl-CoA + FAD ↔ (2E)-Octenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Lauroyl-CoA + FAD ↔ (2E)-Dodecenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Tetradecanoyl-CoA + FAD ↔ (2E)-Tetradecenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Hexanoyl-CoA + FAD ↔ trans-2-Hexenoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
Decanoyl-CoA (N-C10:0CoA) + FAD ↔ (2E)-Decenoyl-CoA + FADH2
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
a 2,3,4-saturated fatty acyl CoA+ETF-Oxidized → a trans-2-enoyl-CoA+ETF-Reduced
a 2,3,4-saturated fatty acyl CoA + ETF-Oxidized → a trans-2-enoyl-CoA + ETF-Reduced
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Complex Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Butyryl-CoA + FAD ↔ Crotonoyl-CoA + FADH2
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Thumb+Thumb ↔ Thumb+Thumb
FAD + Stearoyl-CoA ↔ FADH2 + Trans-Octadec-2-enoyl-CoA
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000543(2E)-Decenoyl-CoAMetaboCard
PAMDB000522(2E)-Dodecenoyl-CoAMetaboCard
PAMDB000541(2E)-Hexadecenoyl-CoAMetaboCard
PAMDB000544(2E)-Octenoyl-CoAMetaboCard
PAMDB000542(2E)-Tetradecenoyl-CoAMetaboCard
PAMDB000250Butyryl-CoAMetaboCard
PAMDB000429Crotonoyl-CoAMetaboCard
PAMDB000670Decanoyl-CoA (N-C10:0CoA)MetaboCard
PAMDB000308FADMetaboCard
PAMDB000293FADH2MetaboCard
PAMDB000467Hexanoyl-CoAMetaboCard
PAMDB000516Lauroyl-CoAMetaboCard
PAMDB000241Octanoyl-CoAMetaboCard
PAMDB000343Palmityl-CoAMetaboCard
PAMDB001690Stearoyl-CoAMetaboCard
PAMDB000409Tetradecanoyl-CoAMetaboCard
PAMDB000540trans-2-Hexenoyl-CoAMetaboCard
PAMDB001759Trans-Octadec-2-enoyl-CoAMetaboCard
GO Classification:
Function
acyl-CoA dehydrogenase activity
adenyl nucleotide binding
binding
catalytic activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
purine nucleoside binding
Process
carboxylic acid metabolic process
cellular metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
fatty acid catabolic process
fatty acid metabolic process
metabolic process
monocarboxylic acid metabolic process
organic acid metabolic process
oxidation reduction
oxoacid metabolic process
Gene Properties
Locus tag: PA2815
Strand: +
Entrez Gene ID: 882805
Accession: NP_251505.1
GI: 15598011
Sequence start: 3168106
Sequence End: 3170553
Sequence Length: 2447
Gene Sequence: 
>PA2815
ATGTTGTTGCTCTGGTTAGTCGTACTGGTACTCGGTGTCGCTTACCTCGCCCATCGGCGTACCCCACCCGCTCCCGCGCTCGGCATCAGCGCCGCCTACCTGATCCTGATGGGCGTGTTCAGCCACGCGCCCGGCTGGCTGCTGCTGGTCTTCTGGCTGCTCTGGCTGGCGGTGGCGCTTCCCCTCGCCCTGCCCGACCTGCGCCGGCGCGTGCTCAGCGGTCCGCTGTTCGCCTGGTTCCAGAAAGTCCTGCCGCCGATGTCCGACACCGAGCGCGAGGCCATCGAGGCGGGCACCGTGTGGTGGGATGGCGAATTGTTCAGCGGCCGCCCGGACTGGCAGAAACTGCTCGACTACCCCAAGGCGCAACTCACCGAAGAAGAGCAGGCCTTCGTCGACGGCCCGACCGAAGAACTCTGCGCCATGGTCAGCGACTGGGACATCGGCCAGCGCATGGACCTGCCGGAAGAAGCCTGGGCCTTCATCAAGCAGCACGGCTTCTTCGGCCTGATCATTCCCAAGGAGTACGGCGGCAAGGGCTTCTCCGCCTTCGCCCACTCGCAGGTAGTGATGAAGCTCGCCACCCGTAGCGGCGACCTGGCCTCGACGGTGATGGTGCCGAACTCCCTCGGCCCGGCCGAGCTGCTGCTCCACTACGGCACCGACGAGCAGCGCCAGCGCTACCTGCCGAGCCTGGCCAAGGGCGACGACATCCCCTGCTTCGCCCTCACCGGCCCCTACGCGGGCTCCGATGCCGGCGGCATGACCGACGTCGGCATCGTCTGCAAGGGCGAATGGGAAGGTCGCGAGGTGCTCGGCCTGCGCCTGACCTGGGAAAAGCGCTACATCACCCTCGGCCCGGTGGCCACCCTCCTCGGCCTGGCCTTCAAGTGCCACGACCCGGACCATCTGCTGGGCGACGAGGAGGACCTGGGCATCACCCTGGCGCTGATTCCCACCGACACCCCCGGGGTCGAGATCGGCCGCCGCCACGTGCCGCTGGGCGCCGCCTTCATGAACGGTCCGAACTCCGGCAAGGACGTGTTCGTGCCGCTGGAGTACATCATCGGCGGGCAGGAAATGATCGGCAAAGGCTGGATGATGCTGATGAACTGCCTGTCGGTCGGACGCTCCATCTCGCTGCCGGCGGTGGGCACCAGCGCTGGCAAGGCCAGCAGCTACGTCAGCGGTCGCTACGCTCAGGTCCGCGAGCAGTTCAACGTGCCGATCGCCGCCTTCGAAGGCATCCAGGAGGCGCTCGCCCGCATCGGCGGCAACGCCTGGCTGATGGACAGCGCGCGAATCCTCACCGCCAACGCGGTGGACCTCGGCGAGAAGCCCTCGGTGCTTTCGGCGATCCTCAAGTACCACCTCACCGAGCGCGGCCGCGAGTGCATCGCCCATGCCATGGACATCCATGGCGGCAAGGGCATCATCATGGGCCCGAACAACTACCTGGGTCGTTCCTGGCAGGGCGCGCCGATCTTCATCACGGTGGAAGGCGCGAACATCCTCTCGCGCAACCTGATGATCTTCGGCCAGGGCGCGATCCGTTGCCATCCGTACGTACTCAAGGAAATGGAACTGGCCCAGCGCGAGGACAAGGACCAGGCCGCCCGCGAGTTCGACGCGCTGCTGGTGAAGCACATCGGCTTCGCCGTCGGCAACGCCGCCAGCAGCTTCCTCCTCAGTCTCAGCTGCGGCCACCTCGGCAACGCGCCCGGCGACCGCATCAGCCGTCCCTACTTCCGCGCGCTGAACCGCCTGGCGGCGTCCTTCGCCCTGCTCGCCGACTTCAGCATGATGCTGCTGGGCGGCGAACTGAAGCGCAAGGAACGCCTCTCCGCGCGTCTCGGCGATGTCCTCAGCTATCTCTACCTGGGCTCGGCGGCGCTCAAGCGCTACCACGACCTGGGCAACCCGGACTACCTGCATCCGCTGCTGCGCTGGGCCATGGAGGAAAACCTCGGCAAGGCCGAGGCGGCGCTGGAGGACCTGCTGAACAACTTCCCCAGCCGCTTCTTCGGCTGCGCGCTGAAGGTCCTGGTACTGCCGTTCGGCCGCCGGCACAAAGGGCCGGGCGACGAACTGGACGCCGAGATCGCGGAAATCCTCGGCCGTCCGGACGACGACCCGGCGTTGCAGGCGATCCTCGCTGGCGCGTTCCTGCCGAAGGACCCGCAGGACCCGGTCGGTGCCCTCGCCCACGCCTTCGACGCGGTACGCGAAAGCGCCGCGCTGGAGAAAACCCTGCACAAGGCGATCAAGGAAGGCAGGGTCCAGCCGCAAGCGGGGCAGAACCCGATCGATGCCGGCGCCGCCGCCGGCGTGCTGAGCGCCGAGCAGGCGCAGGCCCTGCACCAGGCCGAAGCGGCACGGCGCAAGGTGATCGACGTCGACGACTTCGCCAAGGAGGAACTGCAACTGGCCGACGGCAGGATCCGCTGA
Protein Properties
Protein Residues: 815
Protein Molecular Weight: 88.8 kDa
Protein Theoretical pI: 5.92
Hydropathicity (GRAVY score): 0.03
Charge at pH 7 (predicted): -12.42
Protein Sequence: 
>PA2815
MLLLWLVVLVLGVAYLAHRRTPPAPALGISAAYLILMGVFSHAPGWLLLVFWLLWLAVALPLALPDLRRRVLSGPLFAWFQKVLPPMSDTEREAIEAGTVWWDGELFSGRPDWQKLLDYPKAQLTEEEQAFVDGPTEELCAMVSDWDIGQRMDLPEEAWAFIKQHGFFGLIIPKEYGGKGFSAFAHSQVVMKLATRSGDLASTVMVPNSLGPAELLLHYGTDEQRQRYLPSLAKGDDIPCFALTGPYAGSDAGGMTDVGIVCKGEWEGREVLGLRLTWEKRYITLGPVATLLGLAFKCHDPDHLLGDEEDLGITLALIPTDTPGVEIGRRHVPLGAAFMNGPNSGKDVFVPLEYIIGGQEMIGKGWMMLMNCLSVGRSISLPAVGTSAGKASSYVSGRYAQVREQFNVPIAAFEGIQEALARIGGNAWLMDSARILTANAVDLGEKPSVLSAILKYHLTERGRECIAHAMDIHGGKGIIMGPNNYLGRSWQGAPIFITVEGANILSRNLMIFGQGAIRCHPYVLKEMELAQREDKDQAAREFDALLVKHIGFAVGNAASSFLLSLSCGHLGNAPGDRISRPYFRALNRLAASFALLADFSMMLLGGELKRKERLSARLGDVLSYLYLGSAALKRYHDLGNPDYLHPLLRWAMEENLGKAEAALEDLLNNFPSRFFGCALKVLVLPFGRRHKGPGDELDAEIAEILGRPDDDPALQAILAGAFLPKDPQDPVGALAHAFDAVRESAALEKTLHKAIKEGRVQPQAGQNPIDAGAAAGVLSAEQAQALHQAEAARRKVIDVDDFAKEELQLADGRIR
References
External Links:
Resource Link
Genome ID: PA2815
Entrez Gene ID: 882805
NCBI Protein ID: 15598011
General Reference: PaperBLAST - Find papers about PA2815 and its homologs