Reaction Details
Reaction: Thumb
2 ATP + hydrogen carbonate + ammonium → 2 ADP + carbamoyl-phosphate + phosphate + 2 H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:RXN-13202
References:
  • Anderson PM, Meister A (1965). "Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase." Biochemistry 4(12);2803-9. PMID: 5326356
  • Holden HM, Thoden JB, Raushel FM (1998). "Carbamoyl phosphate synthetase: a tunnel runs through it." Curr Opin Struct Biol 8(6);679-85. PMID: 9914247
  • Kalman SM, Duffield PH, Brzozowski T (1966). "Purification and properties of a bacterial carbamyl phosphate synthetase." J Biol Chem 241(8);1871-7. PMID: 5329589
  • Raushel FM, Thoden JB, Reinhart GD, Holden HM (1998). "Carbamoyl phosphate synthetase: a crooked path from substrates to products." Curr Opin Chem Biol 2(5);624-32. PMID: 9818189
  • Raushel FM, Thoden JB, Holden HM (1999). "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia." Biochemistry 38(25);7891-9. PMID: 10387030
  • Stapleton MA, Javid-Majd F, Harmon MF, Hanks BA, Grahmann JL, Mullins LS, Raushel FM (1996). "Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase." Biochemistry 35(45);14352-61. PMID: 8916922
  • Thoden JB, Huang X, Raushel FM, Holden HM (2002). "Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia." J Biol Chem 277(42);39722-7. PMID: 12130656
  • Yip MC, Knox WE (1970). "Glutamine-dependent carbamyl phosphate synthetase. Properties and distribution in normal and neoplastic rat tissues." J Biol Chem 245(9);2199-204. PMID: 5442268