Ubiquinone/menaquinone biosynthesis methyltransferase ubiE (PA5063)

Identification
Name: Ubiquinone/menaquinone biosynthesis methyltransferase ubiE
Synonyms: Not Available
Gene Name: ubiE
Enzyme Class:
Biological Properties
General Function: Involved in methyltransferase activity
Specific Function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Menaquinone+Thumb
2-Demethylmenaquinone 8 + S-Adenosylmethionine ↔ Menaquinone + S-Adenosylhomocysteine
ReactionCard
2-Phytyl-1,4-naphthoquinone+Thumb ↔ Phylloquinone+Thumb
2-Phytyl-1,4-naphthoquinone + S-Adenosylmethionine ↔ Phylloquinone + S-Adenosylhomocysteine
ReactionCard
2-Polyprenyl-6-methoxy-1,4-benzoquinone+Thumb ↔ 2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone+Thumb
2-Polyprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine ↔ 2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosylhomocysteine
ReactionCard
Demethylmenaquinol+Thumb+Thumb ↔ Thumb+Thumb
Demethylmenaquinol + S-Adenosylmethionine + Demethylmenaquinol ↔ Menaquinol 6 + S-Adenosylhomocysteine
ReactionCard
SMPDB Reactions:
Thumb+S-adenosyl-L-methionine → Thumb+Thumb+Thumb
2-Octaprenyl-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine → S-Adenosylhomocysteine + Hydrogen ion + 6-Methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol
ReactionCard
Thumb+S-adenosyl-L-methionine → Thumb+Thumb+Thumb
2-Demethylmenaquinol 8 + S-adenosyl-L-methionine → Hydrogen ion + S-Adenosylhomocysteine + Menaquinol 8
ReactionCard
Thumb+S-adenosyl-L-methionine → 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol +Thumb+Thumb
2-Octaprenyl-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine → 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
2-Demethylmenaquinol 8 + S-Adenosylmethionine → S-Adenosylhomocysteine + Hydrogen ion + Menaquinol 8
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-methoxy-1,4-benzoquinol + S-Adenosylmethionine → 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + S-Adenosylhomocysteine + Hydrogen ion
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
2-Octaprenyl-6-methoxy-1,4-benzoquinol + S-Adenosylmethionine → Hydrogen ion + 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + S-Adenosylhomocysteine
ReactionCard
Thumb+Thumb → Thumb+Thumb+Thumb
2-Demethylmenaquinol 8 + S-Adenosylmethionine → Menaquinol 8 + Hydrogen ion + S-Adenosylhomocysteine
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015632-Demethylmenaquinol 8MetaboCard
PAMDB0015642-Demethylmenaquinone 8MetaboCard
2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinolMetaboCard
PAMDB0015672-Octaprenyl-6-methoxy-1,4-benzoquinolMetaboCard
PAMDB0038266-Methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinolMetaboCard
PAMDB004516DemethylmenaquinolMetaboCard
PAMDB001916Demethylmenaquinone-7MetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001946Menaquinol 6MetaboCard
PAMDB001653Menaquinol 8MetaboCard
PAMDB000610MenaquinoneMetaboCard
PAMDB000205S-AdenosylhomocysteineMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
GO Classification:
Function
catalytic activity
methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Gene Properties
Locus tag: PA5063
Strand: +
Entrez Gene ID: 879743
Accession: NP_253750.1
GI: 15600256
Sequence start: 5702669
Sequence End: 5703439
Sequence Length: 770
Gene Sequence: 
>PA5063
ATGAACGATCCCCGCAAAGGCGCCGACGCCGAACCCACCACCCACTTCGGCTACCAGAACGTTCCGGAAAGCCAGAAGGCGAAGAAGGTCGCCGAGGTATTTCACTCGGTGGCAGCCAAGTACGACCTGATGAACGACCTGATGTCCGGTGGCATCCATCGCCTGTGGAAGCGCTTCACCATCGAGCTGTCCGGCGTGCGCAGCGGGAACCGCGTGCTCGACATCGCCGGCGGCACCGGCGACCTGACCCGGCAGTTCTCGCGCCTGGTCGGCCCGACCGGCGAGGTGGTGCTGGCCGACATCAACGCCTCGATGCTCAAGGTCGGCCGCGACAAGCTGCTCGACAAGGGCGTCTCCGGCAACGTCAGCTTCGTCCAGGCGGACGCCGAGAAGCTGCCCTTCCCGGACAACCACTTCGACTGCGTGACCATCGCCTTCGGCCTGCGCAACGTCACCCACAAGGACGAAGCGATCCGCTCCATGCTGCGCGTGCTCAAGCCCGGTGGCCGCCTGCTGGTGCTGGAGTTCTCCAAGCCGAGCAGCAACCTGCTGTCCAAGGCCTACGACGCCTATTCGTTCAGCCTGCTGCCGCTGATGGGCAAGCTGGTCACCAACGACTCCGAGAGCTATCGCTACCTGGCCGAGTCGATCCGCATGCACCCCGACCAGGAAACCCTGAAGGCGATGATGGTGGAAGCCGGCTTCGACCGCGTGACCTACCACAACATGACCGGCGGCATCGTCGCCCTGCACCGCGGTATCAAGCCTTAA
Protein Properties
Protein Residues: 256
Protein Molecular Weight: 28.3 kDa
Protein Theoretical pI: 9.5
Hydropathicity (GRAVY score): -0.248
Charge at pH 7 (predicted): 5.89
Protein Sequence: 
>PA5063
MNDPRKGADAEPTTHFGYQNVPESQKAKKVAEVFHSVAAKYDLMNDLMSGGIHRLWKRFTIELSGVRSGNRVLDIAGGTGDLTRQFSRLVGPTGEVVLADINASMLKVGRDKLLDKGVSGNVSFVQADAEKLPFPDNHFDCVTIAFGLRNVTHKDEAIRSMLRVLKPGGRLLVLEFSKPSSNLLSKAYDAYSFSLLPLMGKLVTNDSESYRYLAESIRMHPDQETLKAMMVEAGFDRVTYHNMTGGIVALHRGIKP
References
External Links:
Resource Link
Genome ID: PA5063
Entrez Gene ID: 879743
NCBI Protein ID: 15600256
General Reference: PaperBLAST - Find papers about PA5063 and its homologs