| Identification |
| Name: |
DNA polymerase I |
| Synonyms: |
|
| Gene Name: |
polA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleic acid binding |
| Specific Function: |
In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template |
| Cellular Location: |
Cytoplasmic |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + | DNA | ↔ |  | + | DNA |
| | |
 | + | DNA | ↔ | | + | DNA |
| | |
 | + | DNA | ↔ | | + | DNA |
| | |
 | + | DNA | ↔ | | + | DNA |
| | |
Deoxynucleoside triphosphate | + | DNA | ↔ | |
| |
|
| SMPDB Reactions: |
Not Available |
| PseudoCyc/BioCyc Reactions: |
|
DNAn | ? | a nucleoside monophosphate |
| | |
? | a 5'-phosphomononucleotide |
| |
|
| Complex Reactions: |
|
Deoxynucleoside triphosphate | + | DNA(n) | → | | + | DNA(n+1) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | intracellular | | Function |
|---|
| 3'-5' exonuclease activity | | 5'-3' exonuclease activity | | binding | | catalytic activity | | DNA binding | | DNA polymerase activity | | DNA-directed DNA polymerase activity | | exonuclease activity | | hydrolase activity | | hydrolase activity, acting on ester bonds | | nuclease activity | | nucleic acid binding | | nucleotidyltransferase activity | | transferase activity | | transferase activity, transferring phosphorus-containing groups | | Process |
|---|
| cellular macromolecule metabolic process | | cellular nitrogen compound metabolic process | | DNA metabolic process | | DNA repair | | DNA replication | | macromolecule metabolic process | | metabolic process | | nitrogen compound metabolic process | | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
| Gene Properties |
| Locus tag: |
PA5493 |
| Strand: |
- |
| Entrez Gene ID: |
877794 |
| Accession: |
NP_254180.1 |
| GI: |
15600686 |
| Sequence start: |
6183784 |
| Sequence End: |
6186525 |
| Sequence Length: |
2741 |
| Gene Sequence: |
>PA5493
ATGAGCCAAGCGCCCCTCGTCCTGGTGGACGGTTCCTCGTACCTGTACCGCGCCTTCCATGCCCTGCCGCCGCTGACCACCTCGACCGGCAAGCCCACCGGTGCGGTGAAGGGCGTGCTGAACATGCTCCTGAGCCTGCGCAAGCAGTACCCGGACAGCCCGTTCGCGGTGGTCTTCGACGCCAAGGGCCCGACCTTCCGCGACGAGCTGTTCGCCGAGTACAAGGCCAACCGGCCGTCGATGCCCGACGACCTGCGGGTCCAGGTCGAGCCGCTGCATGCCAGCGTCCGCGCCCTCGGCCTGCCGCTGCTGTGCGTGGAGGGGGTCGAGGCCGACGACGTGATCGGCACCCTGGCGCGCAGCAGCGCCGCGGCTGACCGCCCGGTGGTGATTTCCACCGGCGACAAGGACATGGCGCAACTGGTCGACGGGCACATTACGCTGGTCAACACCATGACCGGTAGCCGCCTCGACGTGGATGGCGTGAAAGAGAAATTCGGCGTCGGTCCTGAGCTGATCATCGATTTCCTCGCCCTGATGGGCGACAAGGTCGACAACATCCCCGGCGTTCCGGGTGTCGGCGAGAAAACCGCGCTGGGCCTGCTGACCGGTGTCGGTGGCGGCCTGGAGGTGCTCTACGCCAGCCTGGACAAGGTGCCCGAGCTACCGATCCGCGGCGCCAAGGGCTTGCCGGCGAAGCTCGAGGAAAATCGCGAGCAGGCGTTCCTGTCCTATCAACTGGCGACCATCAAGACCGACGTCGAACTGGACGTGGAGATCGACAAGCTGTATCCCGGCGAGCCGCAGCGCGAAGCGCTGATCGCCCTGTACCGCGAGCTGGAGTTCAAGAACTGGCTGGACGACCTCCTGCGCGAGGCCAAGGAGGCCGGCGAGAACGGCGAGGCGGAAACGCCTATCCAGGCCGAGGTCGACTACGACGTGGTGCTCGACCAGGCCGGATTCGACGCCTGGCTGAAGAAGCTGGAGGAGGCCGAGCTGATCGCCTTCGATACCGAGACCACCAGCATCGACGCCCAGCAGGCGCAGGTGGTGGGGGTGTCCTTCGCCGTGAAGGAGGGCGAGGCCGCCTACGTGCCGCTGGCCCACAGCTACATGGGCGTTCCGGAGCAACTGGATCGTGACGCGGTGCTGCGTGCGTTGAAACCGCTGCTGGAGGATCCGAAGAAGCTCAAGGTCGGCCAGCATGCCAAGTACGACATCAATGTCCTGGCCAATGCCAGCACCCCCATCGCGCTGCGGGGCGTAGCCTACGACACCATGCTCGAGTCCTATGTGCTGGACTCCACCGCCACTCGCCACGACATGGACAGCCTGGCCCTGAAGTACCTCGGCCACAGCACCATCCGTTTCGAGGACATCGCCGGCAAGGGCGCCAAGCAACTGACCTTCGACCAGATCGCCATCGAACAGGCCGGGCCCTATGCGGCGGAGGACGCCGACGTGACCCTGCGCCTGCACCAGGCCCTGTGGCAGAAGCTGGAGGCGATCCCGTCCCTGGCCAGGGTCCTGACCGACATCGAGATGCCGCTGGTACCGGTGCTGGCGCGGATCGAGCGCAACGGCGCGCTGGTCGACGCCAACCTGCTGGGCATCCAGAGCCGCGAACTGGGCGAGAAGATGGTCGCCCTGGAGCGCCAGGCATACGACCTGGCAGGGCAGGAATTCAACCTCGGCTCGCCCAAGCAGCTCGGCGCGATCCTCTACGACAAGCTCGGCCTGCCGGTTCTGAGCAAGACCGCGACCGGCCAGCCGTCCACCGCCGAGGCAGTGCTCGCCGAACTGGCCGAGCAGGACTTCGAGCTGCCCAAGGTGATCATGCAGTACCGCTCCATGAGCAAGCTCAAGAGCACCTACACCGACCGCCTGCCCGAGCAGATCAACCCGCGTACCGGACGCATCCATACCTCATACCACCAGGCGGTGGCGGCTACCGGGCGGCTGTCGTCGAGCGACCCGAACCTGCAGAACATCCCGATCCGTACCGCGGAGGGCCGGCGCATCCGCCAGGCGTTCGTCGCGCCGCAGGGCTACAAGCTATTGGCCGCGGACTACTCGCAGATCGAGCTGCGGATCATGGCCCACCTGGCCAAGGACGATGGCCTGCTGGATGCCTTCCGCCACGACCTGGACGTACACCGCGCCACCGCGGCGGAAGTCTTCGGCGTGCCGCTGGAAGACGTCAGCGGCGACCAGCGACGCAGCGCCAAGGCGATCAACTTCGGATTGATCTACGGCATGAGCGCCTTCGGCCTGGCCAAGCAGATCGGCGTCGAGCGCAAGGAGGCCCAGGCCTACATCGACCGTTACTTCGCCCGCTACCCCGGCGTCCTGGCGTACATGGAGCGGACCCGCGCCCAGGCCGCGGAGCAGGGCTTCGTCGAAACCCTGTTCGGCCGTCGCCTGTACCTGCCGGAGATCCATTCGAAGAACGGTGCCATGCGCAAGGCCGCCGAGCGCACCGCGATCAACGCGCCGATGCAGGGCACCGCGGCGGACATCATGAAGCGCGCCATGGTCGCTGTGGATAACTGGCTGCAGGAAAGCGGCCTCGATGCCCGGGTGATCCTCCAGGTGCACGACGAACTGGTGCTGGAAGTGCGCGAGGACCTGGTCGAGCAGGTGTGCGAGGGAATCCGCCCGCTGATGAGCGGAGCGGCGACCCTGGACGTACCGCTGGTGGTCGAGGCGGGTGTCGGTTCGAACTGGGACGAAGCCCACTGA |
| Protein Properties |
| Protein Residues: |
913 |
| Protein Molecular Weight: |
99.8 kDa |
| Protein Theoretical pI: |
4.75 |
| Hydropathicity (GRAVY score): |
-0.135 |
| Charge at pH 7 (predicted): |
-32.14 |
| Protein Sequence: |
>PA5493
MSQAPLVLVDGSSYLYRAFHALPPLTTSTGKPTGAVKGVLNMLLSLRKQYPDSPFAVVFDAKGPTFRDELFAEYKANRPSMPDDLRVQVEPLHASVRALGLPLLCVEGVEADDVIGTLARSSAAADRPVVISTGDKDMAQLVDGHITLVNTMTGSRLDVDGVKEKFGVGPELIIDFLALMGDKVDNIPGVPGVGEKTALGLLTGVGGGLEVLYASLDKVPELPIRGAKGLPAKLEENREQAFLSYQLATIKTDVELDVEIDKLYPGEPQREALIALYRELEFKNWLDDLLREAKEAGENGEAETPIQAEVDYDVVLDQAGFDAWLKKLEEAELIAFDTETTSIDAQQAQVVGVSFAVKEGEAAYVPLAHSYMGVPEQLDRDAVLRALKPLLEDPKKLKVGQHAKYDINVLANASTPIALRGVAYDTMLESYVLDSTATRHDMDSLALKYLGHSTIRFEDIAGKGAKQLTFDQIAIEQAGPYAAEDADVTLRLHQALWQKLEAIPSLARVLTDIEMPLVPVLARIERNGALVDANLLGIQSRELGEKMVALERQAYDLAGQEFNLGSPKQLGAILYDKLGLPVLSKTATGQPSTAEAVLAELAEQDFELPKVIMQYRSMSKLKSTYTDRLPEQINPRTGRIHTSYHQAVAATGRLSSSDPNLQNIPIRTAEGRRIRQAFVAPQGYKLLAADYSQIELRIMAHLAKDDGLLDAFRHDLDVHRATAAEVFGVPLEDVSGDQRRSAKAINFGLIYGMSAFGLAKQIGVERKEAQAYIDRYFARYPGVLAYMERTRAQAAEQGFVETLFGRRLYLPEIHSKNGAMRKAAERTAINAPMQGTAADIMKRAMVAVDNWLQESGLDARVILQVHDELVLEVREDLVEQVCEGIRPLMSGAATLDVPLVVEAGVGSNWDEAH |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA5493 and its homologs
|
