Periplasmic trehalase (PA2416)

Identification
Name: Periplasmic trehalase
Synonyms:
  • Alpha,alpha-trehalase
  • Alpha,alpha-trehalose glucohydrolase
Gene Name: treA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Cellular Location: Periplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ 2 Thumb
Trehalose + Water ↔ 2 D-Glucose
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Trehalose + Water ↔ b-D-Glucose + alpha-D-Glucose
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Beta-D-Glucose+Thumb+Thumb
α,α-trehalose + Water → Beta-D-Glucose + alpha-D-Glucose + b-D-Glucose
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Trehalose + Water → b-D-Glucose + D-Glucose
ReactionCard
Complex Reactions:
Thumb+Thumb → 2 Thumb
Water + Trehalose → 2 D-Glucose
ReactionCard
Thumb+Thumb → Thumb+Thumb
Trehalose + Water → b-D-Glucose + alpha-D-Glucose
ReactionCard
Thumb+Thumb → Thumb+Thumb
Trehalose + Water → b-D-Glucose + alpha-D-Glucose
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000492alpha-D-GlucoseMetaboCard
PAMDB000145b-D-GlucoseMetaboCard
PAMDB000045D-GlucoseMetaboCard
PAMDB000214TrehaloseMetaboCard
PAMDB000142WaterMetaboCard
PAMDB006373α,α-trehaloseMetaboCard
GO Classification:
Function
alpha,alpha-trehalase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing O-glycosyl compounds
trehalase activity
Process
carbohydrate metabolic process
disaccharide metabolic process
metabolic process
oligosaccharide metabolic process
primary metabolic process
trehalose metabolic process
Gene Properties
Locus tag: PA2416
Strand: +
Entrez Gene ID: 882861
Accession: NP_251106.1
GI: 15597612
Sequence start: 2698526
Sequence End: 2700163
Sequence Length: 1637
Gene Sequence: 
>PA2416
ATGCCTGATCGAACCGCTCTACCCCGCGCCATGCTCGCGGCCTGGGTCCTGCTCCTGCTGGCGGCCTGCAGCCAGGGCCCGGCGCCTACCCCGCCCGCGTCCTGGGGTTGGCAGGACGCCAGCGGCGAACGCGCGATCGCCCCCGACGAAGCCTATCCCGAGCTGTTCCAGGCGGTGCAGGAAAACCGGCTGTTCAGCGACCAGAAGCACTTCGTCGATGCGCTCCCGCTGCGCGAGCCTGCACGGATCCGCGCCGACTACCTGCGCGAGAGGGAGCGGCCCGGCTTCGACCTGCGCGCCTTCGTCGGCCGCAACTTCGAGGAGTCCGGCAGCGTCGAGACCGCCCCGCCGGAAGCGGGTGCCGATCTCGCCAGCCACATCAGCGACCTGTGGCCGGCGTTGACCCGCCACTACGAGCAGGTGCCGGCCCACAGCAGCCTGCTGCCGCTGCCGAAACCCTACGTGGTCCCCGGCGGACGCTTCCGCGAGGTGTACTACTGGGACTCCTACTTCACCATGCTCGGCCTTGCGGAGAGCGGGCAGCACCAGCGGGTGCGCGACATGCTCGACAACTTCGCCTACCTGATCGATACCTACGGGCACATTCCCAACGGTAACCGCAGCTACTACCTGAGCCGTTCGCAGCCGCCGTTCTTCGCCTACATGGTGGATCTCCAGGCAAGACGCGAAGGCGACGCCGCCTACCGGCGCTACCTGCCGCAGCTACAGAAGGAATACGCCTACTGGATGGAAGGCTCCGCCGGGCTGCGCCCCAACGAGGCGCGCCTGCACGTGGTGAAACTGGCCGACGGAAGCCTGCTGAACCGCTACTGGGACAACCGTGACACACCGCGCCAGGAGTCCTTCCTGGAGGACCGGGCGACCGCCGCGCGCGCCCCGCAGCGCCCCGCGGGCGAGGTCTATCGCGACCTGCGGGCCGGCGCGGAAAGCGGCTGGGACTTCTCCTCCCGCTGGCTGGACGACGGCCGCGAACTGGCCAGCATCCGCACCACCGCCATCGTCCCGGTGGACCTCAACGCCCTGCTCTACCATCTCGAACGAATCATCGCCAAGGCCTGCGCCAGCAGCGCGCTGAAGGCCTGCGAGCAAGGCTACGGCGCCCGCGCGGAGAAGCGACGACAGGCCATCGAAGACCACCTCTGGCACCCGGCGGGCTACTACGCCGACTACGACTGGCAACGCCGGCGGCCCATCGAGCGGATCAACGCCGCCAGCCTCTTCCCGCTATTCACCGGGCTGGCCTCCGCCGAACGCGCCGGTCGTACCGCCGACAGCGTCGCCGCCCAACTGCTGCGCCCGGGCGGACTGGCCACCACCACCCGTGCCAGCGGCCAGCAATGGGACGAGCCGAACGGCTGGGCACCCTTGCAGTGGGTCGCCGTACAGGGCCTGCGCGCCTACGGCCGGGACGCCCTGGCGGAAGACATCGGCCGGCGATTCCTCGCCCAGGTGCAGCAGGTCTACGACCGCGAAGGAAAACTGGTGGAGAAATACGACATCAGCGGCAACCAGGGCGGCGGCGGCGGTGGCGAGTACCCGTTGCAGGACGGCTTCGGCTGGTCCAACGGCGTGACCCTGCAACTGCTCCGACTCTACGGCCCGGGCGCCGGTCGCTGA
Protein Properties
Protein Residues: 545
Protein Molecular Weight: 61.2 kDa
Protein Theoretical pI: 6.69
Hydropathicity (GRAVY score): -0.53
Charge at pH 7 (predicted): -1.67
Protein Sequence: 
>PA2416
MPDRTALPRAMLAAWVLLLLAACSQGPAPTPPASWGWQDASGERAIAPDEAYPELFQAVQENRLFSDQKHFVDALPLREPARIRADYLRERERPGFDLRAFVGRNFEESGSVETAPPEAGADLASHISDLWPALTRHYEQVPAHSSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGQHQRVRDMLDNFAYLIDTYGHIPNGNRSYYLSRSQPPFFAYMVDLQARREGDAAYRRYLPQLQKEYAYWMEGSAGLRPNEARLHVVKLADGSLLNRYWDNRDTPRQESFLEDRATAARAPQRPAGEVYRDLRAGAESGWDFSSRWLDDGRELASIRTTAIVPVDLNALLYHLERIIAKACASSALKACEQGYGARAEKRRQAIEDHLWHPAGYYADYDWQRRRPIERINAASLFPLFTGLASAERAGRTADSVAAQLLRPGGLATTTRASGQQWDEPNGWAPLQWVAVQGLRAYGRDALAEDIGRRFLAQVQQVYDREGKLVEKYDISGNQGGGGGGEYPLQDGFGWSNGVTLQLLRLYGPGAGR
References
External Links:
Resource Link
Genome ID: PA2416
Entrez Gene ID: 882861
NCBI Protein ID: 15597612
General Reference: PaperBLAST - Find papers about PA2416 and its homologs