dTDP-4-dehydrorhamnose reductase (PA5162)

Identification
Name: dTDP-4-dehydrorhamnose reductase
Synonyms:
  • dTDP-4-keto-L-rhamnose reductase
  • dTDP-6-deoxy-L-lyxo-4-hexulose reductase
  • dTDP-6-deoxy-L-mannose dehydrogenase
  • dTDP-L-rhamnose synthase
Gene Name: rfbD
Enzyme Class:
Biological Properties
General Function: Involved in dTDP-4-dehydrorhamnose reductase activity
Specific Function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
dTDP-4-Dehydro-6-deoxy-L-mannose + Hydrogen ion + NADPH ↔ Deoxythymidine diphosphate-L-rhamnose + NADP
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Deoxythymidine diphosphate-L-rhamnose + NADP ↔ dTDP-4-Dehydro-6-deoxy-L-mannose + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
dTDP-4-dehydro-beta-L-rhamnose+Thumb+Thumb → Thumb+Thumb
dTDP-4-dehydro-beta-L-rhamnose + NADPH + Hydrogen ion → NADP + Deoxythymidine diphosphate-L-rhamnose
ReactionCard
dTDP-4-dehydro-beta-L-rhamnose+Thumb+Thumb → dTDP-6-deoxy-L-mannose+Thumb
dTDP-4-dehydro-beta-L-rhamnose + NADPH + Hydrogen ion → dTDP-6-deoxy-L-mannose + NADP
ReactionCard
dTDP-4-dehydro-beta-L-rhamnose+Thumb+Thumb → Thumb+Thumb
dTDP-4-dehydro-beta-L-rhamnose + NADH + Hydrogen ion → NADP + TDP-Rhamnose
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+dTDP-4-dehydro-6-deoxy-β-L-mannose
NADP + Deoxythymidine diphosphate-L-rhamnose ↔ Hydrogen ion + NADPH + dTDP-4-dehydro-6-deoxy-β-L-mannose
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000667Deoxythymidine diphosphate-L-rhamnoseMetaboCard
PAMDB001729dTDP-4-Dehydro-6-deoxy-L-mannoseMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB001344TDP-RhamnoseMetaboCard
GO Classification:
Function
binding
catalytic activity
dTDP-4-dehydrorhamnose reductase activity
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
carbohydrate metabolic process
cellular polysaccharide biosynthetic process
extracellular polysaccharide biosynthetic process
metabolic process
polysaccharide biosynthetic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA5162
Strand: +
Entrez Gene ID: 879983
Accession: NP_253849.1
GI: 15600355
Sequence start: 5811336
Sequence End: 5812244
Sequence Length: 908
Gene Sequence: 
>PA5162
ATGAACCGGATCCTTCTCCTCGGCGCCAACGGCCAGGTCGGCTGGGAGCTGCAGCGCGCCCTGGCGCCGCTGGGCGAACTGCTGGTCTGTGACCGTCGGCGCGCCGATCTCGCCGACCCCGAAGGCCTGGCGCGACTGGTTCGCGCCGAGCGGCCGCAGTTCATCGTCAACGCCGGTGCCTACACCGCGGTGGACAAGGCCGAGAGCGATGCCGACAACGCCCGCCTGATCAATGCCCGCGCCGTCGCGGTACTGGCCGAGGAGGCCGCGGCCTGCGGCGCCTGGCTGGTGCATTACTCCACCGACTACGTGTTCGACGGCGCGGGCAGCGTGCCTTTCGCCGAGGACGCGCCGACCGGCCCGCTGAGCGTCTACGGGCAGACCAAGCTGGAAGGCGAGCAGGCCATCCGCGCCAGCGGCTGCCGCCACCTGATCTTCCGCACCAGCTGGGTCTACGCCGCGCGCGGCGGAAACTTCGCCAAGACCATGCTGCGCCTGGCCGGGCAACGCGACGAACTCAAGGTCGTGGCCGACCAGTTCGGCGCGCCCACCAGCGCCGAGCTGATCGCCGACGTCACCGCCCAGGCCCTGCAGCGCCTGTGCTGGGATGTCGAGCTGGCAGCACGGGCCAGCGGCACCTACCACCTGGTCGCCAGCGGCGAGACGTCCTGGCACCTCTATGCGCGCTTCGTCATCGAACAGGCGCTGGAGCGGGGCTGGGAGTTGCAGGCGACGCCGCAGCGGGTCCTGCCGATCGCCACCGAGGACTACCCGGTGCCGGCGAAGCGTCCGGCCAATTCGCGCCTCGACAACCGCAAGCTGCAACAGGTCTTCGGCCTGGTACTGCCAGACTGGCGCTACCATGCCGGACGCATGATCCAGGAACTGAGCGAGCAGGGACCACTATGA
Protein Properties
Protein Residues: 302
Protein Molecular Weight: 33.1 kDa
Protein Theoretical pI: 6.05
Hydropathicity (GRAVY score): -0.15
Charge at pH 7 (predicted): -2.92
Protein Sequence: 
>PA5162
MNRILLLGANGQVGWELQRALAPLGELLVCDRRRADLADPEGLARLVRAERPQFIVNAGAYTAVDKAESDADNARLINARAVAVLAEEAAACGAWLVHYSTDYVFDGAGSVPFAEDAPTGPLSVYGQTKLEGEQAIRASGCRHLIFRTSWVYAARGGNFAKTMLRLAGQRDELKVVADQFGAPTSAELIADVTAQALQRLCWDVELAARASGTYHLVASGETSWHLYARFVIEQALERGWELQATPQRVLPIATEDYPVPAKRPANSRLDNRKLQQVFGLVLPDWRYHAGRMIQELSEQGPL
References
External Links:
Resource Link
Genome ID: PA5162
Entrez Gene ID: 879983
NCBI Protein ID: 15600355
General Reference: PaperBLAST - Find papers about PA5162 and its homologs