Identification
Name: Dihydrodipicolinate reductase
Synonyms:
  • DHPR
Gene Name: dapB
Enzyme Class:
Biological Properties
General Function: Involved in dihydrodipicolinate reductase activity
Specific Function: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
SMPDB Reactions:
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate+Thumb+NADPH+Thumb+ThumbThumb+Thumb+Thumb
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbThumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate+Thumb+NADPH+Thumb+ThumbThumb+Thumb+Thumb
Thumb
(S)-2,3-dihydrodipicolinate + NADPH + H+ = (S)-2,3,4,5-tetrahydrodipicolinate + NADP+
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB004261(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinateMetaboCard
PAMDB006304(S)-2,3,4,5-tetrahydrodipicolinateMetaboCard
PAMDB0005882,3-Dihydrodipicolinic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000840TetrahydrodipicolinateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
dihydrodipicolinate reductase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Process
aspartate family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
lysine biosynthetic process
lysine biosynthetic process via diaminopimelate
lysine metabolic process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA4759
Strand: -
Entrez Gene ID: 881759
Accession: NP_253447.1
GI: 15599953
Sequence start: 5345086
Sequence End: 5345892
Sequence Length: 806
Gene Sequence:
>PA4759
ATGCGACGTATAGCCGTAGTGGGCGCCGCCGGGCGCATGGGCAAGAACCTGATCGAGGCCGTTCAGCAGACCGGCGGTGCCGCCGGGCTGACGGCGGCGGTGGATCGTCCGGATAGCACCCTGGTGGGGGCGGACGCCGGCGAGCTGGCCGGTCTCGGCCGGATCGGCGTGCCGCTGTCCGGGGACCTGGGCAAGGTCTGCGAGGAGTTCGACGTCCTGATCGACTTCACCCATCCCTCCGTAACCCTGAAGAACATCGAGCAGTGCCGCAAGGCGCGCCGGGCGATGGTCATCGGCACCACCGGCTTCAGCGCCGACGAGAAGCTGCTGCTGGCCGAGGCGGCGAAGGATATCCCGATCGTCTTCGCTGCCAACTTCAGCGTCGGCGTGAACCTTTGCCTGAAGCTTCTGGATACCGCGGCACGGGTGTTGGGCGACGAAGTGGATATCGAGATCATCGAGGCCCATCACCGGCACAAGGTCGATGCACCGTCCGGCACCGCCTTGCGCATGGGCGAGGTGGTAGCCCAGGCGCTCGGCCGGGACCTCCAGGAAGTGGCGGTCTACGGACGCGAGGGGCAGACCGGCGCGCGGGCGCGGGAAACCATCGGCTTCGCCACCGTGCGCGCCGGCGACGTGGTGGGCGACCACACCGTGCTGTTCGCCGCCGAGGGCGAGCGCGTGGAGATCACCCACAAGGCTTCCAGCCGCATGACCTTCGCCCGTGGCGCGGTGCGTGCGGCGCTGTGGCTGGAGGGCAAGGAGAACGGCCTGTACGACATGCAGGATGTGCTCGGCCTACGCTGA
Protein Properties
Protein Residues: 268
Protein Molecular Weight: 28.3 kDa
Protein Theoretical pI: 5.98
Hydropathicity (GRAVY score): 0.071
Charge at pH 7 (predicted): -3.64
Protein Sequence:
>PA4759
MRRIAVVGAAGRMGKNLIEAVQQTGGAAGLTAAVDRPDSTLVGADAGELAGLGRIGVPLSGDLGKVCEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGTTGFSADEKLLLAEAAKDIPIVFAANFSVGVNLCLKLLDTAARVLGDEVDIEIIEAHHRHKVDAPSGTALRMGEVVAQALGRDLQEVAVYGREGQTGARARETIGFATVRAGDVVGDHTVLFAAEGERVEITHKASSRMTFARGAVRAALWLEGKENGLYDMQDVLGLR
References
External Links:
Resource Link
Genome ID: PA4759
Entrez Gene ID: 881759
NCBI Protein ID: 15599953
General Reference: PaperBLAST - Find papers about PA4759 and its homologs