Glyoxylic acid (PAMDB000043)

General function:

Involved in isocitrate lyase activity

Specific function:

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway

Gene Name:

aceA

Locus Tag:

PA2634

Molecular weight:

58.9 kDa

Reactions

General function:

Involved in tartronate-semialdehyde synthase activity

Specific function:

Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)

Gene Name:

gcl

Locus Tag:

PA1502

Molecular weight:

64.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

glcD

Locus Tag:

PA5355

Molecular weight:

53.7 kDa

General function:

Involved in catalytic activity

Specific function:

Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate

Gene Name:

glcB

Locus Tag:

PA0482

Molecular weight:

78.7 kDa

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D- gluconate (5KDG), 2-keto-D-gluconate (2KDG) to D-gluconate, and 2- keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D-fructose and L- sorbose. Activity with NAD is very low

Gene Name:

ghrB

Locus Tag:

PA2263

Molecular weight:

35.6 kDa

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Specific function unknown

Gene Name:

glcF

Locus Tag:

PA5353

Molecular weight:

44.7 kDa

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate

Gene Name:

allA

Locus Tag:

PA1514

Molecular weight:

19 kDa

Reactions

General function:

Involved in alkanesulfonate monooxygenase activity

Specific function:

Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers

Gene Name:

ssuD

Locus Tag:

PA3444

Molecular weight:

41.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

glcE

Locus Tag:

PA5354

Molecular weight:

38.2 kDa