Reaction 21350

Reaction Details
Reaction: Thumb
L-proline + NAD(P)+ ← (S)-1-pyrroline-5-carboxylate + NAD(P)H + 2 H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:PYRROLINECARBREDUCT-RXN
References:
  • Aams E, Goldstone A (1960). "Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta 1-pyrroline-3-hydroxy-5-carboxylate." J Biol Chem 235;3499-503. PMID: 13681369
  • Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline." J Biol Chem 229(2);789-800. PMID: 13502341
  • Smith ME, Greenberg DM (1956). "Characterization of an enzyme reducing pyrroline-5-carboxylate to proline." Nature 177(4520);1130. PMID: 13334497
  • Yura T, Vogel HJ (1959). "Pyrroline-5-carboxylate reductase of Neurospora crassa; partial purification and some properties." J Biol Chem 234(2);335-8. PMID: 13630905