Spermidine synthase (PA1687)

Identification
Name: Spermidine synthase
Synonyms:
  • Putrescine aminopropyltransferase
  • PAPT
  • SPDSY
Gene Name: speE
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
S-Adenosylmethioninamine + Putrescine + Ethylenediamine ↔ 5'-Methylthioadenosine + Hydrogen ion + Spermidine
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Thumb+Thumb → Thumb+Thumb+Thumb
Cadaverine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Hydrogen ion + Aminopropylcadaverine
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Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethioninamine + Putrescine ↔ 5'-Methylthioadenosine + Spermidine
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Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethioninamine + Spermidine ↔ 5'-Methylthioadenosine + Spermine
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Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethioninamine + Cadaverine ↔ 5'-Methylthioadenosine + Aminopropylcadaverine
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SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+5'-S-methyl-5'-thioadenosine
Putrescine + S-Adenosylmethioninamine → Spermidine + Hydrogen ion + 5'-S-methyl-5'-thioadenosine
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Thumb+Thumb → Thumb+Thumb+Thumb
Cadaverine + Decarboxy-SAM → Aminopropylcadaverine + 5'-Methylthioadenosine + Hydrogen ion
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Thumb+Thumb → Thumb+Thumb+Thumb
Decarboxy-SAM + Putrescine → 5'-Methylthioadenosine + Spermidine + Hydrogen ion
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
S-Adenosylmethioninamine + Putrescine + Ethylenediamine ↔ 5'-Methylthioadenosine + Hydrogen ion + Spermidine
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Thumb+Thumb → Thumb+Thumb+Thumb
Cadaverine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Hydrogen ion + Aminopropylcadaverine
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Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethioninamine + Putrescine ↔ 5'-Methylthioadenosine + Spermidine
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
S-Adenosylmethioninamine + Putrescine → 5'-Methylthioadenosine + Spermidine
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002825'-MethylthioadenosineMetaboCard
PAMDB000827AminopropylcadaverineMetaboCard
PAMDB000457CadaverineMetaboCard
PAMDB001159Decarboxy-SAMMetaboCard
PAMDB001114EthylenediamineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000378PutrescineMetaboCard
PAMDB000216S-AdenosylmethioninamineMetaboCard
PAMDB000312SpermidineMetaboCard
PAMDB000311SpermineMetaboCard
GO Classification:
Function
catalytic activity
Gene Properties
Locus tag: PA1687
Strand: +
Entrez Gene ID: 883061
Accession: NP_250378.1
GI: 15596884
Sequence start: 1836367
Sequence End: 1837227
Sequence Length: 860
Gene Sequence: 
>PA1687
ATGAGCGATTATCAGGAAACTCTGTACCAGGGCTACGGCCAGCGCTTCAGCATCGACAACATGCTGCATGAGGTGCGCACCGAGCACCAGCACCTGGTGATTTTCGAAAACGCCCGGATGGGCCGGGTGATGGCGCTCGATGGAGTGATCCAGACCACCGAGGCCGACGAGTTCATCTACCACGAGATGCTCACCCACGTGCCGATCCTCGCCCACGGCGCGGCCCGGCGCGTGCTGATCATCGGCGGCGGCGACGGTGGCATGCTGCGCGAGGTGGCCAAGCACAAGAGCGTCGAGCGGATCACCATGGTCGAGATCGACGGCACCGTGGTCGACATGTGCAAGGAGTTCCTGCCCAACCACTCCCAGGGCGCCTTCGACGACCCGCGGCTGAACCTGGTGATCGACGACGGCATGCGCTTCGTGGCTACCACGGAAGAACGCTTCGACGTGATCATCTCCGACTCCACCGACCCGATCGGCCCTGGCGAGGTGCTGTTCTCCGAGAACTTCTACCAGGCCTGCCGGCGCTGCCTGAACGAGGGTGGCATCCTGGTCACCCAGAACGGCACGCCGTTCATGCAACTGGAGGAAGTGCGCACCACCGCCGCACGTACCGACGGGCTGTTTGCCGACTGGCATTTCTACCAGGCGGCGGTGCCGACCTATATCGGCGGCGCCATGACCTTCGCCTGGGGTTCGACCCACGAAGGCCTGCGTCGCCTTCCGCTGGAAACGCTGCGCCAGCGCTTCCGCGACAGCGGCATCGCCACCCGCTACTACAACGCCGATATCCACCTGGGCGCGTTTGCTCTGCCGCAGTACGTGCTGCAGGCCATCGGCAAGCAGGACAACGACTGA
Protein Properties
Protein Residues: 286
Protein Molecular Weight: 32.2 kDa
Protein Theoretical pI: 4.93
Hydropathicity (GRAVY score): -0.239
Charge at pH 7 (predicted): -12.44
Protein Sequence: 
>PA1687
MSDYQETLYQGYGQRFSIDNMLHEVRTEHQHLVIFENARMGRVMALDGVIQTTEADEFIYHEMLTHVPILAHGAARRVLIIGGGDGGMLREVAKHKSVERITMVEIDGTVVDMCKEFLPNHSQGAFDDPRLNLVIDDGMRFVATTEERFDVIISDSTDPIGPGEVLFSENFYQACRRCLNEGGILVTQNGTPFMQLEEVRTTAARTDGLFADWHFYQAAVPTYIGGAMTFAWGSTHEGLRRLPLETLRQRFRDSGIATRYYNADIHLGAFALPQYVLQAIGKQDND
References
External Links:
Resource Link
Genome ID: PA1687
Entrez Gene ID: 883061
NCBI Protein ID: 15596884
General Reference: PaperBLAST - Find papers about PA1687 and its homologs