P. aeruginosa Metabolome Database Protein PA3415

Identification

Name:

probable dihydrolipoamide acetyltransferase

Synonyms:

Not Available

Gene Name:

Not Available

Enzyme Class:

Not Available

Biological Properties

General Function:

metabolic process

Specific Function:

transferase activity, transferring acyl groups

Cellular Location:

Cytoplasmic

KEGG Pathways:

lactate oxidation LCTACACAT-PWY
2-oxoisovalerate decarboxylation to isobutanoyl-CoA PWY-5046

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

glycine + a tetrahydrofolate + NAD⁺ → a 5,10-methylene-tetrahydrofolate + ammonium + CO₂ + NADH
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pyruvate + coenzyme A + NAD⁺ → acetyl-CoA + CO₂ + NADH
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pyruvate + lipoamide → S-acetyldihydrolipoamide + CO₂
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acetyl-CoA + dihydrolipoamide ← S-acetyldihydrolipoamide + coenzyme A
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2-oxoglutarate + coenzyme A + NAD⁺ → succinyl-CoA + CO₂ + NADH
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a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate ↔ a [glycine-cleavage complex H protein] N⁶-dihydrolipoyl-L-lysine + a 5,10-methylene-tetrahydrofolate + ammonium
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glycine + a [glycine-cleavage complex H protein] N⁶-lipoyl-L-lysine + H⁺ ↔ a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + CO₂
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succinyl-lipoate + coenzyme A → succinyl-CoA + DIHYDROLIPOYL-OXO-GLUT-E2
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a [lipoyl-carrier protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺ = a [lipoyl-carrier protein]-N⁶-lipoyl-L-lysine + NADH + H⁺
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2-oxoglutarate + a [2-oxoglutarate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + H⁺ → a [2-oxoglutarate dehydrogenase E2 protein] N⁶-S-succinyldihydrolipoyl-L-lysine + CO₂
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BCAA-dehydrogenase-lipoyl

→

BCAA-dehydrogenase-2MB-DH-lipoyl

2-Keto-3-methyl-valerate + BCAA-dehydrogenase-lipoyl → BCAA-dehydrogenase-2MB-DH-lipoyl + Carbon dioxide
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Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

Not Available

GO Classification:

Function
transferase activity, transferring acyl groups
Process
metabolic process

Gene Properties

Locus tag:

PA3415

Strand:

Entrez Gene ID:

878691

Accession:

NP_252105.1

GI:

15598611

Sequence start:

3821385

Sequence End:

3822497

Sequence Length:

1112

Gene Sequence:

>PA3415
ATGAAGCACTTCAAGCTGCCCGACCTGGGCGAGGGCCTACAGGAAGCGGAAATCGTCGAATGGCACGTCAAGGCCGGCGACAGCGTGCGCGCCGACCAGCGCCTGGTCTCGGTGGAAACCGCCAAGGCGCTGGTGGACATCCCCGCGCCCTACGATGGGGTGGTGGGCAAGCTGTTCGGCGCCGAGGGCGACATCCTCCACGTCGGCGAACCGCTGGTGGGCTTCGAGGGCGAGGAGGCGGACGCCGGTACCGTGGTGGGGCGCCTGGAGGGCGGCGGTAGCGCCCTGGAGGACCGTTTCTTCATCGGCGCCGCACCGTCCACCCGCGAGCACCTGGCACCGCGCGCGACCCCGGCGGTGCGCCAGTTCGCCCGCCAGCAGGGCGTCGAGCTGGCCGGCCTGAGCGGCTCCGGCCCGGATGGCCTGATCACCCGCGCCGACGTCGAGGCCGCCGCCCAGGGCACCCGCGAACGCTTCGGCGGCGAGCGCTTGCGCGGGGTACGGCGGAGCATGGCGCTGAACATGGCGCGCTCGCATGCCGAGGTGGTGCCGGTGACGATCTACGGCGACGCCGACCTGCATCGCTGGAAGACCGCACGCGACCCGTTGATCCGCCTGGCCCAGGCGCTGGCCGAGGCCTGTCGCGCCGAGCCGACCCTCAACGCCTGGTTCGATGGCGCCTCGTTGTCGCTGAAACTGCATGAGCGGCTCGACCTGGGGATCGCCGTGGACACCCCGGACGGCCTGTTCGTGCCGGTGCTGCGCGACGTCGGTGCGCGTTCGGCGGAGGACCTGCGCGCCGGTATGCGGCGCCTGCGCGAAGACGTCCAGGCACGCTCGATCCCACCGGCGGAAATGCTCGGCGCGACCCTGACCCTATCCAACTTCGGCACCCTGTTCGGCCGCTACGCCAACCCCGTGGTGGTGCCGCCGCAGGTGGCCATCCTCGGCGCCGGCGGCATCCGCGACGAAGTAGTGGCCTGGCGCGGCGAGATGGCGATCCACCCGATCCTGCCGCTCTCGCTGAGCTTCGATCACCGCGCCGCCACCGGTGGCGAGGCGGCGCGTTTCCTCAAGGTACTGGTGAACGCCCTGGAGCAGCCCGACGGCTGA

Protein Properties

Protein Residues:

370

Protein Molecular Weight:

39.5 kDa

Protein Theoretical pI:

5.47

Hydropathicity (GRAVY score):

-0.081

Charge at pH 7 (predicted):

-7.84

Protein Sequence:

>PA3415
MKHFKLPDLGEGLQEAEIVEWHVKAGDSVRADQRLVSVETAKALVDIPAPYDGVVGKLFGAEGDILHVGEPLVGFEGEEADAGTVVGRLEGGGSALEDRFFIGAAPSTREHLAPRATPAVRQFARQQGVELAGLSGSGPDGLITRADVEAAAQGTRERFGGERLRGVRRSMALNMARSHAEVVPVTIYGDADLHRWKTARDPLIRLAQALAEACRAEPTLNAWFDGASLSLKLHERLDLGIAVDTPDGLFVPVLRDVGARSAEDLRAGMRRLREDVQARSIPPAEMLGATLTLSNFGTLFGRYANPVVVPPQVAILGAGGIRDEVVAWRGEMAIHPILPLSLSFDHRAATGGEAARFLKVLVNALEQPDG

References

External Links:

Resource	Link
Genome ID:	PA3415
Entrez Gene ID:	878691
NCBI Protein ID:	15598611

General Reference:

PaperBLAST - Find papers about PA3415 and its homologs

probable dihydrolipoamide acetyltransferase (PA3415)