Inosine-5'-monophosphate dehydrogenase (PA3770)

Identification
Name: Inosine-5'-monophosphate dehydrogenase
Synonyms:
  • IMP dehydrogenase
  • IMPD
  • IMPDH
Gene Name: guaB
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Water + Inosinic acid + NAD ↔ Hydrogen ion + NADH + Xanthylic acid
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Inosinic acid + NAD + Water ↔ Xanthylic acid + NADH + Hydrogen ion
ReactionCard
6-Thioinosine-5'-monophosphate+Thumb+Thumb ↔ 6-Thioxanthine 5'-monophosphate+Thumb+Thumb
6-Thioinosine-5'-monophosphate + NAD + Water ↔ 6-Thioxanthine 5'-monophosphate + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Water + NAD + Inosinic acid → Hydrogen ion + NADH + Xanthylic acid
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Inosinic acid + NAD + Water → NADH + Hydrogen ion + Xanthylic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Water + Inosinic acid + NAD ↔ Hydrogen ion + NADH + Xanthylic acid
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Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Water + NAD + Inosinic acid → Hydrogen ion + NADH + Xanthylic acid
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Inosinic acid + NAD + Water → Xanthylic acid + NADH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001633Hydrogen ionMetaboCard
PAMDB000601Inosinic acidMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000142WaterMetaboCard
PAMDB000419Xanthylic acidMetaboCard
GO Classification:
Function
catalytic activity
IMP dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA3770
Strand: -
Entrez Gene ID: 880535
Accession: NP_252459.1
GI: 15598965
Sequence start: 4227317
Sequence End: 4228786
Sequence Length: 1469
Gene Sequence: 
>PA3770
ATGCTGCGAATCAGTCAAGAAGCCCTGACTTTCGACGACGTCCTTCTGATCCCCGGTTATTCCGAAGTCCTGCCCAAGGACGTGAGTTTGAAAACTCGCCTGACCCGCGGCATCGAACTGAACATCCCGCTGGTATCCGCCGCGATGGATACCGTGACCGAAGCCCGCCTGGCCATCGCCATGGCCCAGGAAGGCGGCATCGGCATCATCCACAAGAACATGGGCATCGAGCAGCAGGCCGCGGAAGTCCGCAAGGTCAAGAAGCACGAAACGGCCATCGTCCGCGACCCGGTCACCGTGACCCCCTCGACCAAGATCATCGAACTGCTGCAGATGGCCCGCGAGTACGGCTTCTCCGGTTTCCCGGTGGTGGAGCAGGGCGAGCTGGTCGGTATCGTCACCGGTCGCGACCTGCGGGTGAAGCCGAACGCCGGCGATACCGTCGCCGCGATCATGACCCCGAAGGACAAGCTGGTCACCGCCCGCGAAGGCACCCCGCTGGAAGAGATGAAGGCCAAGCTCTACGAGAACCGCATCGAGAAGATGCTGGTGGTCGACGAGAACTTCTACCTGCGTGGCCTGGTGACCTTCCGTGACATCGAGAAGGCCAAGACCTACCCGCTGGCGTCCAAGGACGAGCAGGGCCGCCTGCGCGTCGGCGCCGCCGTCGGCACCGGCGCCGATACCGGCGAGCGCGTTGCCGCGCTGGTCGCCGCCGGGGTCGACGTGGTGGTGGTGGACACCGCCCACGGCCACTCCAAGGGCGTGATCGAGCGTGTGCGCTGGGTCAAGCAGACCTTCCCGGACGTCCAGGTGATCGGCGGCAACATCGCCACCGCCGAGGCCGCCAAGGCCCTCGCCGAGGCTGGCGCCGACGCGGTCAAGGTCGGCATCGGCCCGGGCTCGATCTGCACCACCCGCATCGTCGCCGGTGTCGGCGTGCCGCAGATCTCCGCCATCGCCAACGTTGCCGCCGCCCTCGAAGGCACCGGCGTACCGCTGATCGCCGACGGCGGCATCCGCTTCTCCGGCGACCTGGCCAAGGCCATGGTCGCCGGCGCCTACTGTGTGATGATGGGCTCGATGTTCGCCGGTACCGAGGAAGCGCCGGGCGAGATCGAGCTGTTCCAGGGCCGTTCCTACAAGTCCTACCGCGGCATGGGTTCGCTGGGCGCCATGTCCGGCTCCCAGGGCTCGTCCGACCGCTACTTCCAGGACGCCTCCGCCGGCGCCGAGAAGCTGGTGCCGGAAGGCATCGAGGGTCGCGTGCCGTACAAGGGTGCCCTGTCCGCCATCGTCCACCAGCTGATGGGCGGCCTGCGCGCCGCCATGGGCTACACCGGCAGCGCCGACATCCAGCAGATGCGCACGCAGCCGCAGTTCGTCCGGATCACCGGCGCGGGCATGGCCGAGTCCCATGTCCACGACGTCCAGATCACCAAGGAAGCCCCCAACTACCGGGTTGGTTGA
Protein Properties
Protein Residues: 489
Protein Molecular Weight: 51.7 kDa
Protein Theoretical pI: 6.65
Hydropathicity (GRAVY score): 0.027
Charge at pH 7 (predicted): -1.36
Protein Sequence: 
>PA3770
MLRISQEALTFDDVLLIPGYSEVLPKDVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIAMAQEGGIGIIHKNMGIEQQAAEVRKVKKHETAIVRDPVTVTPSTKIIELLQMAREYGFSGFPVVEQGELVGIVTGRDLRVKPNAGDTVAAIMTPKDKLVTAREGTPLEEMKAKLYENRIEKMLVVDENFYLRGLVTFRDIEKAKTYPLASKDEQGRLRVGAAVGTGADTGERVAALVAAGVDVVVVDTAHGHSKGVIERVRWVKQTFPDVQVIGGNIATAEAAKALAEAGADAVKVGIGPGSICTTRIVAGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLAKAMVAGAYCVMMGSMFAGTEEAPGEIELFQGRSYKSYRGMGSLGAMSGSQGSSDRYFQDASAGAEKLVPEGIEGRVPYKGALSAIVHQLMGGLRAAMGYTGSADIQQMRTQPQFVRITGAGMAESHVHDVQITKEAPNYRVG
References
External Links:
Resource Link
Genome ID: PA3770
Entrez Gene ID: 880535
NCBI Protein ID: 15598965
General Reference: PaperBLAST - Find papers about PA3770 and its homologs