P. aeruginosa Metabolome Database Protein PA0898

Identification

Name:

N-succinylglutamate 5-semialdehyde dehydrogenase

Synonyms:

Succinylglutamic semialdehyde dehydrogenase
SGSD

Gene Name:

astD

Enzyme Class:

1.2.1.71

Biological Properties

General Function:

Involved in oxidoreductase activity

Specific Function:

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdehyde as the electron donor and NAD as the electron acceptor. No activity is detected with NADP as the electron acceptor. Therefore, is an aldehyde dehydrogenase with broad substrate specificity

Cellular Location:

Not Available

KEGG Pathways:

Arginine and proline metabolism pae00330

KEGG Reactions:

↔

Water + NAD + N2-Succinyl-L-glutamic acid 5-semialdehyde ↔ 2 Hydrogen ion + NADH + N-Succinyl-L-glutamate
ReactionCard

↔

N2-Succinyl-L-glutamic acid 5-semialdehyde + NAD + Water ↔ N-Succinyl-L-glutamate + NADH + Hydrogen ion
ReactionCard

SMPDB Reactions:

→

N2-succinylglutamate

N2-Succinyl-L-glutamic acid 5-semialdehyde + Water + NAD → 2 Hydrogen ion + NADH + N2-succinylglutamate + N2-succinylglutamate
ReactionCard

PseudoCyc/BioCyc Reactions:

→

N²-succinylglutamate

N2-Succinyl-L-glutamic acid 5-semialdehyde + NAD + Water → N²-succinylglutamate + NADH + Hydrogen ion
ReactionCard

Complex Reactions:

→

N2-Succinyl-L-glutamic acid 5-semialdehyde + NAD + Water → N-Succinyl-L-glutamate + NADH
ReactionCard

Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB006308	N2-succinylglutamate	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB000387	N-Succinyl-L-glutamate	MetaboCard
PAMDB000287	N2-Succinyl-L-glutamic acid 5-semialdehyde	MetaboCard
PAMDB000197	NAD	MetaboCard
PAMDB000398	NADH	MetaboCard
PAMDB000142	Water	MetaboCard

GO Classification:

Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
succinylglutamate-semialdehyde dehydrogenase activity
Process
arginine catabolic process
arginine metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
metabolic process
oxidation reduction

Gene Properties

Locus tag:

PA0898

Strand:

Entrez Gene ID:

883040

Accession:

NP_249589.1

GI:

15596095

Sequence start:

981422

Sequence End:

982888

Sequence Length:

1466

Gene Sequence:

>PA0898
ATGATGAGTACCCATTACATTGCCGGCCAGTGGCTGGCGGGCCAGGGCGAGACCCTGGAGTCCCTCGACCCGGTTGGCCAGGGCGTGGTCTGGTCCGGGCGCGGCGCTGACGCCACCCAGGTCGACGCTGCCGTGTGCGCCGCCCGCGAGGCCTTCCCGGCCTGGGCGCGGCGCCCGCTGGAGCAGCGCATCGAGTTGCTCGAGCGCTTCGCTGCGACCCTCAAGTCCCGCGCCGACGAGCTGGCCCGAGTGATCGGCGAGGAAACCGGCAAGCCGCTGTGGGAGTCGGCCACCGAAGTGACCAGCATGGTCAACAAGGTGGCGATCTCGGTGCAGGCGTTCCGCGAGCGCACCGGCGAGAAATCCGGTCCGCTGGCCGACGCTACCGCCGTGCTACGGCACAAGCCGCATGGCGTGGTGGCGGTATTCGGTCCCTACAATTTCCCCGGCCACCTGCCCAACGGGCATATCGTCCCGGCGCTGCTGGCCGGTAACTGCGTGGTGTTCAAGCCCAGCGAGCTGACCCCGAAGGTCGCCGAGCTGACGCTCAAGGCCTGGATCCAGGCCGGCCTGCCGGCCGGCGTGCTCAACCTGGTCCAGGGCGGTCGCGAAACCGGCGTCGCGCTGGCCGCCCACCGAGGGCTCGACGGTCTGTTCTTCACCGGGTCCAGTCGCACCGGCAACCTGCTGCACAGCCAGTTTGGCGGCCAGCCGCAGAAAATCCTGGCGCTGGAGATGGGCGGCAACAACCCGCTGGTGGTGGAGGAGGTCGCCGACCTCGACGCCGCCGTCTACACCATCATCCAGTCCGCCTTCATCTCCGCAGGCCAGCGTTGCACCTGCGCCCGCCGCCTGCTGGTGCCGCAGGGCGCCTGGGGCGACGCACTGCTGGCGCGCCTGGTGGCGGTCAGCGCTACCCTGCGGGTCGGTCGCTTCGACGAACAGCCGGCGCCGTTCATGGGCGCGGTGATTTCGCTGAGCGCCGCCGAGCACCTGCTCAAGGCCCAGGAGCATTTGATCGGCAAGGGCGCACAGCCGCTGCTGGCGATGACCCAGCCGATCGACGGCGCCGCCCTGCTGACCCCGGGCATCCTCGACGTCAGCGCGGTGGCCGAGCGACCGGACGAAGAGTTCTTCGGGCCGCTGTTGCAAGTGATCCGCTACTCCGATTTCGCTGCGGCGATCCGTGAAGCCAACGCCACCCAGTACGGCCTGGCCGCCGGGTTGCTGTCGGATTCCCGCGAGCGTTTCGAGCAGTTCCTCGTGGAAAGCCGCGCCGGCATCGTCAACTGGAACAAGCAGCTCACCGGCGCCGCCAGCAGCGCGCCGTTCGGCGGTATCGGCGCGTCCGGCAACCACCGGCCGAGCGCCTACTACGCCGCCGATTACTGCGCCTATCCGGTCGCCTCGCTGGAAAGCCCCAGCGTGTCCCTTCCTGCCACCCTGACTCCCGGGATCAGCCTATGA

Protein Properties

Protein Residues:

488

Protein Molecular Weight:

51.5 kDa

Protein Theoretical pI:

6.19

Hydropathicity (GRAVY score):

0.1

Charge at pH 7 (predicted):

-4.73

Protein Sequence:

>PA0898
MMSTHYIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRERTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAMTQPIDGAALLTPGILDVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHRPSAYYAADYCAYPVASLESPSVSLPATLTPGISL

References

External Links:

Resource	Link
Genome ID:	PA0898
Entrez Gene ID:	883040
NCBI Protein ID:	15596095

General Reference:

PaperBLAST - Find papers about PA0898 and its homologs

N-succinylglutamate 5-semialdehyde dehydrogenase (PA0898)