Bifunctional purine biosynthesis protein purH (PA4854)

Identification
Name: Bifunctional purine biosynthesis protein purH
Synonyms:
  • Phosphoribosylaminoimidazolecarboxamide formyltransferase
  • AICAR transformylase
  • IMP cyclohydrolase
  • ATIC
  • IMP synthase
  • Inosinicase
Gene Name: purH
Enzyme Class:
Biological Properties
General Function: Involved in IMP cyclohydrolase activity
Specific Function: 10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb
Water + Inosinic acid ↔ Phosphoribosyl formamidocarboxamide
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Thumb+Thumb ↔ Thumb+Thumb
N10-Formyl-THF + AICAR ↔ Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide
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Thumb+Thumb ↔ Thumb+Thumb
N10-Formyl-THF + AICAR ↔ Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide
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Thumb+Thumb → Thumb+Thumb
N10-Formyl-THF + AICAR → Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide
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SMPDB Reactions:
Tetrahydrofolic acid+Thumb+Thumb → 10-Formyltetrahydrofolate+Thumb+Thumb
Tetrahydrofolic acid + FAICAR + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + AICAR + N10-Formyl-THF
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Thumb+10-Formyltetrahydrofolate+Thumb → Thumb+Thumb
AICAR + 10-Formyltetrahydrofolate + N10-Formyl-THF → FAICAR + tetrahydropteroyl mono-L-glutamate
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Thumb ↔ Thumb+Thumb
FAICAR ↔ Inosinic acid + Water
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb
Water + Inosinic acid ↔ Phosphoribosyl formamidocarboxamide
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Thumb+Thumb ↔ Thumb+Thumb
N10-Formyl-THF + AICAR ↔ Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide
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Thumb+Thumb → Thumb+Thumb
N10-Formyl-THF + AICAR → Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide
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Complex Reactions:
Thumb+Thumb ↔ Thumb+Thumb
N10-Formyl-THF + Phosphoribosyl formamidocarboxamide ↔ Phosphoribosyl formamidocarboxamide + Tetrahydrofolic acid
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Thumb+Thumb → Thumb
Inosinic acid + Water → Phosphoribosyl formamidocarboxamide
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000407AICARMetaboCard
PAMDB006305FAICARMetaboCard
PAMDB000601Inosinic acidMetaboCard
PAMDB000213N10-Formyl-THFMetaboCard
PAMDB000388Phosphoribosyl formamidocarboxamideMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB006378tetrahydropteroyl mono-L-glutamateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
cyclohydrolase activity
glycine hydroxymethyltransferase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
hydroxymethyl-, formyl- and related transferase activity
IMP cyclohydrolase activity
methyltransferase activity
phosphoribosylaminoimidazolecarboxamide formyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA4854
Strand: +
Entrez Gene ID: 880046
Accession: NP_253541.1
GI: 15600047
Sequence start: 5449046
Sequence End: 5450653
Sequence Length: 1607
Gene Sequence: 
>PA4854
ATGACCGACCAAACCACCCGCCTGCCCATCCGCCGCGCGCTGATCAGCGTTTCCGACAAGACCGGCGTCGTCGACTTCGCCCGTGAGCTGGTCGCCCTCGGCGTGGAAATCCTTTCCACCGGCGGCACCTACAAGCTGCTCCGGGACAACGGCATCTCTGCCGTGGAAGTGGCCGACTACACCGGCTTCCCGGAAATGATGGACGGTCGGGTGAAGACCCTGCACCCGAAGGTGCATGGCGGTATCCTCGGTCGCCGCGACCTGGACGGCGCGGTCATGGAGCAGCACGGCATCAAGCCGATCGACCTGGTGGCGGTCAACCTGTATCCCTTCGAGGCCACGGTGGCCAGGCCCGACTGCGACCTGCCTACCGCCATCGAGAACATCGATATCGGCGGGCCGACCATGGTCCGTTCGGCGGCGAAGAACCACAAGGATGTCGCCATCGTGGTCAATGCCGGCGACTACGCCGCCGTGATCGAATCCCTCAAGGCCGGCGGCCTGACCTACGCCCAGCGTTTCGACCTGGCCCTCAAGGCGTTCGAGCACACCTCCGCCTACGACGGCATGATCGCCAACTACCTGGGTACCATCGACCAGACCCGCGATACCCTAGGCACCGCCGACCGCGGCGCCTTCCCGCGCACCTTCAACAGTCAGTTCGTCAAGGCCCAGGAAATGCGCTACGGCGAGAACCCGCACCAGAGCGCGGCGTTCTACGTCGAGGCGAAGAAGGGCGAGGCCAGCGTCTCCACCGCCATCCAGTTGCAGGGCAAGGAACTGTCGTTCAACAACGTCGCCGACACCGACGCCGCCCTGGAATGCGTGAAGAGCTTCCTCAAGCCGGCCTGCGTGATCGTCAAGCATGCCAACCCCTGCGGCGTCGCCGTGGTGCCGGAAGACGAAGGCGGCATCCGCAAGGCCTACGACCTGGCCTACGCCACCGATAGCGAATCGGCGTTCGGCGGCATCATCGCCTTCAACCGCGAGCTGGACGGCGAAACCGCCAAGGCCATCGTCGAGCGCCAGTTCGTCGAGGTGATCATCGCGCCGAAGATTTCCGCCGCCGCCCGCGAGGTGGTCGCCGCCAAGGCCAACGTACGCCTGCTCGAATGCGGCGAATGGCCAGCCGAGCGCGCCCCGGGCTGGGACTTCAAGCGGGTCAACGGCGGCCTGCTGGTACAGAGCCGCGACATCGGCATGATCAAGGCCGAGGACCTGAAGATCGTCACTCGCCGCGCGCCCACCGAGCAGGAGATCCACGACCTGATCTTCGCCTGGAAGGTGGCCAAGTTCGTCAAGTCCAACGCCATCGTCTACGCCAGGAACCGCCAGACCGTCGGCGTCGGCGCCGGCCAGATGAGCCGGGTCAACTCCGCACGGATCGCCGCGATCAAGGCCGAGCACGCCGGCCTGGAAGTGAAAGGCGCGGTGATGGCTTCCGACGCCTTCTTCCCGTTCCGCGACGGCATCGACAACGCGGCCAAGGCCGGCATCACCGCGGTGATCCAGCCGGGCGGCTCGATGCGCGACAACGAAGTGATCGCGGCGGCCGACGAGGCGGATATCGCGATGGTGTTCACTGGCATGCGCCATTTCCGCCATTGA
Protein Properties
Protein Residues: 535
Protein Molecular Weight: 57.7 kDa
Protein Theoretical pI: 6.45
Hydropathicity (GRAVY score): -0.068
Charge at pH 7 (predicted): -3.48
Protein Sequence: 
>PA4854
MTDQTTRLPIRRALISVSDKTGVVDFARELVALGVEILSTGGTYKLLRDNGISAVEVADYTGFPEMMDGRVKTLHPKVHGGILGRRDLDGAVMEQHGIKPIDLVAVNLYPFEATVARPDCDLPTAIENIDIGGPTMVRSAAKNHKDVAIVVNAGDYAAVIESLKAGGLTYAQRFDLALKAFEHTSAYDGMIANYLGTIDQTRDTLGTADRGAFPRTFNSQFVKAQEMRYGENPHQSAAFYVEAKKGEASVSTAIQLQGKELSFNNVADTDAALECVKSFLKPACVIVKHANPCGVAVVPEDEGGIRKAYDLAYATDSESAFGGIIAFNRELDGETAKAIVERQFVEVIIAPKISAAAREVVAAKANVRLLECGEWPAERAPGWDFKRVNGGLLVQSRDIGMIKAEDLKIVTRRAPTEQEIHDLIFAWKVAKFVKSNAIVYARNRQTVGVGAGQMSRVNSARIAAIKAEHAGLEVKGAVMASDAFFPFRDGIDNAAKAGITAVIQPGGSMRDNEVIAAADEADIAMVFTGMRHFRH
References
External Links:
Resource Link
Genome ID: PA4854
Entrez Gene ID: 880046
NCBI Protein ID: 15600047
General Reference: PaperBLAST - Find papers about PA4854 and its homologs