S-(hydroxymethyl)glutathione dehydrogenase (PA3629)

Identification
Name: S-(hydroxymethyl)glutathione dehydrogenase
Synonyms:
  • Alcohol dehydrogenase class-3
  • Alcohol dehydrogenase class-III
  • Glutathione-dependent formaldehyde dehydrogenase
  • FALDH
  • FDH
  • GSH-FDH
Gene Name: frmA
Enzyme Class:
Biological Properties
General Function: Involved in zinc ion binding
Specific Function: Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Ethanol + NAD ↔ Acetaldehyde + Hydrogen ion + NADH
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
S-(Hydroxymethyl)glutathione + NAD ↔ S-Formylglutathione + Hydrogen ion + NADH
ReactionCard
Primary alcohol+Thumb ↔ Aldehyde+Thumb+Thumb
Primary alcohol + NAD ↔ Aldehyde + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Ethanol + NAD ↔ Acetaldehyde + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Retinol + NAD ↔ Retinal + NADH + Hydrogen ion
ReactionCard
trans-3-Chloro-2-propene-1-ol+Thumb ↔ trans-3-Chloroallyl aldehyde+Thumb+Thumb
trans-3-Chloro-2-propene-1-ol + NAD ↔ trans-3-Chloroallyl aldehyde + NADH + Hydrogen ion
ReactionCard
cis-3-Chloro-2-propene-1-ol+Thumb ↔ cis-3-Chloroallyl aldehyde+Thumb+Thumb
cis-3-Chloro-2-propene-1-ol + NAD ↔ cis-3-Chloroallyl aldehyde + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
(2-Naphthyl)methanol + NAD ↔ 2-Naphthaldehyde + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
S-(Hydroxymethyl)glutathione + NAD ↔ S-Formylglutathione + NADH + Hydrogen ion
ReactionCard
Chloral hydrate+Thumb+Thumb ↔ Trichloroethanol+Thumb+Thumb
Chloral hydrate + NADH + Hydrogen ion ↔ Trichloroethanol + NAD + Water
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
2-Phenyl-1,3-propanediol monocarbamate + NAD ↔ 3-Carbamoyl-2-phenylpropionaldehyde + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one + NAD ↔ 5-Phenyl-1,3-oxazinane-2,4-dione + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
S-(Hydroxymethyl)glutathione + NAD + NADP ↔ S-Formylglutathione + NADH + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
(2-Naphthyl)methanol + NAD → 2-Naphthaldehyde + Hydrogen ion + NADH
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Ethanol + NAD ↔ Acetaldehyde + Hydrogen ion + NADH
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Ethanol + NAD ↔ Acetaldehyde + NADH + Hydrogen ion
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
D-Glyceraldehyde + Hydrogen ion + NADH ↔ Glycerol + NAD
ReactionCard
Thumb+NAD(P)(+) → Thumb+NAD(P)H
S-(Hydroxymethyl)glutathione + NAD(P)(+) → S-Formylglutathione + NAD(P)H
ReactionCard
An alcohol+Thumb → an aldehyde or ketone+Thumb
An alcohol + NAD → an aldehyde or ketone + NADH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000856(2-Naphthyl)methanolMetaboCard
PAMDB0008701-HydroxymethylnaphthaleneMetaboCard
PAMDB0008962-NaphthaldehydeMetaboCard
PAMDB0008972-Phenyl-1,3-propanediol monocarbamateMetaboCard
PAMDB0001313,4-DihydroxyphenylglycolMetaboCard
PAMDB0009143-Carbamoyl-2-phenylpropionaldehydeMetaboCard
PAMDB0009394-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-oneMetaboCard
PAMDB0009555-Phenyl-1,3-oxazinane-2,4-dioneMetaboCard
PAMDB000217AcetaldehydeMetaboCard
PAMDB002040AldehydeMetaboCard
PAMDB000233D-GlyceraldehydeMetaboCard
PAMDB000041EthanolMetaboCard
PAMDB000050GlycerolMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB002049RetinalMetaboCard
PAMDB002050RetinolMetaboCard
PAMDB000659S-(Hydroxymethyl)glutathioneMetaboCard
PAMDB000417S-FormylglutathioneMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
S-(hydroxymethyl)glutathione dehydrogenase activity
transition metal ion binding
zinc ion binding
Process
alcohol metabolic process
ethanol metabolic process
ethanol oxidation
metabolic process
monohydric alcohol metabolic process
oxidation reduction
small molecule metabolic process
Gene Properties
Locus tag: PA3629
Strand: -
Entrez Gene ID: 880459
Accession: NP_252319.1
GI: 15598825
Sequence start: 4063875
Sequence End: 4064987
Sequence Length: 1112
Gene Sequence: 
>PA3629
ATGATCAAGTCCCGTGCCGCCGTCGCCTTCGCCCCCAACAAGCCGTTGGAAATCGTCGAGGTGGATGTGGCGCCGCCGCAGAAGGGCGAGGTACTGGTGCGCATCGTCGCCACCGGCGTCTGCCATACCGACGCGTACACCCTGTCCGGCCAGGATTCCGAGGGGGTGTTCCCGTGCATCCTGGGCCACGAAGGTGGCGGCATCGTCGAAGCGGTGGGCGAGGGCGTGACCTCCCTGCAGGTGGGCGACCATGTCATCCCGCTCTACACCGCCGAGTGCGGCAAGTGCAAATTCTGCCTGTCCGGCAAGACCAACCTCTGCCAGGCCGTGCGCGCCACCCAGGGCAAGGGCCTGATGCCCGACGGCACCAGCCGTTTCTCCTACAAGGGCGAGCCGGTCTTCCACTACATGGGCTGCTCGACCTTCTCCGAATACACCGTGCTGCCGGAAATCTCCCTGGCGAAGATTCCCAAGGATGCCCCGCTGGAGAAGGTCTGCCTGCTTGGCTGCGGCGTCACCACCGGGATCGGTGCCGTGCTGAACACCGCCAAGGTGGAAGAGGGCGCTACCGTTGCCATCTTCGGCCTGGGCGGCATCGGCCTGGCAGCGATCATCGGGGCGAAGATGGCCAAGGCCGCGCGCATCATCGCGGTCGACATCAACCCGGGCAAGTTCGATATCGCCAGGGAACTGGGCGCCACCGACTTCATCAATCCGAAGGACTACGACAAGCCGATCCAGGACGTCATCGTCGAACTGACCGATGGCGGCGTCGACTACTCCTTCGAGTGCGTCGGCAACGTGCAGTTGATGCGCGCCGCGCTGGAATGCTGCCACAAGGGCTGGGGCGAGTCGGTGATCATCGGTGTCGCCGGTGCCGGCCAGGAAATCAGCACCCGGCCGTTCCAACTGGTCACCGGCCGCGTCTGGCGCGGTTCGGCGTTCGGCGGGGTGCGCGGGCGCAGCGAGCTGCCGAGCTATGTCGAGAAGGCGCAGAAGGGCGAGATCCCGCTGGATACCTTCATCACCCACACCATGGGGCTGGAGGACATCAACGAGGCCTTCGAGCTGATGCACGAAGGCAAGAGCATCCGCACCGTCATTCATTACTGA
Protein Properties
Protein Residues: 370
Protein Molecular Weight: 39.2 kDa
Protein Theoretical pI: 5.44
Hydropathicity (GRAVY score): 0.134
Charge at pH 7 (predicted): -7.43
Protein Sequence: 
>PA3629
MIKSRAAVAFAPNKPLEIVEVDVAPPQKGEVLVRIVATGVCHTDAYTLSGQDSEGVFPCILGHEGGGIVEAVGEGVTSLQVGDHVIPLYTAECGKCKFCLSGKTNLCQAVRATQGKGLMPDGTSRFSYKGEPVFHYMGCSTFSEYTVLPEISLAKIPKDAPLEKVCLLGCGVTTGIGAVLNTAKVEEGATVAIFGLGGIGLAAIIGAKMAKAARIIAVDINPGKFDIARELGATDFINPKDYDKPIQDVIVELTDGGVDYSFECVGNVQLMRAALECCHKGWGESVIIGVAGAGQEISTRPFQLVTGRVWRGSAFGGVRGRSELPSYVEKAQKGEIPLDTFITHTMGLEDINEAFELMHEGKSIRTVIHY
References
External Links:
Resource Link
Genome ID: PA3629
Entrez Gene ID: 880459
NCBI Protein ID: 15598825
General Reference: PaperBLAST - Find papers about PA3629 and its homologs