Identification |
Name: |
Thiazole synthase |
Synonyms: |
Not Available |
Gene Name: |
thiG |
Enzyme Class: |
|
Biological Properties |
General Function: |
Involved in catalytic activity |
Specific Function: |
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S |
Cellular Location: |
Cytoplasm |
KEGG Pathways: |
|
KEGG Reactions: |
|
C15815 | + | ![Thumb](/molecules/PAMDB000060thumb.png) | + | Iminoglycine | ↔ | ![Thumb](/molecules/PAMDB000942thumb.png) |
| | | |
|
SMPDB Reactions: |
|
![Thumb](/molecules/PAMDB000301thumb.png) | + | ![Thumb](/molecules/PAMDB001730thumb.png) | + | a thiocarboxy-[ThiS-Protein] | → | ![Thumb](/molecules/PAMDB003443thumb.png) | + | a ThiS sulfur-carrier protein | + | 2 ![Thumb](/molecules/PAMDB000142thumb.png) |
| |
|
PseudoCyc/BioCyc Reactions: |
| | |
C15815 | + | ![Thumb](/molecules/PAMDB000060thumb.png) | + | Iminoglycine | ↔ | ![Thumb](/molecules/PAMDB000942thumb.png) |
| | |
![Thumb](/molecules/PAMDB000301thumb.png) | + | ![Thumb](/molecules/PAMDB003545thumb.png) | + | thiocarboxy-adenylate-[sulfur-carrier protein ThiS] | → | ![Thumb](/molecules/PAMDB003443thumb.png) | + | [sulfur-carrier protein ThiS] | + | 2 ![Thumb](/molecules/PAMDB000142thumb.png) |
| | | |
|
Complex Reactions: |
| | |
![Thumb](/molecules/PAMDB000301thumb.png) | + | ![Thumb](/molecules/PAMDB003545thumb.png) | + | thiocarboxy-adenylate-[sulfur-carrier protein ThiS] | → | ![Thumb](/molecules/PAMDB003443thumb.png) | + | [sulfur-carrier protein ThiS] | + | 2 ![Thumb](/molecules/PAMDB000142thumb.png) |
| |
|
Transports: |
Not Available |
Metabolites: |
|
GO Classification: |
Function |
---|
catalytic activity | Process |
---|
cellular aromatic compound metabolic process | cellular metabolic process | metabolic process | thiamin and derivative metabolic process | thiamin biosynthetic process | thiamin metabolic process |
|
Gene Properties |
Locus tag: |
PA0381 |
Strand: |
+ |
Entrez Gene ID: |
879802 |
Accession: |
NP_249072.1 |
GI: |
15595578 |
Sequence start: |
423719 |
Sequence End: |
424516 |
Sequence Length: |
797 |
Gene Sequence: |
>PA0381
ATGAGCCAAGCATCCAGTACCGATACCCCCTTCGTCATCGCCGGCCGTACCTATGGCTCGCGCCTGCTGGTGGGGACCGGCAAGTACAAGGACCTCGACGAGACCCGCCGGGCCATCGAGGCCTCCGGAGCGGAGATCGTCACGGTGGCGGTGCGGCGCACCAACATCGGGCAGAATCCCGACGAGCCGAACCTGCTGGATGTGATCCCGCCGGATCGCTACACCATCCTGCCGAACACCGCCGGCTGCTATGACGCGGTCGAGGCCGTGCGCACCTGCCGCCTGGCCCGCGAGCTGCTGGACGGGCACAACCTGGTCAAGCTGGAAGTCCTCGCCGACCAGAAGACCCTGTTCCCCAACGTCGTCGAGACCCTCAAGGCCGCCGAGCAACTGGTGAAGGACGGCTTCGACGTGATGGTGTACACCAGCGACGACCCGATCATCGCCCGCCAACTGGCCGAGATCGGCTGCATCGCGGTGATGCCGCTGGCCGGCCTGATCGGCTCCGGCCTGGGCATCTGCAACCCCTACAACCTGCGCATCATCCTCGAGGAAGCCAAGGTCCCGGTGCTGGTAGACGCCGGCGTGGGCACCGCTTCCGATGCAGCGATCGCCATGGAGCTGGGTTGCGAGGCGGTGCTGATGAACACCGCCATCGCCCATGCCAAGGACCCGGTGATGATGGCCGAGGCCATGAAGCACGCGATCGTCGCCGGTCGTCTCGCCTACCTGGCCGGACGCATGCCGCGCAAGCTGTATGCCAGCGCCTCGTCGCCGCTGGACGGCCTGATCGACTGA |
Protein Properties |
Protein Residues: |
265 |
Protein Molecular Weight: |
28.2 kDa |
Protein Theoretical pI: |
4.75 |
Hydropathicity (GRAVY score): |
0.182 |
Charge at pH 7 (predicted): |
-7.43 |
Protein Sequence: |
>PA0381
MSQASSTDTPFVIAGRTYGSRLLVGTGKYKDLDETRRAIEASGAEIVTVAVRRTNIGQNPDEPNLLDVIPPDRYTILPNTAGCYDAVEAVRTCRLARELLDGHNLVKLEVLADQKTLFPNVVETLKAAEQLVKDGFDVMVYTSDDPIIARQLAEIGCIAVMPLAGLIGSGLGICNPYNLRIILEEAKVPVLVDAGVGTASDAAIAMELGCEAVLMNTAIAHAKDPVMMAEAMKHAIVAGRLAYLAGRMPRKLYASASSPLDGLID |
References |
External Links: |
|
General Reference: |
PaperBLAST - Find papers about PA0381 and its homologs
|