3-deoxy-manno-octulosonate cytidylyltransferase (PA2979)

Identification
Name: 3-deoxy-manno-octulosonate cytidylyltransferase
Synonyms:
  • CMP-2-keto-3-deoxyoctulosonic acid synthase
  • CKS
  • CMP-KDO synthase
Gene Name: kdsB
Enzyme Class:
Biological Properties
General Function: Involved in lipopolysaccharide biosynthetic process
Specific Function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Cellular Location: Cytoplasm (Potential)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Cytidine triphosphate + 3-Deoxy-D-manno-octulosonate ↔ CMP-3-Deoxy-D-manno-octulosonate + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Cytidine triphosphate + 3-Deoxy-D-manno-octulosonate ↔ Pyrophosphate + CMP-3-Deoxy-D-manno-octulosonate
ReactionCard
SMPDB Reactions:
3-deoxy-D-manno-octulosonate+Thumb+Thumb → Pyrophosphate+Thumb
3-deoxy-D-manno-octulosonate + Cytidine triphosphate + 3-Deoxy-D-manno-octulosonate → Pyrophosphate + CMP-3-Deoxy-D-manno-octulosonate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Cytidine triphosphate + 3-Deoxy-D-manno-octulosonate ↔ CMP-3-Deoxy-D-manno-octulosonate + Pyrophosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb
3-Deoxy-D-manno-octulosonate + Cytidine triphosphate → CMP-3-Deoxy-D-manno-octulosonate + Pyrophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Cytidine triphosphate + 3-Deoxy-D-manno-octulosonate → Pyrophosphate + CMP-3-Deoxy-D-manno-octulosonate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009183-Deoxy-D-manno-octulosonateMetaboCard
PAMDB000981CMP-3-Deoxy-D-manno-octulosonateMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
3-deoxy-manno-octulosonate cytidylyltransferase activity
catalytic activity
cytidylyltransferase activity
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
primary metabolic process
Gene Properties
Locus tag: PA2979
Strand: -
Entrez Gene ID: 880169
Accession: NP_251669.1
GI: 15598175
Sequence start: 3337692
Sequence End: 3338456
Sequence Length: 764
Gene Sequence: 
>PA2979
ATGACCCAGGCGTTCACTGTCGTCATTCCCGCCCGCTACGCCTCCACTCGCCTGCCCGGCAAGCCATTGCAGGATATCGCCGGCCAGCCAATGATCCAGCGCGTCTGGAACCAGGCCCGCAAGAGCGCCGCCAGCCGCGTGGTCGTCGCCACCGACGACGAACGCATCCTGGCGGCGTGCCAGGGGTTCGGCGCCGAGGCGCTGCTGACGCGTGCCGAGCACAACTCCGGCACCGATCGCCTGGAGGAAGTCGCTTCCCGGCTCGGCCTGGCCAGCGATGCCATCGTGGTCAACGTCCAGGGCGACGAACCGCTGATCCCCCCGGCGCTCATCGACCAGGTGGCGGCCAACCTGGCGGCGCACCCGGAAGCTGCCATCGCTACCCTGGCCGAGCCGATCCATGAGGTCTCCGCGCTGTTCAATCCGAACGTGGTCAAGGTCGCCACCGACATCGACGGCCTGGCCCTGACTTTCAGTCGTGCGCCCTTGCCCTGGGCTCGCGACGCCTTCGCCCGCGATCGCGACAGCCTGCCGGAGGGCGTGCCCTATCGTCGCCACATCGGCATCTACGCCTATCGCGTGGGTTTCCTTGCCGATTTCGTCGCCTGGGGACCGTGCTGGCTGGAGAACGCCGAAAGCCTTGAGCAATTGCGCGCGCTCTGGCACGGGGTGCGAATCCATGTGGCCGATGCCCGCGAAAACATGCTTCCGGGCGTGGATACGCCGGAAGACCTCGAACGCGTTCGCCGCGTGTTGGGGGGCTGA
Protein Properties
Protein Residues: 254
Protein Molecular Weight: 27.6 kDa
Protein Theoretical pI: 5.35
Hydropathicity (GRAVY score): -0.036
Charge at pH 7 (predicted): -5.61
Protein Sequence: 
>PA2979
MTQAFTVVIPARYASTRLPGKPLQDIAGQPMIQRVWNQARKSAASRVVVATDDERILAACQGFGAEALLTRAEHNSGTDRLEEVASRLGLASDAIVVNVQGDEPLIPPALIDQVAANLAAHPEAAIATLAEPIHEVSALFNPNVVKVATDIDGLALTFSRAPLPWARDAFARDRDSLPEGVPYRRHIGIYAYRVGFLADFVAWGPCWLENAESLEQLRALWHGVRIHVADARENMLPGVDTPEDLERVRRVLGG
References
External Links:
Resource Link
Genome ID: PA2979
Entrez Gene ID: 880169
NCBI Protein ID: 15598175
General Reference: PaperBLAST - Find papers about PA2979 and its homologs