Reaction 21621

Reaction Details
Reaction: Thumb
pyruvate + 2-oxobutanoate + H+ → (S)-2-aceto-2-hydroxybutanoate + CO2
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:ACETOOHBUTSYN-RXN
References:
  • Barak Z, Chipman DM, Gollop N (1987). "Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria." J Bacteriol 169(8);3750-6. PMID: 3301814
  • Bauerle RH, Fruendlich M, Stormer FC, Umbarger HE (1964). "Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium." Biochim Biophys Acta 92;142-9. PMID: 14243762
  • Huseby NE, Christensen TB, Olsen BR, Stormer FC (1971). "The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure." Eur J Biochem 20(2);209-14. PMID: 5560406
  • Stormer FC, Solberg Y, Hovig T (1969). "The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties." Eur J Biochem 10(2);251-60. PMID: 5823101