Record Information
Version 1.0
Update Date 1/22/2018 12:54:54 PM
Metabolite IDPAMDB000050
Identification
Name: Glycerol
Description:Glycerol is an organic compound, also called glycerin or glycerine. It is a colorless, odorless, viscous liquid that is widely used in pharmaceutical formulations. Glycerol has three hydrophilic hydroxyl groups that are responsible for its solubility in water and its hygroscopic nature. Metabolism of glycerol in Pseudomonas aeruginosa, generally requires the presence of external electron acceptors. The respiratory pathways mediating this metabolic process involve a glycerol transporter (encoded by glpF), a glycerol kinase (encoded by glpK), and two respiratory glycerol-3-phosphate dehydrogenases (G3PDHs). Glycerol may also be metabolized fermentatively leading to the production of ethanol.
Structure
Thumb
Synonyms:
  • 1,2,3-Trihydroxypropane
  • 1,2,3-Trihydroxypropanol
  • Bulbold
  • Cristal
  • E 422
  • Emery 916
  • Glyceol Opthalgan
  • Glycerin
  • Glycerine
  • Glyceritol
  • Glycerol
  • Glycyl alcohol
  • Glyrol
  • Glysanin
  • IFP
  • Incorporation factor
  • Mackstat H 66
  • Osmoglyn
  • Pricerine 9091
  • Propanetriol
  • RG-S
  • Trihydroxypropane
  • Tryhydroxypropane
Chemical Formula: C3H8O3
Average Molecular Weight: 92.0938
Monoisotopic Molecular Weight: 92.047344122
InChI Key: PEDCQBHIVMGVHV-UHFFFAOYSA-N
InChI:InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
CAS number: 56-81-5
IUPAC Name:propane-1,2,3-triol
Traditional IUPAC Name: glycerol
SMILES:OCC(O)CO
Chemical Taxonomy
Taxonomy DescriptionThis compound belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
Kingdom Organic compounds
Super ClassOrganooxygen compounds
Class Carbohydrates and carbohydrate conjugates
Sub ClassSugar alcohols
Direct Parent Sugar alcohols
Alternative Parents
Substituents
  • Sugar alcohol
  • Secondary alcohol
  • Polyol
  • 1,2-diol
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular Framework Aliphatic acyclic compounds
External Descriptors
Physical Properties
State: Liquid
Charge:0
Melting point: 20
Experimental Properties:
PropertyValueSource
Water Solubility:1000.0 mg/mL [YALKOWSKY,SH & DANNENFELSER,RM (1992)]PhysProp
LogP:-1.76 [HANSCH,C ET AL. (1995)]PhysProp
Predicted Properties
PropertyValueSource
Water Solubility1170.0 mg/mLALOGPS
logP-1.9ALOGPS
logP-1.8ChemAxon
logS1.1ALOGPS
pKa (Strongest Acidic)13.61ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area60.69 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity20.52 m3·mol-1ChemAxon
Polarizability8.93 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations: Cytoplasm
Reactions:
Glycerol + NAD > Dihydroxyacetone + NADH
PS(14:0/18:1(11Z)) > Glycerol + a cardiolipin
PG(18:0/18:0) + PG(18:0/18:0) > Glycerol + CL(16:0/16:0/16:0/16:1(9Z))
PG(18:2(9Z,12Z)/18:2(9Z,12Z)) > CL(18:2(9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z)/18:2(9Z,12Z)) + Glycerol
2 PG(18:1(9Z)/18:1(9Z)) > Glycerol + CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(9Z))
PG(14:0(3-OH)/15:0) > Glycerol + CL(15:0cyclo/15:0cyclo/14:0/16:0)
PG(14:0/14:0) > Glycerol + cardiolipin (tetratetradecanoyl, n-C14:0)
PG(14:0/16:0) > CL(14:0/16:0/14:0/16:0) + Glycerol
2 PG(16:1(9Z)/16:1(9Z)) > Glycerol + cardiolipin (tetrahexadec-9-enoyl, n-C16:1)
PG(19:0cycv8c/19:iso) > Glycerol + CL(19:0cycv8c/19:0cycv8c/19:0cycv8c/19:0cycv8c)
PG(15:0/16:1) > Glycerol + CL(15:0cyclo/15:0cyclo/15:0cyclo/15:0cyclo)
2 PG(10:0/19:iso) > Glycerol + CL(19:0cycv8c/14:0/14:0/17:0cycw7c)
2 PG(10:0/19:iso) > Glycerol + CL(19:0cycv8c/14:0/17:0cycw7c/14:0)
2 PG(16:0/14:0) > Glycerol + CL(19:0cycv8c/14:0/14:0/19:0cycv8c)
2 PG(16:0/14:0) > CL(19:0cycv8c/14:0/19:0cycv8c/14:0) + Glycerol
2 PG(16:0/14:0) > Glycerol + CL(19:0cycv8c/15:0cyclo/15:0cyclo/17:0cycw7c)
2 PG(16:0/14:0) > Glycerol + CL(19:0cycv8c/15:0cyclo/17:0cycw7c/15:0cyclo)
2 PG(10:0/19:iso) > Glycerol + CL(19:0cycv8c/17:0cycw7c/14:0/14:0)
2 PG(16:0/14:0) > Glycerol + CL(19:0cycv8c/19:0cycv8c/14:0/14:0)
2 PG(16:0/14:0) > Glycerol + CL(17:0cycw7c/18:1(9Z)/17:0cycw7c/14:0)
2 PG(10:0/19:iso) > Glycerol + CL(17:0cycw7c/19:0cycv8c/14:0/14:0)
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/14:0/14:0/18:1(9Z))
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/14:0/17:0cycw7c/17:0cycw7c)
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/14:0/18:1(9Z)/14:0)
2 PG(14:0/14:0) > Glycerol + CL(18:1(9Z)/15:0cyclo/14:0/15:0cyclo)
2 PG(14:0/14:0) > Glycerol + CL(18:1(9Z)/15:0cyclo/15:0cyclo/14:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/15:0cyclo/18:1(9Z)/15:0cyclo)
2 PG(14:0/14:0) > Glycerol + CL(18:1(9Z)/16:0/14:0/14:0)
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/16:0/14:0/16:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/16:0/14:0/18:1(9Z))
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/16:0/18:1(9Z)/14:0)
2 PG(14:0/14:0) > Glycerol + CL(18:1(9Z)/16:1(9Z)/14:0/14:0)
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/16:1(9Z)/14:0/16:1(9Z))
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/16:1(9Z)/14:0/18:1(9Z))
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/16:1(9Z)/16:1(9Z)/14:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/16:1(9Z)/18:1(9Z)/14:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/17:0cycw7c/14:0/17:0cycw7c)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/17:0cycw7c/17:0cycw7c/14:0)
2 PG(10:0/19:iso) > Glycerol + CL(18:1(9Z)/18:1(9Z)/14:0/14:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/18:1(9Z)/14:0/16:0)
2 PG(16:0/14:0) > Glycerol + CL(18:1(9Z)/18:1(9Z)/14:0/16:1(9Z))
2 PG(10:0/19:iso) > Glycerol + CL(17:0cycw7c/16:1(9Z)/14:0/17:0cycw7c)
2 PG(10:0/19:iso) > Glycerol + CL(17:0cycw7c/16:1(9Z)/17:0cycw7c/14:0)
2 PG(16:0/14:0) > Glycerol + CL(17:0cycw7c/16:1(9Z)/17:0cycw7c/16:1(9Z))
2 PG(10:0/19:iso) > Glycerol + CL(17:0cycw7c/17:0cycw7c/14:0/16:0)
2 PG(10:0/19:iso) > Glycerol + CL(17:0cycw7c/17:0cycw7c/14:0/16:1(9Z))
2 PG(16:0/14:0) > Glycerol + CL(17:0cycw7c/18:1(9Z)/14:0/17:0cycw7c)
2 PG(16:1(9Z)/12:0(3-OH)) > Glycerol + CL(18:1(9Z)/15:0cyclo/14:0/15:0cyclo)
2 PG(14:0(3-OH)/14:0) > Glycerol + CL(18:1(9Z)/15:0cyclo/14:0/15:0cyclo)
2 PG(18:1(9Z)/16:0) > Glycerol + CL(18:1(9Z)/16:0/18:1(9Z)/16:0)
2 PG(18:1(9Z)/16:1(9Z)) > Glycerol + CL(18:1(9Z)/16:1(9Z)/18:1(9Z)/16:1(9Z))
Glycerol + Adenosine triphosphate > Hydrogen ion + Adenosine diphosphate + Glycerol 3-phosphate + ADP
2 PG(10:0(3-OH)/10:0) > Glycerol + CL(10:0(3-OH)/10:0/10:0(3-OH)/10:0)
2 PG(10:0(3-OH)/12:0(3-OH)) > Glycerol + CL(10:0(3-OH)/12:0(3-OH)/10:0(3-OH)/12:0(3-OH))
2 PG(10:0(3-OH)/12:0) > Glycerol + CL(10:0(3-OH)/12:0/10:0(3-OH)/12:0)
2 PG(10:0(3-OH)/15:0cyclo) > CL(10:0(3-OH)/15:0cyclo/10:0(3-OH)/15:0cyclo) + Glycerol
2 PG(10:0(3-OH)/16:0) > CL(10:0(3-OH)/16:0/10:0(3-OH)/16:0) + Glycerol
2 PG(10:0(3-OH)/16:1(9Z)) > Glycerol + CL(10:0(3-OH)/16:1(9Z)/10:0(3-OH)/16:1(9Z))
2 PG(10:0(3-OH)/17:0cycw7c) > Glycerol + CL(10:0(3-OH)/17:0cycw7c/10:0(3-OH)/17:0cycw7c)
2 PG(10:0(3-OH)/19:0cycv8c) > Glycerol + CL(10:0(3-OH)/19:0cycv8c/10:0(3-OH)/19:0cycv8c)
2 PG(10:0(3-OH)/19:iso) > Glycerol + CL(10:0(3-OH)/19:iso/10:0(3-OH)/19:iso)
2 PG(10:0/10:0(3-OH)) > Glycerol + CL(10:0/10:0(3-OH)/10:0/10:0(3-OH))
2 PG(10:0/12:0(3-OH)) > Glycerol + CL(10:0/12:0(3-OH)/10:0/12:0(3-OH))
2 PG(12:0(3-OH)/10:0(3-OH)) > Glycerol + CL(12:0(3-OH)/10:0(3-OH)/12:0(3-OH)/10:0(3-OH))
2 PG(12:0(3-OH)/10:0) > Glycerol + CL(12:0(3-OH)/10:0/12:0(3-OH)/10:0)
2 PG(12:0(3-OH)/14:0(3-OH)) > CL(12:0(3-OH)/14:0(3-OH)/12:0(3-OH)/14:0(3-OH)) + Glycerol
2 PG(12:0(3-OH)/14:0) > Glycerol + CL(12:0(3-OH)/14:0/12:0(3-OH)/14:0)
2 PG(12:0(3-OH)/15:0) > CL(12:0(3-OH)/15:0/12:0(3-OH)/15:0) + Glycerol
2 PG(12:0(3-OH)/15:0cyclo) > Glycerol + CL(12:0(3-OH)/15:0cyclo/12:0(3-OH)/15:0cyclo)
2 PG(12:0(3-OH)/17:0cycw7c) > Glycerol + CL(12:0(3-OH)/17:0cycw7c/12:0(3-OH)/17:0cycw7c)
2 PG(12:0(3-OH)/18:1(9Z)) > Glycerol + CL(12:0(3-OH)/18:1(9Z)/12:0(3-OH)/18:1(9Z))
2 PG(12:0(3-OH)/19:0cycv8c) > Glycerol + CL(12:0(3-OH)/19:0cycv8c/12:0(3-OH)/19:0cycv8c)
2 PG(12:0(3-OH)/19:iso) > Glycerol + CL(12:0(3-OH)/19:iso/12:0(3-OH)/19:iso)
2 PG(12:0/10:0(3-OH)) > CL(12:0/10:0(3-OH)/12:0/10:0(3-OH)) + Glycerol
2 PG(12:0/12:0) > Glycerol + cardiolipin (tetradodecanoyl, n-C12:0)
2 PG(12:0/14:0(3-OH)) > Glycerol + CL(12:0/14:0(3-OH)/12:0/14:0(3-OH))
2 PG(12:0/19:iso) > Glycerol + CL(12:0/19:iso/12:0/19:iso)
2 PG(14:0(3-OH)/12:0(3-OH)) > CL(14:0(3-OH)/12:0(3-OH)/14:0(3-OH)/12:0(3-OH)) + Glycerol
2 PG(14:0(3-OH)/12:0) > Glycerol + CL(14:0(3-OH)/12:0/14:0(3-OH)/12:0)
2 PG(14:0(3-OH)/16:1(9Z)) > Glycerol + CL(14:0(3-OH)/16:1(9Z)/14:0(3-OH)/16:1(9Z))
2 PG(14:0(3-OH)/17:0cycw7c) > Glycerol + CL(14:0(3-OH)/17:0cycw7c/14:0(3-OH)/17:0cycw7c)
2 PG(14:0/12:0(3-OH)) > Glycerol + CL(14:0/12:0(3-OH)/14:0/12:0(3-OH))
2 PG(15:0/10:0(3-OH)) > Glycerol + CL(15:0/10:0(3-OH)/15:0/10:0(3-OH))
2 PG(15:0/12:0(3-OH)) > Glycerol + CL(15:0/12:0(3-OH)/15:0/12:0(3-OH))
2 PG(15:0cyclo/10:0(3-OH)) > Glycerol + CL(15:0cyclo/10:0(3-OH)/15:0cyclo/10:0(3-OH))
2 PG(16:0/10:0(3-OH)) > Glycerol + CL(16:0/10:0(3-OH)/16:0/10:0(3-OH))
2 PG(16:0/14:0(3-OH)) > Glycerol + CL(16:0/14:0(3-OH)/16:0/14:0(3-OH))
2 PG(16:1(9Z)/14:0(3-OH)) > Glycerol + CL(16:1(9Z)/14:0(3-OH)/16:1(9Z)/14:0(3-OH))
2 PG(17:0cycw7c/10:0(3-OH)) > Glycerol + CL(17:0cycw7c/10:0(3-OH)/17:0cycw7c/10:0(3-OH))
2 PG(17:0cycw7c/12:0(3-OH)) > Glycerol + CL(17:0cycw7c/12:0(3-OH)/17:0cycw7c/12:0(3-OH))
More...

Pathways:
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-0fr2-0910000000-6497c0870b71585c6322View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-0ktb-0920000000-93408d69acffad6f48afView in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-05mk-0940000000-778ba583836705f8fdf4View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)splash10-00kb-0920000000-2e4b358941c660851f0aView in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-00dj-6920000000-6828d7b00cb31e84fac1View in MoNA
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-0le9-0940000000-e0b9bada9be26d720326View in MoNA
GC-MSGC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0a4i-9000000000-d7c139dc01453f61eb99View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0a4l-9000000000-7d7844b4813b038012daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0udi-9100000000-16029dbe79f139ab904aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positivesplash10-01ox-9000000000-3fe0c184a891364773a8View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0006-9000000000-a638e26fe3c3f48563c2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-004l-9000000000-d3fd9e9abd911eb0f88eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a6r-9000000000-ca218dca3a5d86196d81View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-9000000000-b40367f5ca8d11288fbeView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0006-9000000000-ba29a0647084e32d8704View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0abc-9000000000-4cd85379d414c16f95c0View in MoNA
MSMass Spectrum (Electron Ionization)splash10-01ox-9000000000-3706109441e6d3017895View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,1H] 2D NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
References:
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  • Sjostrand M, Gudbjornsdottir S, Holmang A, Strindberg L, Ekberg K, Lonnroth P: Measurements of interstitial muscle glycerol in normal and insulin-resistant subjects. J Clin Endocrinol Metab. 2002 May;87(5):2206-11. Pubmed: 11994365
  • Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
  • Sweatman BC, Farrant RD, Holmes E, Ghauri FY, Nicholson JK, Lindon JC: 600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances. J Pharm Biomed Anal. 1993 Aug;11(8):651-64. Pubmed: 8257730
  • Titov VN, Lisitsyn DM, Ameliushkina VA, Lupanov VP, Staroverov II, Osipov SG, Kukharchuk VV: [Double bonds of fatty acids, alcohols glycerol, cholesterol and nonpolar serum lipids. Diagnostic value of hypercholesterolemia] Klin Lab Diagn. 2002 May;(5):3-8. Pubmed: 12085703
  • van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. Pubmed: 17765195
  • Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. Pubmed: 18331064
  • Yaqoob M, Nabi A: Flow injection chemiluminescent assays for glycerol and triglycerides using a co-immobilized enzyme reactor. Luminescence. 2003 Mar-Apr;18(2):67-71. Pubmed: 12687625
Synthesis Reference: Yang, Yifang. Purification of glycerol. Faming Zhuanli Shenqing Gongkai Shuomingshu (2007), 3pp.
Material Safety Data Sheet (MSDS) Download (PDF)
External Links:
ResourceLink
CHEBI ID17754
HMDB IDHMDB00131
Pubchem Compound ID753
Kegg IDC00116
ChemSpider ID733
WikipediaGlycerol
BioCyc IDGLYCEROL
EcoCyc IDGLYCEROL
Ligand ExpoGOL

Enzymes

General function:
Involved in glycerophosphodiester phosphodiesterase activity
Specific function:
Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols
Gene Name:
glpQ
Locus Tag:
PA0347
Molecular weight:
42 kDa
Reactions
A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate.
General function:
Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:
Key enzyme in the regulation of glycerol uptake and metabolism
Gene Name:
glpK
Locus Tag:
PA3582
Molecular weight:
56 kDa
Reactions
ATP + glycerol = ADP + sn-glycerol 3-phosphate.
General function:
Involved in phosphatidylinositol phosphorylation
Specific function:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Gene Name:
suhB
Locus Tag:
PA3818
Molecular weight:
29.5 kDa
Reactions
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters
Gene Name:
aphA
Locus Tag:
PA1409
Molecular weight:
38 kDa
Reactions
A phosphate monoester + H(2)O = an alcohol + phosphate.
General function:
Involved in zinc ion binding
Specific function:
Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates
Gene Name:
frmA
Locus Tag:
PA3629
Molecular weight:
39.2 kDa
Reactions
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
An alcohol + NAD(+) = an aldehyde or ketone + NADH.
General function:
Involved in phosphotransferase activity, for other substituted phosphate groups
Specific function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Affects resistance to the gyrase inhibitor novobiocin
Gene Name:
cls
Locus Tag:
PA5394
Molecular weight:
54.6 kDa
Reactions
2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
General function:
Involved in catalytic activity
Specific function:
Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. Catalyzes little, if any, cardiolipin synthesis in vivo, even when the expression level is very high
Gene Name:
ybhO
Locus Tag:
PA2155
Molecular weight:
46.5 kDa
Reactions
2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.

Transporters

General function:
Involved in transporter activity
Specific function:
Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols
Gene Name:
glpF
Locus Tag:
PA3581
Molecular weight:
28.9 kDa