Uracil phosphoribosyltransferase (PA4646)

Identification
Name: Uracil phosphoribosyltransferase
Synonyms:
  • UMP pyrophosphorylase
  • UPRTase
Gene Name: upp
Enzyme Class:
Biological Properties
General Function: Involved in nucleoside metabolic process
Specific Function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoribosyl pyrophosphate + Uracil ↔ Pyrophosphate + Uridine 5'-monophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Uridine 5'-monophosphate + Pyrophosphate ↔ Uracil + Phosphoribosyl pyrophosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoribosyl pyrophosphate + Uracil ↔ Pyrophosphate + Uridine 5'-monophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Uridine 5'-monophosphate + Pyrophosphate → Uracil + Phosphoribosyl pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000126UracilMetaboCard
PAMDB000118Uridine 5'-monophosphateMetaboCard
GO Classification:
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
uracil phosphoribosyltransferase activity
Process
cellular aromatic compound metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
pyrimidine base metabolic process
uracil metabolic process
uracil salvage
Gene Properties
Locus tag: PA4646
Strand: +
Entrez Gene ID: 881277
Accession: NP_253335.1
GI: 15599841
Sequence start: 5212833
Sequence End: 5213471
Sequence Length: 638
Gene Sequence: 
>PA4646
ATGCCCGTACATGAGATCCGCCACCCCCTCATCCGCCACAAACTGGGCCTGATGCGCCGTGCCGATATCAGCACCAAGAACTTCCGCGAACTGGCCCAGGAAGTCGGCGCCCTGCTGACCTACGAAGCGACCAAGGACCTGCCCCTGGAACAGTACGAAATCCCCGGATGGGCCGGCCCGGTGACGGTGGAGAAGATCTCCGGGAAGAAGATCACCGTGGTGCCGATCCTGCGCGCCGGCATCGGCATGCTCGACGGCGTGCTCAGCCTGATTCCCGGCGCCAAGGTCAGCGCGGTCGGCGTCGCCCGCAACGAAGAGACCCTGGAAGCACGCACCTACCTGGAAAAACTGGCGCCGGACATCGCCGAGCGACGCTCGCTGATCATCGACCCGATGCTCGCCACCGGTGGCTCGATGGTCGCCACCATCGACCTGCTGAAGAAGGCCGGCAGCAAGGAAATCCGCGCCATGGTGCTGGTCGCCGCCCCCGAGGGCATCGAGGCGGTACGCAAGGCCCACCCGGACGTGATCATCTATACCGCCTCGATCGACGAGAAGCTCGACGAGAACGGCTACATCATTCCGGGCCTGGGCGACGCCGGCGACAAGATCTTCGGTACCAAGCAGAAGGAAGCCTGA
Protein Properties
Protein Residues: 212
Protein Molecular Weight: 22.9 kDa
Protein Theoretical pI: 6.98
Hydropathicity (GRAVY score): -0.002
Charge at pH 7 (predicted): -0.04
Protein Sequence: 
>PA4646
MPVHEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLEQYEIPGWAGPVTVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLEARTYLEKLAPDIAERRSLIIDPMLATGGSMVATIDLLKKAGSKEIRAMVLVAAPEGIEAVRKAHPDVIIYTASIDEKLDENGYIIPGLGDAGDKIFGTKQKEA
References
External Links:
Resource Link
Genome ID: PA4646
Entrez Gene ID: 881277
NCBI Protein ID: 15599841
General Reference: PaperBLAST - Find papers about PA4646 and its homologs