Pyrroline-5-carboxylate reductase (PA0393)

Identification
Name: Pyrroline-5-carboxylate reductase
Synonyms:
  • P5C reductase
  • P5CR
Gene Name: proC
Enzyme Class:
Biological Properties
General Function: Involved in oxidation-reduction process
Specific Function: L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+2 Thumb+Thumb → Thumb+Thumb
L-D-1-Pyrroline-5-carboxylic acid + 2 Hydrogen ion + NADPH → NADP + L-Proline
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Proline + NAD ↔ L-D-1-Pyrroline-5-carboxylic acid + NADH + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Proline + NADP ↔ L-D-1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydroxyproline + NAD ↔ Pyrroline hydroxycarboxylic acid + NADH + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydroxyproline + NADP ↔ Pyrroline hydroxycarboxylic acid + NADPH + Hydrogen ion
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Proline + NAD + NADP ↔ (S)-1-pyrroline-5-carboxylate + NADH + NADPH + Hydrogen ion
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SMPDB Reactions:
1-Pyrroline-5-carboxylic acid+Thumb+NADPH+Thumb+Thumb → Thumb+L-Proline+Thumb
1-Pyrroline-5-carboxylic acid + Hydrogen ion + NADPH + L-D-1-Pyrroline-5-carboxylic acid + NADPH → NADP + L-Proline + L-Proline
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PseudoCyc/BioCyc Reactions:
Thumb+2 Thumb+Thumb → Thumb+Thumb
L-D-1-Pyrroline-5-carboxylic acid + 2 Hydrogen ion + NADPH → NADP + L-Proline
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Proline + NAD ↔ L-D-1-Pyrroline-5-carboxylic acid + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Proline + NADP ↔ L-D-1-Pyrroline-5-carboxylic acid + NADPH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydroxyproline + NAD ↔ Pyrroline hydroxycarboxylic acid + NADH + Hydrogen ion
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Hydroxyproline + NADP ↔ Pyrroline hydroxycarboxylic acid + NADPH + Hydrogen ion
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Thumb+NAD(P)(+) → Thumb+NAD(P)H
L-Proline + NAD(P)(+) → L-D-1-Pyrroline-5-carboxylic acid + NAD(P)H
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Proline + NAD + NADP ↔ (S)-1-pyrroline-5-carboxylate + NADH + NADPH + Hydrogen ion
ReactionCard
1-Pyrroline-5-carboxylic acid+Thumb+NADPH+Thumb+Thumb → Thumb+L-Proline+Thumb
1-Pyrroline-5-carboxylic acid + Hydrogen ion + NADPH + L-D-1-Pyrroline-5-carboxylic acid + NADPH → NADP + L-Proline + L-Proline
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Thumb
L-proline + NAD(P)+ ← (S)-1-pyrroline-5-carboxylate + NAD(P)H + 2 H+
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Complex Reactions:
Thumb+NAD(P)(+) → Thumb+NAD(P)H
L-Proline + NAD(P)(+) → L-D-1-Pyrroline-5-carboxylic acid + NAD(P)H
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB003496(S)-1-pyrroline-5-carboxylateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000179HydroxyprolineMetaboCard
PAMDB000329L-D-1-Pyrroline-5-carboxylic acidMetaboCard
PAMDB000064L-ProlineMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000359Pyrroline hydroxycarboxylic acidMetaboCard
GO Classification:
Function
binding
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH group of donors
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
pyrroline-5-carboxylate reductase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
oxidation reduction
proline biosynthetic process
proline metabolic process
Gene Properties
Locus tag: PA0393
Strand: -
Entrez Gene ID: 878413
Accession: NP_249084.1
GI: 15595590
Sequence start: 434830
Sequence End: 435651
Sequence Length: 821
Gene Sequence: 
>PA0393
ATGAGCACACCCCGCATAGCGTTCATCGGCGCCGGCAACATGGCCGCCAGCCTGATCGGCGGCCTGCGCGCCCAAGGCGTGCCGGCGGCGCAGATCCGCGCCAGCGACCCGGGCGCCGAGCAACGCGCGAAGATCGCCGGCGAGTTCGCCATCGACGTGGTCGAGTCCAACGCCGAGGCCGTGGCCGACGCCGACGTCGTGGTCCTGTCGGTCAAGCCGCAGGCCATGAAAGCCGTGTGCCAGGCCTTGGCGCCGGCGCTGAAGCCGGAGCAACTGATCGTCTCCATCGCCGCCGGCATCCCCTGCGCCAGCCTCGAAGCCTGGCTCGGCCAGCCGCGCCCGGTGGTCCGCTGCATGCCCAACACCCCGGCGCTGCTGCGCCAGGGCGCCAGCGGGCTGTACGCCAACGCGCAGGTCAGCGCCGCGCAATGCGAGCAGGCCGGGCAGTTGCTGTCCGCGGTGGGCATCGCCCTGTGGCTGGACGACGAAGCGCAGATCGACGCGGTGACCGCAGTGTCGGGCAGCGGCCCGGCGTATTTCTTCCTGCTGATGCAGGCCATGACCGACGCCGGCGAGAAGCTCGGCCTGTCCCGCGAGACAGCCTCGCGCCTGACCCTGCAGACCGCCCTCGGTGCGGCGCAGATGGCGCTGTCCAGCGAGGTCGAGCCGGCCGAACTGCGGCGCCGGGTGACTTCGCCCAACGGCACCACCGAGGCGGCGATCAAATCCTTCCAGGCCAACGGCTTCGAAGCACTGGTGGAGCAGGCCCTGAACGCCGCCAGCCAGCGCTCCGCCGAGCTGGCCGAACAGCTTGGCCAATAA
Protein Properties
Protein Residues: 273
Protein Molecular Weight: 28.1 kDa
Protein Theoretical pI: 4.49
Hydropathicity (GRAVY score): 0.184
Charge at pH 7 (predicted): -7.12
Protein Sequence: 
>PA0393
MSTPRIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ
References
External Links:
Resource Link
Genome ID: PA0393
Entrez Gene ID: 878413
NCBI Protein ID: 15595590
General Reference: PaperBLAST - Find papers about PA0393 and its homologs