Adenine phosphoribosyltransferase (PA1543)

Identification
Name: Adenine phosphoribosyltransferase
Synonyms:
  • APRT
Gene Name: apt
Enzyme Class:
Biological Properties
General Function: Involved in adenine phosphoribosyltransferase activity
Specific Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Guanine + Phosphoribosyl pyrophosphate → Guanosine monophosphate + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenine + Phosphoribosyl pyrophosphate ↔ Adenosine monophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine monophosphate + Pyrophosphate ↔ Adenine + Phosphoribosyl pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Guanosine monophosphate + Pyrophosphate ↔ Guanine + Phosphoribosyl pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
AICAR + Pyrophosphate ↔ 5-Amino-4-imidazolecarboxyamide + Phosphoribosyl pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Guanosine monophosphate + Pyrophosphate ↔ Guanine + Phosphoribosyl pyrophosphate
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SMPDB Reactions:
Thumb+Thumb → Pyrophosphate+Thumb
Adenine + Phosphoribosyl pyrophosphate → Pyrophosphate + Adenosine monophosphate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Guanine + Phosphoribosyl pyrophosphate → Guanosine monophosphate + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenine + Phosphoribosyl pyrophosphate ↔ Adenosine monophosphate + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Guanosine monophosphate + Pyrophosphate ↔ Guanine + Phosphoribosyl pyrophosphate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine monophosphate + Pyrophosphate → Adenine + Phosphoribosyl pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009465-Amino-4-imidazolecarboxyamideMetaboCard
PAMDB000010AdenineMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000407AICARMetaboCard
PAMDB000051GuanineMetaboCard
PAMDB000369Guanosine monophosphateMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenine phosphoribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
adenine salvage
cellular aromatic compound metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
purine base biosynthetic process
purine base metabolic process
purine base salvage
Gene Properties
Locus tag: PA1543
Strand: -
Entrez Gene ID: 879394
Accession: NP_250234.1
GI: 15596740
Sequence start: 1680437
Sequence End: 1680985
Sequence Length: 548
Gene Sequence: 
>PA1543
ATGATTTTCGACGAGTTCACCCTCAAGTCGCAGATCCGCGCCGTGCCGGACTTTCCCAAGCCCGGCGTGGTGTTCCGCGACATCACCCCGCTGTTCCAGTCGCCACGCGCGCTGCGCATGACCGTGGACAGCTTCGTCCAGCGCTACATCGAGGCCGATTTCAGCCACATCGGCGCCATGGATGCCCGCGGCTTCCTCATCGGCTCGGCGGTGGCCTATGCGCTGAACAAGCCGCTGGTCCTGTTCCGCAAGCAGGGCAAGCTACCCGCCGACGTACTCGCCGAGGGCTACCAGACCGAATACGGCGAGGCCTTCCTCGAAGTACATGCCGACAGCCTCTGCGAAGGCGACAGCGTACTGATCTTCGACGACCTCATCGCCACCGGCGGGACCCTGCTGGCGGCCGCGAGCCTGGTACGACGCCTCGGGGCCAGGGTCTTCGAGGCCGCGGCGATCATCGACCTGCCGGAACTCGGCGGCTCCACTCGCCTGCAGGACGCCGGCATCTCCACCTTCAGTCTCACCGCGTTCGCTCTCGACGAGCGTTGA
Protein Properties
Protein Residues: 182
Protein Molecular Weight: 19.8 kDa
Protein Theoretical pI: 4.58
Hydropathicity (GRAVY score): 0.248
Charge at pH 7 (predicted): -6.55
Protein Sequence: 
>PA1543
MIFDEFTLKSQIRAVPDFPKPGVVFRDITPLFQSPRALRMTVDSFVQRYIEADFSHIGAMDARGFLIGSAVAYALNKPLVLFRKQGKLPADVLAEGYQTEYGEAFLEVHADSLCEGDSVLIFDDLIATGGTLLAAASLVRRLGARVFEAAAIIDLPELGGSTRLQDAGISTFSLTAFALDER
References
External Links:
Resource Link
Genome ID: PA1543
Entrez Gene ID: 879394
NCBI Protein ID: 15596740
General Reference: PaperBLAST - Find papers about PA1543 and its homologs