Beta-hexosaminidase (PA3005)

Identification
Name: Beta-hexosaminidase
Synonyms:
  • Beta-N-acetylhexosaminidase
  • N-acetyl-beta-glucosaminidase
Gene Name: nagZ
Enzyme Class:
Biological Properties
General Function: Involved in beta-N-acetylhexosaminidase activity
Specific Function: Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ 2 Thumb
Chitobiose + Water ↔ 2 N-Acetyl-D-glucosamine
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Thumb+Globoside ↔ Thumb+Globotriaosylceramide
Water + Globoside ↔ N-Acetyl-b-D-galactosamine + Globotriaosylceramide
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GM2+Thumb ↔ GM3+Thumb
GM2 + Water ↔ GM3 + N-Acetyl-b-D-galactosamine
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G13033+Thumb ↔ G08421+Thumb
G13033 + Water ↔ G08421 + N-Acetyl-b-D-galactosamine
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G06780+Thumb ↔ G08421+Thumb
G06780 + Water ↔ G08421 + N-Acetyl-b-D-galactosamine
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SMPDB Reactions:
Thumb+Chitobiose+Thumb → 2 N-Acetyl-D-glucosamine+2 Thumb
Water + Chitobiose + Chitobiose → 2 N-Acetyl-D-glucosamine + 2 N-Acetylglucosamine
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N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate+Thumb → Thumb+anhydro-n-acetylmuramic acid
N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + Water → N-Acetylglucosamine + anhydro-n-acetylmuramic acid
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PseudoCyc/BioCyc Reactions:
an N-acetyl-β-D-hexosaminide+Thumb ? an organic molecule+an N-acetyl-β-D-hexosamine
an N-acetyl-β-D-hexosaminide + Water ? an organic molecule + an N-acetyl-β-D-hexosamine
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N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate+Thumb ? Thumb+Thumb
N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + Water ? N-Acetyl-D-glucosamine + 1,6-Anhydro-N-acetylmuramate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid + Water → N-Acetyl-D-glucosamine + 1,6-Anhydro-N-acetylmuramate
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Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide + Water → N-Acetyl-D-glucosamine + 1,6-Anhydrous-N-Acetylmuramyl-tetrapeptide
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Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide + Water → N-Acetyl-D-glucosamine + 1,6-Anhydrous-N-Acetylmuramyl-tripeptide
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0013271,6-Anhydro-N-acetylmuramateMetaboCard
PAMDB0015201,6-Anhydrous-N-Acetylmuramyl-tetrapeptideMetaboCard
PAMDB0015211,6-Anhydrous-N-Acetylmuramyl-tripeptideMetaboCard
PAMDB000515ChitobioseMetaboCard
PAMDB000193N-Acetyl-b-D-galactosamineMetaboCard
PAMDB000088N-Acetyl-D-glucosamineMetaboCard
PAMDB001656N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acidMetaboCard
PAMDB001657N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptideMetaboCard
PAMDB001658N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptideMetaboCard
PAMDB001956N-AcetylglucosamineMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing O-glycosyl compounds
Process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Locus tag: PA3005
Strand: -
Entrez Gene ID: 880216
Accession: NP_251695.1
GI: 15598201
Sequence start: 3365756
Sequence End: 3366754
Sequence Length: 998
Gene Sequence: 
>PA3005
ATGCAAGGCTCTCTGATGCTCGACATCGGCGGCACCTGGCTGACCGCCGAGGACCGCCAAATCCTGCGCCACCCCGAGGTGGGCGGGCTGATCATCTTCGCTCGCAACATCGAGCATCCTGCCCAGGTTCGCGAACTGTGTGCGGCCATTCGCGCCATCCGTCCCGACCTGTTGCTGGCCGTCGACCAGGAAGGAGGGCGCGTGCAGCGCCTGCGCCAGGGCTTCGTGCGCCTGCCGGCGATGCGCGCGATCGCCGACAACCCCAATGCCGAAGAGCTGGCCGAGCATTGTGGCTGGCTGATGGCGACCGAGGTGCAGGCGGTCGGCCTCGACCTGAGTTTCGCGCCGGTGCTGGATCTCGATCACCAGCGCAGCGCCGTGGTCGGTAGCCGCGCCTTCGAGGGCGACCCGGAGCGTGCCGCGCTGCTTGCCGGTGCTTTCATTCGCGGCATGCATGCCGCCGGGATGGCCGCCACCGGCAAGCATTTTCCCGGTCACGGCTGGGCCGAGGCCGATTCCCATGTGGCGATTCCCGAAGACGCGCGCAGTCTCGAGGAAATCCGGCGCAGCGACCTGGTTCCGTTCGCCCGCCTGGCCGGACAGCTCGACGCGCTGATGCCGGCCCATGTCATCTATCCGCAGGTCGACCCGCAGCCCGCCGGCTTTTCCCGGCGCTGGTTGCAGGAGATCCTGCGCGGCGAGCTGAAGTTCGACGGGGTGATATTCAGCGACGACCTGTCGATGGCCGGCGCCCATGTGGTCGGCGACGCCGCCAGCCGCATCGAGGCCGCCCTGGCCGCGGGCTGCGACATGGGCCTGGTGTGCAACGACCGGGCTTCCGCCGAGCTGGCCCTGGCTGCCCTGCAACGCCTGAAGGTGACCCCGCCGTCGCGTCTGCAACGCATGCGTGGCAAGGGCTACGCGAATACCGACTATCGCCAGCAGCCGCGCTGGCTGGAAGCACTGTCCGCGTTGCGCGCTGCGCAACTGATTGATTGA
Protein Properties
Protein Residues: 332
Protein Molecular Weight: 36.1 kDa
Protein Theoretical pI: 6.18
Hydropathicity (GRAVY score): -0.068
Charge at pH 7 (predicted): -4.7
Protein Sequence: 
>PA3005
MQGSLMLDIGGTWLTAEDRQILRHPEVGGLIIFARNIEHPAQVRELCAAIRAIRPDLLLAVDQEGGRVQRLRQGFVRLPAMRAIADNPNAEELAEHCGWLMATEVQAVGLDLSFAPVLDLDHQRSAVVGSRAFEGDPERAALLAGAFIRGMHAAGMAATGKHFPGHGWAEADSHVAIPEDARSLEEIRRSDLVPFARLAGQLDALMPAHVIYPQVDPQPAGFSRRWLQEILRGELKFDGVIFSDDLSMAGAHVVGDAASRIEAALAAGCDMGLVCNDRASAELALAALQRLKVTPPSRLQRMRGKGYANTDYRQQPRWLEALSALRAAQLID
References
External Links:
Resource Link
Genome ID: PA3005
Entrez Gene ID: 880216
NCBI Protein ID: 15598201
General Reference: PaperBLAST - Find papers about PA3005 and its homologs