Dihydrofolate reductase folM (PA3437)

Identification
Name: Dihydrofolate reductase folM
Synonyms:
  • DHFR
Gene Name: folM
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Dihydrofolic acid + Hydrogen ion + NADPH ↔ NADP + Tetrahydrofolic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Tetrahydrofolic acid + NAD ↔ Dihydrofolic acid + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Tetrahydrofolic acid + NADP ↔ Dihydrofolic acid + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
7,8-dihydrofolate monoglutamate+Thumb+NADPH+Thumb+Thumb → Thumb+Tetrahydrofolic acid+Thumb
7,8-dihydrofolate monoglutamate + Hydrogen ion + NADPH + Dihydrofolic acid + NADPH → NADP + Tetrahydrofolic acid + Tetrahydrofolic acid
ReactionCard
Dihydromethysticin+Thumb+Thumb → Thumb+Thumb
Dihydromethysticin + NADPH + Hydrogen ion → Tetrahydromonapterin + NADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Dihydrofolic acid + Hydrogen ion + NADPH ↔ NADP + Tetrahydrofolic acid
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb
7,8-Dihydroneopterin + Hydrogen ion + NADPH → NADP + Tetrahydromonapterin
ReactionCard
Thumb+Thumb ← Thumb+Thumb+Thumb
NADP + Tetrahydrofolic acid ← Hydrogen ion + NADPH + Dihydrofolic acid
ReactionCard
Thumb+Thumb ← Thumb+Thumb+Thumb
Tetrahydromonapterin + NADP ← Hydrogen ion + 7,8-Dihydroneopterin + NADPH
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Tetrahydrofolic acid + NADP → Dihydrofolic acid + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0004547,8-DihydroneopterinMetaboCard
PAMDB000235Dihydrofolic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB001694TetrahydromonapterinMetaboCard
GO Classification:
Function
binding
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA3437
Strand: +
Entrez Gene ID: 878764
Accession: NP_252127.1
GI: 15598633
Sequence start: 3845053
Sequence End: 3845757
Sequence Length: 704
Gene Sequence: 
>PA3437
ATGGCGACAGCCCCGATCCTGATCACCGGCGCCAGCCAGCGTGTCGGCCTGCATTGCGCCCGCCGCCTGCTGGCCGACGGCGAGTCGGTGATCGTCAGCTACCGCAGCGAACGCCCGGCGCTGGACGAACTGCGCCAGGCCGGCGCGCTGACCCTGCACGCCGACTTCGCCAGCGAGGCCGGCATCTTCGCCTTCATCGGGGCCCTCCGACAGCATACCGACAGCCTGCGAGCGATCGTCCACAACGCCTCGGACTGGGTCGCCGAGACGCCCGGCCACGAAGCCGAGGCGTTCCAGCAACTGTTCAGCGTGCACATGCTCGCGCCCTACCTGATCAACCTGCACTGCGCCGAGCTGCTGGAACGCTCGCAGCCCGCCGACATCGTCCACCTCACCGACGACGTGGCGCGCAAGGGCAGCGCCCGGCGTATCGCCTACTGCGCGAGCAAGGCCGGGCTGGACAACCTGACCCTGTCGTTCGCCGCGCGCTTCGCGCCGAGGATCAAGGTCAACGCCATTTCACCGGCACTGGTGATGTTCAACGACGGGGACGATGCCGAATACCGCGCCCGCACCCTGGCGAAATCCGCCCTCGGCATCGAACCGGGGCCGGAAGTCATCTACCAGAGCCTTCGCTACCTGTTGGACAACCCCTACGTCACCGGGACCACCCTGACCGTGAACGGCGGCCGCCACGTCAAGTGA
Protein Properties
Protein Residues: 234
Protein Molecular Weight: 25.4 kDa
Protein Theoretical pI: 7.02
Hydropathicity (GRAVY score): 0.001
Charge at pH 7 (predicted): 0.07
Protein Sequence: 
>PA3437
MATAPILITGASQRVGLHCARRLLADGESVIVSYRSERPALDELRQAGALTLHADFASEAGIFAFIGALRQHTDSLRAIVHNASDWVAETPGHEAEAFQQLFSVHMLAPYLINLHCAELLERSQPADIVHLTDDVARKGSARRIAYCASKAGLDNLTLSFAARFAPRIKVNAISPALVMFNDGDDAEYRARTLAKSALGIEPGPEVIYQSLRYLLDNPYVTGTTLTVNGGRHVK
References
External Links:
Resource Link
Genome ID: PA3437
Entrez Gene ID: 878764
NCBI Protein ID: 15598633
General Reference: PaperBLAST - Find papers about PA3437 and its homologs