Identification
Name: PTS system N-acetylglucosamine-specific EIICBA component
Synonyms:
  • EIICBA-Nag
  • EII-Nag
  • N-acetylglucosamine permease IIC component
  • PTS system N-acetylglucosamine-specific EIIC component
  • N-acetylglucosamine-specific phosphotransferase enzyme IIB component
  • PTS system N-acetylglucosamine-specific EIIB component
  • N-acetylglucosamine-specific phosphotransferase enzyme IIA component
  • PTS system N-acetylglucosamine-specific EIIA component
Gene Name: nagE
Enzyme Class:
Biological Properties
General Function: Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Protein N(pi)-phospho-L-histidine+ThumbProtein histidine+Thumb
Protein N(pi)-phospho-L-histidine + N-Acetyl-D-glucosamine ↔ Protein histidine + N-Acetyl-D-Glucosamine 6-Phosphate
ReactionCard
Protein EIIB N(pi)-phospho-L-histidine/cysteine+Thumbprotein EIIB+sugar phosphate
Protein EIIB N(pi)-phospho-L-histidine/cysteine + Sucrose → protein EIIB + sugar phosphate
ReactionCard
N-Acetyl-D-glucosamine+HPr - phosphorylated+ThumbN-Acetyl-D-Glucosamine 6-Phosphate+HPr+Thumb
N-Acetyl-D-glucosamine + HPr - phosphorylated + N-Acetylglucosamine → N-Acetyl-D-Glucosamine 6-Phosphate + HPr + N-Acetyl-D-Glucosamine 6-Phosphate
ReactionCard
Complex Reactions: Not Available
Transports:
Metabolites:
PAMDB IDNameView
PAMDB000088N-Acetyl-D-glucosamineMetaboCard
PAMDB000238N-Acetyl-D-Glucosamine 6-PhosphateMetaboCard
PAMDB001956N-AcetylglucosamineMetaboCard
PAMDB000111Phosphoenolpyruvic acidMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000109SucroseMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane
membrane part
organelle inner membrane
organelle membrane
Function
carbohydrate transmembrane transporter activity
cation transmembrane transporter activity
cation:sugar symporter activity
ion transmembrane transporter activity
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
solute:cation symporter activity
substrate-specific transmembrane transporter activity
sugar:hydrogen symporter activity
transmembrane transporter activity
transporter activity
Process
carbohydrate transport
establishment of localization
phosphoenolpyruvate-dependent sugar phosphotransferase system
transport
Gene Properties
Locus tag: PA3761
Strand: +
Entrez Gene ID: 880500
Accession: NP_252450.1
GI: 15598956
Sequence start: 4212848
Sequence End: 4214560
Sequence Length: 1712
Gene Sequence:
>PA3761
ATGCCCCCGTTCCTGATCGAAAGCCTGCAACGCCTGGGCCGCGCCCTGATGCTGCCGATCGCGATCCTGCCGATCGCCGGCCTGCTGCTGCGCCTGGGCGACGTCGACCTGCTCGACATTCCGCTGGTCCACGACGCCGGCAAGGCGATCTTCGCCAACCTGGCGCTGATCTTCGCCATCGGCATCGCCGTCGGTTTCGCTCGCGACAACAATGGCACCGCCGGCCTCGCCGGCGCCATCGGCTACCTGGTGATGATCTCGGTGCTCAAGGTGATCGATCCGGGCATCGACATGGGCGTGCTCTCCGGCATCATCAGCGGCCTGGTGGCTGGCGCCCTGTATAACCGCTTCAAGGACGTGAAGCTGCCGGAATACCTGGCGTTCTTCGGCGGCCGCCGCTTCGTGCCGATCGCCACCGGGATCAGCGCGGTCTGCCTGGGCCTGCTGTTCGGGGTGATCTGGCCACCGCTGCAACAGGGCATCAACGGCCTCGGCCAACTCATGCTGGAAAGCGGCAGCTTCGGCGCCTTCGCCTTCGGCGTGCTGAACCGCCTGCTGATCGTCACCGGGTTGCACCACATCCTCAACAACCTGGTGTGGTTCGTCTTCGGTAGCTTCACCGACCCGGAAACCGGGCGCGTCGTCACCGGCGACCTGGCGCGCTATTTCGCCGGCGACCCGAAGGGCGGCCAGTTCATGGCCGGGATGTTCCCGGTGATGATGTTCGGCCTGCCCGCCGCCTGCCTGGCGATGTACCGCAACGCCCGTCCGGAGCGGCGCAAGCTGATCGGCGGGCTGCTCCTGTCGATGGCCTTGACCGCCTTCCTCACCGGCGTCACCGAGCCGGTGGAGTTCGCCTTCATGTTCCTCGCGCCGCTGCTCTACCTGCTGCATGCGCTGCTCACCGGCCTGTCCATGGCCCTCACCGACCTGCTCGATATCCGCCTCGGCTTCACCTTCTCCGGTGGCGCCATCGACCTCGCCCTGGGCTGGGGCCGTTCCACCCACGGCTGGATGCTCTGGCCGCTGGGCCTGCTCTATGCCGGCATCTATTACCTGGTGTTCGACTTCTGCATCCGCCGCTTCAACCTGAAGACCCCGGGCCGCGAAGACGACGCGAGCAGCGAATCGGGCGACAACGCCGAAGCCGAGCGCGCCCCGGCATTCATCCGCGCCTTGGGTGGCGCAGCCAACCTCGAAGTGGTGGACGCCTGCACCACGCGCCTGCGTCTGCGCCTGGTCGACCGCAACAAGGCCTCGGACGCCCAACTCAAGGCCCTCGGTGCGATGGCCGTGGTACGTCCGGGCAAGGCCGGCAGCCTGCAGGTGGTGGTCGGCCCACAGGCCGACAGCATCGCCGACGAGATCCGCCGCGCCCTGCCCTTCGATACGCAACCGGGCGAAGCCGTACCGCCGCTGGGCAGTCCGCACACAGCCGAAGAGGTGGTGGCGATGCAGGCCACCGTCGACGCCGCCGAAGCCCAGGCCTGGCTCGGCGCCCTCGGCGGCGCCGGCAACCTGCGCGAGGTACGGGACGTCGCACTGACCCGCCTGCGGGTCAGCGTGGCGGACGAACGCAAGCTGGCCACCGAGCAACTGCGTCGTCTCGGCGGACAGGGCGTCAGTTCCCTCGCCGGCGGCATCTGCCATATCCTGGTGGGCCCCCGCGCCGCGGCCCTGAGCCAGGCCCTGCAACCGCTGCTGCGGCGCTGA
Protein Properties
Protein Residues: 570
Protein Molecular Weight: 60.6 kDa
Protein Theoretical pI: 8.21
Hydropathicity (GRAVY score): 0.485
Charge at pH 7 (predicted): 3.54
Protein Sequence:
>PA3761
MPPFLIESLQRLGRALMLPIAILPIAGLLLRLGDVDLLDIPLVHDAGKAIFANLALIFAIGIAVGFARDNNGTAGLAGAIGYLVMISVLKVIDPGIDMGVLSGIISGLVAGALYNRFKDVKLPEYLAFFGGRRFVPIATGISAVCLGLLFGVIWPPLQQGINGLGQLMLESGSFGAFAFGVLNRLLIVTGLHHILNNLVWFVFGSFTDPETGRVVTGDLARYFAGDPKGGQFMAGMFPVMMFGLPAACLAMYRNARPERRKLIGGLLLSMALTAFLTGVTEPVEFAFMFLAPLLYLLHALLTGLSMALTDLLDIRLGFTFSGGAIDLALGWGRSTHGWMLWPLGLLYAGIYYLVFDFCIRRFNLKTPGREDDASSESGDNAEAERAPAFIRALGGAANLEVVDACTTRLRLRLVDRNKASDAQLKALGAMAVVRPGKAGSLQVVVGPQADSIADEIRRALPFDTQPGEAVPPLGSPHTAEEVVAMQATVDAAEAQAWLGALGGAGNLREVRDVALTRLRVSVADERKLATEQLRRLGGQGVSSLAGGICHILVGPRAAALSQALQPLLRR
References
External Links:
Resource Link
Genome ID: PA3761
Entrez Gene ID: 880500
NCBI Protein ID: 15598956
General Reference: PaperBLAST - Find papers about PA3761 and its homologs