Orotate phosphoribosyltransferase (PA5331)

Identification
Name: Orotate phosphoribosyltransferase
Synonyms:
  • OPRT
  • OPRTase
Gene Name: pyrE
Enzyme Class:
Biological Properties
General Function: Involved in orotate phosphoribosyltransferase activity
Specific Function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Orotidylic acid + Pyrophosphate ↔ Orotic acid + Phosphoribosyl pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Orotidylic acid + Pyrophosphate ↔ Orotic acid + Phosphoribosyl pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Orotidylic acid + Pyrophosphate ↔ Phosphoribosyl pyrophosphate + Orotic acid
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SMPDB Reactions:
Thumb+Thumb → Pyrophosphate+Thumb
Orotic acid + Phosphoribosyl pyrophosphate → Pyrophosphate + Orotidylic acid
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Orotidylic acid + Pyrophosphate ↔ Orotic acid + Phosphoribosyl pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Orotidylic acid + Pyrophosphate ↔ Phosphoribosyl pyrophosphate + Orotic acid
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Orotidylic acid + Pyrophosphate → Orotic acid + Phosphoribosyl pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000094Orotic acidMetaboCard
PAMDB000090Orotidylic acidMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
catalytic activity
orotate phosphoribosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
Gene Properties
Locus tag: PA5331
Strand: -
Entrez Gene ID: 878227
Accession: NP_254018.1
GI: 15600524
Sequence start: 6001399
Sequence End: 6002040
Sequence Length: 641
Gene Sequence: 
>PA5331
ATGCAGGCGTATCAGCGCGATTTCATTCGTTTCGCCATCGAGCGCGGGGTTCTGCGCTTCGGTGAGTTCACCCTCAAGTCCGGGCGCACCAGCCCCTATTTCTTCAATGCCGGCCTGTTCGACAGCGGCCTGGCGCTGGCCCGCCTGGGACGCTTCTACGCCGAGGCGGTGATCGACAGCGGAATCGACTTCGACGTCCTGTTCGGCCCGGCCTACAAGGGCATTCCCCTGGCCGCCACCACCGCGGTGGCCCTCGCCGAGCAGCACCAACGCGACCTGCCCTGGTGCTTCAACCGCAAGGAAGCCAAGGACCACGGCGAAGGCGGCACGCTGGTCGGCGCGCCGCTGAGCGGCCGGGTGCTGATCATCGACGACGTGATCACCGCCGGCACCGCGATCCGCGAAGTGATGCAGATCATCGACGCCCAGGGCGCCAGGGCGGCGGGCGTGCTGATCGCGCTGAACCGCCAGGAGCGTGGCAAGGGCGAGCTGTCGGCGATCCAGGAGGTCGAGCGCGACTTCGGCATGCCGGTGGTGAGCATCGTTTCCCTGGAGCAGGTGCTGGAATATCTTGCCGAAGATGCTGAACTGAAGAAGCATCTGCCGGCGGTAGAGGCCTATCGCGCCCAATACGGTATCTGA
Protein Properties
Protein Residues: 213
Protein Molecular Weight: 23.3 kDa
Protein Theoretical pI: 5.12
Hydropathicity (GRAVY score): 0.043
Charge at pH 7 (predicted): -4.31
Protein Sequence: 
>PA5331
MQAYQRDFIRFAIERGVLRFGEFTLKSGRTSPYFFNAGLFDSGLALARLGRFYAEAVIDSGIDFDVLFGPAYKGIPLAATTAVALAEQHQRDLPWCFNRKEAKDHGEGGTLVGAPLSGRVLIIDDVITAGTAIREVMQIIDAQGARAAGVLIALNRQERGKGELSAIQEVERDFGMPVVSIVSLEQVLEYLAEDAELKKHLPAVEAYRAQYGI
References
External Links:
Resource Link
Genome ID: PA5331
Entrez Gene ID: 878227
NCBI Protein ID: 15600524
General Reference: PaperBLAST - Find papers about PA5331 and its homologs