| Identification |
| Name: |
Glutamyl-tRNA reductase |
| Synonyms: |
|
| Gene Name: |
hemA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in glutamyl-tRNA reductase activity |
| Specific Function: |
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA). In the absence of NADPH, exhibits substrate esterase activity, leading to the release of glutamate from tRNA |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
L-Glutamyl-tRNA(Glu) | + |  | + |  | + | tRNA(Glu) | ↔ |  | + | tRNA(Glu) | + |  | + |  |
| |
|
| SMPDB Reactions: |
|
8 L-glutamyl-tRNA(Glu) | + | 8 NADPH | + | 8 | → | 8 tRNA(Glu) | + | 8 | + | 8 |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
L-Glutamyl-tRNA(Glu) | + | | + | | → | | + | | + | tRNA (Glu) |
| | |
| + | | + | tRNA(Glu) | → | L-glutamyl-tRNA(Glu) | + | |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| binding | | catalytic activity | | glutamyl-tRNA reductase activity | | NADP or NADPH binding | | nucleotide binding | | oxidoreductase activity | | oxidoreductase activity, acting on CH-OH group of donors | | oxidoreductase activity, acting on the aldehyde or oxo group of donors | | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | | shikimate 5-dehydrogenase activity | | Process |
|---|
| biosynthetic process | | cellular biosynthetic process | | heterocycle biosynthetic process | | metabolic process | | oxidation reduction | | tetrapyrrole biosynthetic process |
|
| Gene Properties |
| Locus tag: |
PA4666 |
| Strand: |
- |
| Entrez Gene ID: |
881361 |
| Accession: |
NP_253355.1 |
| GI: |
15599861 |
| Sequence start: |
5233585 |
| Sequence End: |
5234853 |
| Sequence Length: |
1268 |
| Gene Sequence: |
>PA4666
ATGGCCTTCATTGCCCTCGGCATCAATCACAAGACCGCCTCGGTGGCTGTCCGCGAGCGCGTGGCTTTCACTCCGGAACAGATGGTCGAGGCGCTGCAGCAGCTCTGCCGCCTGACCACCAGCCGCGAGGCGGCCATCCTGTCGACCTGCAACCGGAGCGAACTCTACCTGGAGATCGACCATCCGACCGCGGACGACGTGCTCGCCTGGCTGGCGGACTACCATCGCCTGACTCTCGACGAGTTGCGCGCCTGTGCCTATGTGCACCAGGACGAAGACGCGGTGCGCCACATGATGCGCGTGGCCTCCGGCCTCGACTCGATGGTCCTCGGCGAGCCGCAGATCCTCGGCCAGATGAAGTCGGCCTACGCCGTCGCGCGCGAGGCCGGCACCGTCGGTCCGCTGCTCGGCCGCCTGTTCCAGGCCACCTTCAGTACGGCGAAGACCGTCCGCACCGATACCGCCATCGGCGAGAACCCGGTGTCCGTGGCGTTCGCCGCGGTGAGCCTGGCCAAGCAGATCTTCAGCGACCTGCACCGCAGCCAGGCGCTGCTGATCGGCGCCGGCGAGACCATCACCCTGGTCGCGCGCCACCTGTTCGAGCAAGGCGTGAAGCGCATCGTGGTGGCCAACCGCACCCTGGAGCGCGCCAGCCTGCTCGCCGAGCAGTTCGGCGCCCATGCGGTGCTGCTTTCGGAGATCCCCGAGGAGTTGGCCAACAGCGATATCGTCATCAGCTCCACTGCCAGCCAGTTGCCGATCCTCGGCAAGGGCGCCGTGGAGCGCGCGCTGAAGCAGCGCAAGCACAAGCCGATGTTCATGGTCGACATCGCCGTGCCGCGCGACATCGAGCCGGAAGTCGGCGAACTGGACGACGTCTACCTCTATAGCGTCGACGACCTCCACGAAGTAGTGGCGGAGAATCTCAAGAGCCGCCAGGGCGCTGCCCAGGCCGCCGAGGAACTGGTCGGCAGCGGCGTCGCCGAGTTCATGCAGCGCCTGCGCGAACTGGCCGCGGTGGACGTGCTGCGCGCCTATCGGCAGCAGGCCGAGCGCCTGCGCGATGAGGAGCTGGGCAAGGCCCAGCGGCAACTGGCCAACGGTGCCGACCCCGCCGAGGTGATGGCCCAGCTGGCCCGCGGCCTGACCAACAAACTGCTGCACGCGCCCAGCGTGCAGATGAAGAAAATGTCCGCCGAGGGCCGCATCGACGCGCTGGCCCTGGCCCAGGAGCTGTTCGCCCTCGACGAGGGCGCGCCGCGCCACTGA |
| Protein Properties |
| Protein Residues: |
422 |
| Protein Molecular Weight: |
46.1 kDa |
| Protein Theoretical pI: |
5.63 |
| Hydropathicity (GRAVY score): |
-0.042 |
| Charge at pH 7 (predicted): |
-9.18 |
| Protein Sequence: |
>PA4666
MAFIALGINHKTASVAVRERVAFTPEQMVEALQQLCRLTTSREAAILSTCNRSELYLEIDHPTADDVLAWLADYHRLTLDELRACAYVHQDEDAVRHMMRVASGLDSMVLGEPQILGQMKSAYAVAREAGTVGPLLGRLFQATFSTAKTVRTDTAIGENPVSVAFAAVSLAKQIFSDLHRSQALLIGAGETITLVARHLFEQGVKRIVVANRTLERASLLAEQFGAHAVLLSEIPEELANSDIVISSTASQLPILGKGAVERALKQRKHKPMFMVDIAVPRDIEPEVGELDDVYLYSVDDLHEVVAENLKSRQGAAQAAEELVGSGVAEFMQRLRELAAVDVLRAYRQQAERLRDEELGKAQRQLANGADPAEVMAQLARGLTNKLLHAPSVQMKKMSAEGRIDALALAQELFALDEGAPRH |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA4666 and its homologs
|
