Delta-aminolevulinic acid dehydratase (PA5243)

Identification
Name: Delta-aminolevulinic acid dehydratase
Synonyms:
  • ALAD
  • ALADH
  • Porphobilinogen synthase
Gene Name: hemB
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
2 Thumb ↔ Thumb+2 Thumb+Thumb
2 5-Aminolevulinic acid ↔ Hydrogen ion + 2 Water + Porphobilinogen
ReactionCard
2 Thumb ↔ Thumb+2 Thumb
2 5-Aminolevulinic acid ↔ Porphobilinogen + 2 Water
ReactionCard
Thumb ↔ Thumb+Thumb+Thumb
5-Aminolevulinic acid ↔ Hydrogen ion + Water + Porphobilinogen
ReactionCard
SMPDB Reactions:
8 Thumb → 4 Thumb+8 Thumb+4 Thumb
8 5-Aminolevulinic acid → 4 Hydrogen ion + 8 Water + 4 Porphobilinogen
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PseudoCyc/BioCyc Reactions:
2 Thumb ↔ Thumb+2 Thumb+Thumb
2 5-Aminolevulinic acid ↔ Hydrogen ion + 2 Water + Porphobilinogen
ReactionCard
Thumb ↔ Thumb+Thumb+Thumb
5-Aminolevulinic acid ↔ Hydrogen ion + Water + Porphobilinogen
ReactionCard
Complex Reactions:
2 Thumb → Thumb+2 Thumb
2 5-Aminolevulinic acid → Porphobilinogen + 2 Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002755-Aminolevulinic acidMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000104PorphobilinogenMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
carbon-oxygen lyase activity
catalytic activity
cation binding
hydro-lyase activity
ion binding
lyase activity
metal ion binding
porphobilinogen synthase activity
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
metabolic process
tetrapyrrole biosynthetic process
Gene Properties
Locus tag: PA5243
Strand: -
Entrez Gene ID: 879701
Accession: NP_253930.1
GI: 15600436
Sequence start: 5904614
Sequence End: 5905627
Sequence Length: 1013
Gene Sequence: 
>PA5243
GTGAGCTTCACTCCCGCCAATCGCGCCTATCCCTACACCCGCCTGCGGCGCAATCGCCGCGATGACTTCTCCCGCCGCCTGGTCCGCGAGAATGTCCTCACCGTCGACGACCTGATCCTGCCGGTGTTCGTCCTCGATGGGGTCAACCAGCGTGAAAGCATTCCGTCGATGCCCGGCGTCGAGCGCCTGTCCATCGACCAGTTGCTGATCGAGGCGGAAGAGTGGGTGGCCCTGGGCATTCCGGCGCTGGCGCTGTTCCCTGTGACCCCGGTGGAGAAGAAGTCCCTGGACGCCGCCGAGGCATACAACCCGGAAGGCATCGCCCAGCGCGCCACCCGTGCCCTGCGCGAGCGCTTTCCGGAGCTGGGCATCATCACCGACGTGGCGCTCGACCCGTTCACCACCCATGGCCAGGACGGCATCCTGGATGACGATGGCTACGTCCTCAACGACGTCAGCATCGACGTGCTGGTACGGCAGGCGCTGTCCCACGCCGAGGCCGGCGCCCAGGTGGTAGCGCCCTCGGACATGATGGACGGTCGCATCGGTGCGATCCGCGAGGCCCTGGAGTCTGCCGGCCACACCAATGTGCGGATCATGGCCTACTCGGCCAAGTACGCCAGCGCCTACTACGGTCCGTTCCGCGATGCGGTCGGCTCGGCTTCGAACCTCGGCAAGGGCAACAAGGCCACCTACCAGATGGATCCGGCGAACAGCGACGAGGCACTTCACGAAGTGGCCGCCGACCTGGCCGAAGGCGCCGACATGGTGATGGTCAAGCCGGGCATGCCCTACCTCGACATCGTGCGTCGGGTGAAGGATGAATTCCGCGCCCCGACCTTTGTCTACCAGGTCAGCGGCGAGTATGCGATGCACATGGGCGCCATCCAGAACGGCTGGCTGGCCGAATCGGTGATCCTCGAATCCCTTACCGCCTTCAAACGTGCCGGCGCCGATGGCATTCTGACCTACTTCGCCAAGCAGGCCGCAGAACAATTAAGACGGGGGCGTTGA
Protein Properties
Protein Residues: 337
Protein Molecular Weight: 37 kDa
Protein Theoretical pI: 4.83
Hydropathicity (GRAVY score): -0.166
Charge at pH 7 (predicted): -9.79
Protein Sequence: 
>PA5243
MSFTPANRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRESIPSMPGVERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAYNPEGIAQRATRALRERFPELGIITDVALDPFTTHGQDGILDDDGYVLNDVSIDVLVRQALSHAEAGAQVVAPSDMMDGRIGAIREALESAGHTNVRIMAYSAKYASAYYGPFRDAVGSASNLGKGNKATYQMDPANSDEALHEVAADLAEGADMVMVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGWLAESVILESLTAFKRAGADGILTYFAKQAAEQLRRGR
References
External Links:
Resource Link
Genome ID: PA5243
Entrez Gene ID: 879701
NCBI Protein ID: 15600436
General Reference: PaperBLAST - Find papers about PA5243 and its homologs