Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (PA5312)

Identification
Name: Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
Synonyms:
  • Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase
Gene Name: puuC
Enzyme Class: Not Available
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Involved in the breakdown of putrescine. Was previously shown to have a weak but measurable ALDH enzyme activity that prefers NADP over NAD as coenzyme
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+2 Thumb+Thumb
gamma-Glutamyl-gamma-butyraldehyde + Water + NADP ↔ 4-(Glutamylamino) butanoate + 2 Hydrogen ion + NADPH
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
gamma-Glutamyl-gamma-butyraldehyde + NAD + Water ↔ 4-(Glutamylamino) butanoate + NADH + Hydrogen ion
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
gamma-Glutamyl-gamma-butyraldehyde + NADP + Water ↔ 4-(Glutamylamino) butanoate + NADPH + Hydrogen ion
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SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+2 Thumb+NADPH+Thumb
4-(γ-glutamylamino)butanal + Water + NADP → 4-(Glutamylamino) butanoate + 2 Hydrogen ion + NADPH + NADPH
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Thumb+Thumb+Thumb → gamma-glutamyl-gamma-aminobutyrate+Thumb+2 Thumb
gamma-Glutamyl-gamma-butyraldehyde + NADP + Water → gamma-glutamyl-gamma-aminobutyrate + NADPH + 2 Hydrogen ion
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PseudoCyc/BioCyc Reactions:
NAD(P)++Thumb+Thumb → Thumb+NAD(P)H+Thumb
NAD(P)+ + gamma-Glutamyl-gamma-butyraldehyde + Water → 4-(Glutamylamino) butanoate + NAD(P)H + Hydrogen ion
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3-hydroxypropionaldehyde+Thumb+Thumb → Thumb+Thumb+Thumb
3-hydroxypropionaldehyde + NAD + Water → Hydrogen ion + 3-Hydroxypropanoate + NADH
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Complex Reactions:
Thumb+Thumb+Thumb → Thumb+2 Thumb+Thumb
Acetaldehyde + Water + NAD → Acetic acid + 2 Hydrogen ion + NADH
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Thumb+NAD(P)(+)+Thumb → a carboxylate+NAD(P)H
Aldehyde + NAD(P)(+) + Water → a carboxylate + NAD(P)H
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Transports: Not Available
Metabolites:
PAMDB IDNameView
3-HydroxypropanoateMetaboCard
PAMDB0008244-(Glutamylamino) butanoateMetaboCard
PAMDB0063094-(γ-glutamylamino)butanalMetaboCard
PAMDB000217AcetaldehydeMetaboCard
PAMDB000012Acetic acidMetaboCard
PAMDB002040AldehydeMetaboCard
PAMDB001737gamma-Glutamyl-gamma-butyraldehydeMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA5312
Strand: -
Entrez Gene ID: 877979
Accession: NP_253999.1
GI: 15600505
Sequence start: 5982097
Sequence End: 5983590
Sequence Length: 1493
Gene Sequence: 
>PA5312
ATGACCACCCTGACCCGCGCCGACTGGGAAGCCCGCGCCAAAGACCTGAAGATCGAAGGCCGTGCCTTCGTCAACGGCGAATACAGCAACGCCGCCTCCGGCGAGACCTTCGATTGCCTGAGCCCGGTGGATGGCCGCTTCCTGGCCAAGGTCGCCAGTTGCGACCTGGCCGATGCCGAGCAGGCGGTCAAGGTCGCCCGCAATGCCTTCGATTCCGGCGCCTGGTCGCGCCTGGCGCCGGCCAAGCGCAAGCAGACGATGATCCGCTTCGCCGATCTGCTGCTGGAGAACGCCGAGGAGCTGGCCCTGCTGGAAACCCTGGACATGGGCAAGCCGATCAGCGACTCGCTGCACATCGACGTCGCCAGCGCCGCCAACAGCCTGCGCTGGAGCGCCGAGGCGATCGACAAGATCTATGACGAAGTCGCCGCCACTCCCCATGCCGAGCTGGGCCTGGTGACCCGCGAGCCGGTCGGCGTGGTCGCCGCCATCGTGCCGTGGAACTTCCCGCTGCTGATGTCCTGCTGGAAACTCGGTCCGGCCCTGGCCACCGGCAACTCGGTGATCCTCAAGCCCTCCGAGAAGTCGCCGCTGACCGCCATCCGCATCGCCCAGCTGGCCGTCGAGGCCGGCATTCCGAAAGGCGTGTTCAACGTGCTGCCGGGCTATGGCCACACGGTAGGCAAGGCGCTGGCATTGCACATGGATGTCGACACCCTGGTGTTCACCGGTTCGACCAAGATCGCCAAGCAACTGATGGTCTATGCCGGCGAGTCGAACATGAAGCGCGTCTGGCTGGAGGCCGGCGGCAAGAGCCCGAACATCGTCTTCGCCGACGCCCCGGACCTGAAGGCCGCCGCCGAAGCCGCTGCCGGCGCCATCGCCTTCAACCAGGGCGAAGTCTGCACCGCCGGTTCGCGCCTGCTGGTGGAGCGCTCCATCAAGGACAAGTTCCTGCCCCTGGTGATCGAGGCCCTCAAGGGCTGGAAACCGGGCAACCCGCTGGATCCGGAAACCAACGTCGGCGCGCTGGTGGACACCCAGCAGATGAACACCGTGCTGTCCTACATCGAGGCCGGTCACAACGACGGCGCCAAGCTGGTCGCCGGCGGCAAGCGGACCCTGGAAGAAACTGGTGGCACCTACGTCGAGCCGACTATCTTCGACGGCGTGACCAATGCGATGAAGATCGCCCGCGAGGAAATCTTCGGCCCGGTGCTCTCGGTGATCGAGTTCGAGGATGCCGAGGAAGCCGTGCGCATCGCCAACGACACGCCCTATGGGCTGGCGGCGGCGGTCTGGACCAGCAACCTGTCCAAGGCGCACCTGACTGCCAAGGCCCTGCGCGCCGGCAGCGTCTGGGTCAACCAGTACGACGGCGGCGACATGACCGCTCCGTTCGGCGGCTTCAAGCAGTCGGGCAACGGTCGCGACAAGTCGCTGCACGCCTTCGACAAGTACACCGAGCTGAAGGCGACCTGGATCAAGCTCTGA
Protein Properties
Protein Residues: 497
Protein Molecular Weight: 53.1 kDa
Protein Theoretical pI: 5.25
Hydropathicity (GRAVY score): -0.025
Charge at pH 7 (predicted): -8.41
Protein Sequence: 
>PA5312
MTTLTRADWEARAKDLKIEGRAFVNGEYSNAASGETFDCLSPVDGRFLAKVASCDLADAEQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISDSLHIDVASAANSLRWSAEAIDKIYDEVAATPHAELGLVTREPVGVVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKALALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKATWIKL
References
External Links:
Resource Link
Genome ID: PA5312
Entrez Gene ID: 877979
NCBI Protein ID: 15600505
General Reference: PaperBLAST - Find papers about PA5312 and its homologs