Identification
Name: Phosphoribosylglycinamide formyltransferase
Synonyms:
  • 5'-phosphoribosylglycinamide transformylase
  • GAR transformylase
  • GART
Gene Name: purN
Enzyme Class:
Biological Properties
General Function: Involved in hydroxymethyl-, formyl- and related transferase activity
Specific Function: 10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+ThumbThumb+Thumb+Thumb
Thumb+ThumbThumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
SMPDB Reactions:
10-formyl-tetrahydrofolate mono-L-glutamate+ThumbThumb+Thumb+Thumb
PseudoCyc/BioCyc Reactions:
Thumb+ThumbThumb+Thumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0034315'-Phospho-ribosylglycinamideMetaboCard
PAMDB0003325'-Phosphoribosyl-N-formylglycineamideMetaboCard
PAMDB0015855,10-MethenyltetrahydrofolateMetaboCard
PAMDB000422GlycineamideribotideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB006363N1-(5-phospho-β-D-ribosyl)glycinamideMetaboCard
PAMDB000213N10-Formyl-THFMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB006378tetrahydropteroyl mono-L-glutamateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
glycine hydroxymethyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
methyltransferase activity
phosphoribosylglycinamide formyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
'de novo' IMP biosynthetic process
biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA0944
Strand: -
Entrez Gene ID: 878144
Accession: NP_249635.1
GI: 15596141
Sequence start: 1032095
Sequence End: 1032763
Sequence Length: 668
Gene Sequence:
>PA0944
ATGCCGAAACTCTGCAATGTCGTGGTGCTGATTTCCGGCTCCGGCAGCAACCTGCAGGCGCTGATCGACAGCCTCCGGGACGGCGCCACGCCGGCCCGGATCCGCGCGGTGATCTCCAACCGCGCGGACGCCTATGGCCTGGAACGCGCACGCCAGGCCGGCATCCAGACCGAGGTGCTCGATCACAAGGCCTATGCCGATCGCGAAAGCTTCGACGAGGCCCTGGCACAACGGATCGATGCCCATGAACCGCACCTGGTGATCCTTGCCGGGTTCATGCGCATCCTCAGCGCCGATTTCGTTCGCCATTACCAGGGGCGTCTGCTGAATATCCATCCCTCGTTGCTGCCGCGCCACAAAGGGCTGCATACCCATCAACGCGCCCTCGAAGCCGGCGACCGCGAGCACGGTTGCAGCGTGCACTTCGTGACGGAGGAACTCGATGGGGGGCCACTGGTCGTACAGGCAGTAATCCCGGTAGAGTCGCAAGATACGCCGGAACGCCTGGCCAGACGGGTTCACGAGGAAGAACACCGGATCTACCCGCTGGCCATGCGCTGGTTCGCCGAGGGCCGCTTGCGCCTGGGCGAACAGGGCGCCCTGCTGGATGGCCAGGCCCTGCCTGCCACCGGCCATCAGATTCGCACCAAGGAGATTCGCAATGCGTAA
Protein Properties
Protein Residues: 222
Protein Molecular Weight: 24.7 kDa
Protein Theoretical pI: 7.21
Hydropathicity (GRAVY score): -0.334
Charge at pH 7 (predicted): 1.06
Protein Sequence:
>PA0944
MPKLCNVVVLISGSGSNLQALIDSLRDGATPARIRAVISNRADAYGLERARQAGIQTEVLDHKAYADRESFDEALAQRIDAHEPHLVILAGFMRILSADFVRHYQGRLLNIHPSLLPRHKGLHTHQRALEAGDREHGCSVHFVTEELDGGPLVVQAVIPVESQDTPERLARRVHEEEHRIYPLAMRWFAEGRLRLGEQGALLDGQALPATGHQIRTKEIRNA
References
External Links:
Resource Link
Genome ID: PA0944
Entrez Gene ID: 878144
NCBI Protein ID: 15596141
General Reference: PaperBLAST - Find papers about PA0944 and its homologs