methylmalonate-semialdehyde dehydrogenase (PA3570)

Identification
Name: methylmalonate-semialdehyde dehydrogenase
Synonyms: Not Available
Gene Name: mmsA
Enzyme Class: Not Available
Biological Properties
General Function: cellular amino acid metabolic process, isoleucine catabolic process, leucine catabolic process, carbon utilization, propionate metabolic process, cellular catabolic process, metabolic process, oxidation-reduction process
Specific Function: amidase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, oxidoreductase activity, methylmalonate-semialdehyde dehydrogenase (acylating) activity
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O → propanoyl-CoA + hydrogen carbonate + NADH + H+
ReactionCard
Thumb
methylmalonate semialdehyde + coenzyme A + NAD+ + H2O = propanoyl-CoA + hydrogen carbonate + NADH + H+
ReactionCard
PAMDB110827+PAMDB110248+PAMDB110542 → PAMDB110382+PAMDB000568+PAMDB110540
3-oxopropanoate + coenzyme A + NAD+ → acetyl-CoA + Carbon dioxide + NADH
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites: Not Available
GO Classification:
Function
amidase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity
methylmalonate-semialdehyde dehydrogenase (acylating) activity
Process
cellular amino acid metabolic process
isoleucine catabolic process
leucine catabolic process
carbon utilization
propionate metabolic process
cellular catabolic process
metabolic process
oxidation-reduction process
Gene Properties
Locus tag: PA3570
Strand: -
Entrez Gene ID: 878814
Accession: NP_252260.1
GI: 15598766
Sequence start: 4002108
Sequence End: 4003601
Sequence Length: 1493
Gene Sequence: 
>PA3570
ATGTCAGTCCCAGTCCGCCACCTCATCGCGGGAGCCTTCGTCGAAGGTCTCGGCGCCCAGCGCATCCCGGTCAGCAATCCCCTCGACAACAGCACCCTGGCGGAGATCGCCTGCGCCAGCGCGGAGCAGGTCGAGCAGGCGGTGGCCAGTGCCCGCGAAACCTTCGCCAGCTGGAAGGAAACCCCGGTTTCCGAGCGCGCGCGGGTGATGCTGCGTTACCAGGCGTTGCTCAAGGAACACCACGACGAACTGGCGAAGATCGTCTCCAGCGAGCTGGGCAAGACTTTCGAGGACGCCAAGGGCGACGTCTGGCGCGGTATCGAGGTGGTCGAACACGCCTGCAACGTGCCCTCGCTGCTGATGGGCGAGACGGTGGAGAACGTCGCCCGCAACATCGACACCTACAGCATCACCCAGCCGCTGGGCGTGTGCGTTGGCATCACCCCGTTCAACTTCCCGGCGATGATCCCGCTGTGGATGTTCCCGCTGGCCATCGCCTGCGGCAACGCCTTCATCCTCAAGCCTTCCGAGCAGGTGCCGCTGACCAGCGTGCGGCTCGCCGAGCTGTTCCTCGAGGCCGGTGCGCCGAAGGGCGTGCTGCAGGTGGTGCATGGCGGCAAGGAACAGGTCGACCAGTTGCTCAAGCACCCGCAGGTGAAGGCGGTGTCCTTCGTCGGCTCGGTCGCCGTCGGCCAGTACGTCTACCACACCGGCACCGCGCACAATAAGCGCGTGCAGAGCTTCGCCGGGGCGAAGAACCACATGGTGATCATGCCCGACGCGGACAAGGCACAGGTCATCAGCAACCTGGTCGGTGCCTCGGTGGGCGCGGCCGGGCAGCGCTGCATGGCGATCTCGGTGGCGGTGCTGGTGGGGGCCGCCCGCGAGTGGATTCCGGAAATCCGCGACGCGCTGGCCAAGGTCCGCCCCGGCCCATGGGACGACAGCGGCGCCAGCTACGGCCCGGTGATCAACCCGCAGGCCAAGGCGCGCATCGAGCGCCTGATCGGCCAGGGCGTGGAGGAGGGCGCGCAACTGCTGCTGGATGGCCGCGGCTACAAGGTCGAGGGATACCCGGACGGCAACTGGGTCGGCCCGACGCTGTTCGCCGGGGTGCGCCCGGACATGGCGATCTACCGCGAAGAGGTGTTCGGCCCGGTGCTCTGCCTGGCCGAGGTCGACAGCCTGGAGCAGGCGATCCGCCTGATCAACGAAAGCCCCTACGGCAACGGCACCTCGATCTTCACCAGCTCCGGCGCCGCGGCGCGGACCTTCCAGCACCACATCGAGGTCGGCCAGGTGGGCATCAACATCCCGATTCCGGTACCGCTGCCGTTCTTCTCCTTCACCGGTTGGAAGGGCTCGTTCTACGGCGACCTGCACGCCTACGGCAAGCAGGGCGTGCGCTTCTACACCGAGACCAAGACCGTGACCGCGCGCTGGTTCGACAGCGACAGCGTGGCCGGGACCAACTTCTCGATCCAGATGCGCTGA
Protein Properties
Protein Residues: 497
Protein Molecular Weight: 53.7 kDa
Protein Theoretical pI: 6.38
Hydropathicity (GRAVY score): 0.031
Charge at pH 7 (predicted): -4.28
Protein Sequence: 
>PA3570
MSVPVRHLIAGAFVEGLGAQRIPVSNPLDNSTLAEIACASAEQVEQAVASARETFASWKETPVSERARVMLRYQALLKEHHDELAKIVSSELGKTFEDAKGDVWRGIEVVEHACNVPSLLMGETVENVARNIDTYSITQPLGVCVGITPFNFPAMIPLWMFPLAIACGNAFILKPSEQVPLTSVRLAELFLEAGAPKGVLQVVHGGKEQVDQLLKHPQVKAVSFVGSVAVGQYVYHTGTAHNKRVQSFAGAKNHMVIMPDADKAQVISNLVGASVGAAGQRCMAISVAVLVGAAREWIPEIRDALAKVRPGPWDDSGASYGPVINPQAKARIERLIGQGVEEGAQLLLDGRGYKVEGYPDGNWVGPTLFAGVRPDMAIYREEVFGPVLCLAEVDSLEQAIRLINESPYGNGTSIFTSSGAAARTFQHHIEVGQVGINIPIPVPLPFFSFTGWKGSFYGDLHAYGKQGVRFYTETKTVTARWFDSDSVAGTNFSIQMR
References
External Links:
Resource Link
Genome ID: PA3570
Entrez Gene ID: 878814
NCBI Protein ID: 15598766
General Reference: PaperBLAST - Find papers about PA3570 and its homologs