ADP-ribose pyrophosphatase (PA4971)

Identification
Name: ADP-ribose pyrophosphatase
Synonyms:
  • ADP-ribose diphosphatase
  • ADP-ribose phosphohydrolase
  • ASPPase
  • Adenosine diphosphoribose pyrophosphatase
  • ADPR-PPase
Gene Name: nudF
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Specific Function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+2 Thumb+Thumb
Adenosine diphosphate ribose + Water ↔ Adenosine monophosphate + 2 Hydrogen ion + D-Ribose-5-phosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine diphosphate ribose + Water ↔ Adenosine monophosphate + D-Ribose-5-phosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+2 Thumb+Thumb
Adenosine diphosphate ribose + Water ↔ Adenosine monophosphate + 2 Hydrogen ion + D-Ribose-5-phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose-5-phosphate
ReactionCard
Thumb+Thumb → Thumb+Thumb
Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose-5-phosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000285Adenosine diphosphate riboseMetaboCard
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000431D-Ribose-5-phosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ion binding
metal ion binding
Gene Properties
Locus tag: PA4971
Strand: -
Entrez Gene ID: 879756
Accession: NP_253658.1
GI: 15600164
Sequence start: 5580102
Sequence End: 5580719
Sequence Length: 617
Gene Sequence: 
>PA4971
ATGTCCGAAACCTTCAAACCCGCCCCCGGTGACGTCGAACTCGTGCAGCGCGAGGAATGCTTCCGTGGCTTCTATCGTCTCGATCGCCTGCGCCTGCGGCATCGCCAGTTCGACGGCAGCATGGGCCGGGAAATCAGTCGGGAACTGTTCGTCCGCCATGACGCGGTCTGCGTGCTGCCCTACGACCCGCAGCGCGATTGCGTGGTGCTCATCGAGCAATTCCGCGTCGGGGCGATGCAGAAGCTCGCCAACCCCTGGCTGCTGGAGCTGGTCGCCGGCCTGATCGACAAGGACGAGCAACCGGAGGAAGTGGCCCATCGCGAGGCGATGGAGGAGGCCGGGCTGACTCTCGGTGCGCTCTGGCCGATAACCCAGTACCTGCCGTCGCCGGGCGGCACCGACGAAGTGGTGCACCTGTTCGTCGGCCGTTGCGACAGCGAAGGCGTCGGCGGCGTGCATGGCTTGCCGGAGGAGGGCGAGGACATCCGCGTCCACGTCTGGCCGTTGGAAGATGCGCTGCAGGCCGTGCGCGACGGGCGGATCAACAACGCGGCGAGCATCATCGCCCTGCAGTGGCTGGCCCTGAACCGGGCCGAGGTGCGTGGGCTATGGGCCTGA
Protein Properties
Protein Residues: 205
Protein Molecular Weight: 23.1 kDa
Protein Theoretical pI: 4.7
Hydropathicity (GRAVY score): -0.229
Charge at pH 7 (predicted): -10.67
Protein Sequence: 
>PA4971
MSETFKPAPGDVELVQREECFRGFYRLDRLRLRHRQFDGSMGREISRELFVRHDAVCVLPYDPQRDCVVLIEQFRVGAMQKLANPWLLELVAGLIDKDEQPEEVAHREAMEEAGLTLGALWPITQYLPSPGGTDEVVHLFVGRCDSEGVGGVHGLPEEGEDIRVHVWPLEDALQAVRDGRINNAASIIALQWLALNRAEVRGLWA
References
External Links:
Resource Link
Genome ID: PA4971
Entrez Gene ID: 879756
NCBI Protein ID: 15600164
General Reference: PaperBLAST - Find papers about PA4971 and its homologs