Reaction Details
Reaction: Thumb
D-threo-isocitrate + NADP+ → 2-oxoglutarate + CO2 + NADPH
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:ISOCITDEH-RXN
References:
  • AGOSIN M, WEINBACH EC (1956). "Partial purification and characterization of the isocitric dehydrogenase from Trypanosoma cruzi." Biochim Biophys Acta 21(1);117-26. PMID: 13363868
  • Camacho ML, Brown RA, Bonete MJ, Danson MJ, Hough DW (1995). "Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence." FEMS Microbiol Lett 134(1);85-90. PMID: 8593959
  • Ceccarelli C, Grodsky NB, Ariyaratne N, Colman RF, Bahnson BJ (2002). "Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism." J Biol Chem 277(45);43454-62. PMID: 12207025
  • DIXON M, MOYLE J (1956). "Purification of the isocitric enzyme (triphosphopyridine nucleotide-linked isocitric dehydrogenase-oxalosuccinic carboxylase)." Biochem J 63(4);548-52. PMID: 13355848
  • Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, Park JW, Park DC, Song BJ, Veech RL, Song H, Huh TL (2004). "Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism." J Biol Chem 279(38);39968-74. PMID: 15254034
  • SIEBERT G, DUBUC J, WARNER RC, PLAUT GW (1957). "The preparation of isocitric dehydrogenase from mammalian heart." J Biol Chem 226(2);965-75. PMID: 13438885
  • Steen IH, Lien T, Birkeland NK (1997). "Biochemical and phylogenetic characterization of isocitrate dehydrogenase from a hyperthermophilic archaeon, Archaeoglobus fulgidus." Arch Microbiol 168(5);412-20. PMID: 9325430
  • Vickery, HB (1962). "A suggested new nomenclature for the isomers of isocitric acid." J Biol Chem 237;1739-41. PMID: 13925783