Peptidyl-tRNA hydrolase (PA4672)

Identification
Name: Peptidyl-tRNA hydrolase
Synonyms:
  • PTH
Gene Name: pth
Enzyme Class:
Biological Properties
General Function: Involved in aminoacyl-tRNA hydrolase activity
Specific Function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death
Cellular Location: Cytoplasm
KEGG Pathways: Not Available
KEGG Reactions:
N-Substituted aminoacyl-tRNA+Thumb ↔ N-Substituted amino acid+tRNA
N-Substituted aminoacyl-tRNA + Water ↔ N-Substituted amino acid + tRNA
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
N-substituted aminoacyl-tRNA+Thumb → N-substituted amino acid+tRNA
N-substituted aminoacyl-tRNA + Water → N-substituted amino acid + tRNA
ReactionCard
Thumb
an N-modified aminoacyl-[tRNA] + H2O → an uncharged tRNA + an N-modified amino acid + 2 H+
ReactionCard
PAMDB000142 → PAMDB000069+PAMDB001633
Water → L-Asparagine + Hydrogen ion
ReactionCard
Complex Reactions:
N-substituted aminoacyl-tRNA+Thumb → N-substituted amino acid+tRNA
N-substituted aminoacyl-tRNA + Water → N-substituted amino acid + tRNA
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000142WaterMetaboCard
GO Classification:
Function
aminoacyl-tRNA hydrolase activity
carboxylesterase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
Process
biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
metabolic process
translation
Gene Properties
Locus tag: PA4672
Strand: +
Entrez Gene ID: 881396
Accession: NP_253361.1
GI: 15599867
Sequence start: 5240122
Sequence End: 5240706
Sequence Length: 584
Gene Sequence: 
>PA4672
GTGACTGCCGTACAACTGATCGTTGGCCTGGGAAACCCGGGTCCTGAATACGACCAGACCCGGCATAACGCGGGGGCCCTTTTCGTTGAGCGCCTGGCGCATGCCCAGGGCGTCAGCCTCGTGGCTGACCGCAAGTATTTCGGCCTGGTCGGCAAGTTCAGCCACCAGGGCAAGGACGTTCGTCTGTTGATCCCGACCACCTACATGAACCGCAGCGGCCAGTCCGTGGCGGCGCTGGCGGGATTCTTCCGGATCGCCCCGGACGCCATCCTGGTGGCCCACGACGAACTCGACATGCCCCCTGGCGTCGCCAAGCTCAAGACCGGCGGCGGACACGGCGGGCACAACGGGTTGCGCGACATCATCGCCCAGCTCGGCAATCAGAATTCTTTCCATCGCCTGCGGCTTGGCATCGGCCATCCGGGGCACAGCAGCCTGGTTTCCGGTTACGTGCTCGGCCGCGCCCCGCGCAGCGAGCAGGAACTGCTCGACACCAGCATCGACTTCGCCCTCGGCGTGCTGCCGGAAATGCTCGCCGGGGACTGGACCCGGGCGATGCAGAAGCTGCACAGCCAGAAGGCCTGA
Protein Properties
Protein Residues: 194
Protein Molecular Weight: 20.8 kDa
Protein Theoretical pI: 9.82
Hydropathicity (GRAVY score): -0.114
Charge at pH 7 (predicted): 5.39
Protein Sequence: 
>PA4672
MTAVQLIVGLGNPGPEYDQTRHNAGALFVERLAHAQGVSLVADRKYFGLVGKFSHQGKDVRLLIPTTYMNRSGQSVAALAGFFRIAPDAILVAHDELDMPPGVAKLKTGGGHGGHNGLRDIIAQLGNQNSFHRLRLGIGHPGHSSLVSGYVLGRAPRSEQELLDTSIDFALGVLPEMLAGDWTRAMQKLHSQKA
References
External Links:
Resource Link
Genome ID: PA4672
Entrez Gene ID: 881396
NCBI Protein ID: 15599867
General Reference: PaperBLAST - Find papers about PA4672 and its homologs