P. aeruginosa Metabolome Database Protein PA0944

Identification

Name:

Phosphoribosylglycinamide formyltransferase

Synonyms:

5'-phosphoribosylglycinamide transformylase
GAR transformylase
GART

Gene Name:

purN

Enzyme Class:

2.1.2.2

Biological Properties

General Function:

Involved in hydroxymethyl-, formyl- and related transferase activity

Specific Function:

10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide

Cellular Location:

Not Available

KEGG Pathways:

Metabolic pathways pae01100
One carbon pool by folate pae00670
Purine metabolism pae00230

KEGG Reactions:

SMPDB Reactions:

10-formyl-tetrahydrofolate mono-L-glutamate

→

10-formyl-tetrahydrofolate mono-L-glutamate + N1-(5-phospho-β-D-ribosyl)glycinamide → Hydrogen ion + tetrahydropteroyl mono-L-glutamate + 5'-Phosphoribosyl-N-formylglycineamide
ReactionCard

PseudoCyc/BioCyc Reactions:

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB003431	5'-Phospho-ribosylglycinamide	MetaboCard
PAMDB000332	5'-Phosphoribosyl-N-formylglycineamide	MetaboCard
PAMDB001585	5,10-Methenyltetrahydrofolate	MetaboCard
PAMDB000422	Glycineamideribotide	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB006363	N1-(5-phospho-β-D-ribosyl)glycinamide	MetaboCard
PAMDB000213	N10-Formyl-THF	MetaboCard
PAMDB000424	Tetrahydrofolic acid	MetaboCard
PAMDB006378	tetrahydropteroyl mono-L-glutamate	MetaboCard
PAMDB000142	Water	MetaboCard

GO Classification:

Function
catalytic activity
glycine hydroxymethyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
methyltransferase activity
phosphoribosylglycinamide formyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
'de novo' IMP biosynthetic process
biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process

Gene Properties

Locus tag:

PA0944

Strand:

Entrez Gene ID:

878144

Accession:

NP_249635.1

GI:

15596141

Sequence start:

1032095

Sequence End:

1032763

Sequence Length:

668

Gene Sequence:

>PA0944
ATGCCGAAACTCTGCAATGTCGTGGTGCTGATTTCCGGCTCCGGCAGCAACCTGCAGGCGCTGATCGACAGCCTCCGGGACGGCGCCACGCCGGCCCGGATCCGCGCGGTGATCTCCAACCGCGCGGACGCCTATGGCCTGGAACGCGCACGCCAGGCCGGCATCCAGACCGAGGTGCTCGATCACAAGGCCTATGCCGATCGCGAAAGCTTCGACGAGGCCCTGGCACAACGGATCGATGCCCATGAACCGCACCTGGTGATCCTTGCCGGGTTCATGCGCATCCTCAGCGCCGATTTCGTTCGCCATTACCAGGGGCGTCTGCTGAATATCCATCCCTCGTTGCTGCCGCGCCACAAAGGGCTGCATACCCATCAACGCGCCCTCGAAGCCGGCGACCGCGAGCACGGTTGCAGCGTGCACTTCGTGACGGAGGAACTCGATGGGGGGCCACTGGTCGTACAGGCAGTAATCCCGGTAGAGTCGCAAGATACGCCGGAACGCCTGGCCAGACGGGTTCACGAGGAAGAACACCGGATCTACCCGCTGGCCATGCGCTGGTTCGCCGAGGGCCGCTTGCGCCTGGGCGAACAGGGCGCCCTGCTGGATGGCCAGGCCCTGCCTGCCACCGGCCATCAGATTCGCACCAAGGAGATTCGCAATGCGTAA

Protein Properties

Protein Residues:

222

Protein Molecular Weight:

24.7 kDa

Protein Theoretical pI:

7.21

Hydropathicity (GRAVY score):

-0.334

Charge at pH 7 (predicted):

1.06

Protein Sequence:

>PA0944
MPKLCNVVVLISGSGSNLQALIDSLRDGATPARIRAVISNRADAYGLERARQAGIQTEVLDHKAYADRESFDEALAQRIDAHEPHLVILAGFMRILSADFVRHYQGRLLNIHPSLLPRHKGLHTHQRALEAGDREHGCSVHFVTEELDGGPLVVQAVIPVESQDTPERLARRVHEEEHRIYPLAMRWFAEGRLRLGEQGALLDGQALPATGHQIRTKEIRNA

References

External Links:

Resource	Link
Genome ID:	PA0944
Entrez Gene ID:	878144
NCBI Protein ID:	15596141

General Reference:

PaperBLAST - Find papers about PA0944 and its homologs

Phosphoribosylglycinamide formyltransferase (PA0944)