P. aeruginosa Metabolome Database Protein PA4225

Identification

Name:

pyochelin synthetase

Synonyms:

Not Available

Gene Name:

pchF

Enzyme Class:

Not Available

Biological Properties

General Function:

transport, pyochelin biosynthetic process, metabolic process, biosynthetic process

Specific Function:

hydrolase activity, acting on ester bonds, catalytic activity

Cellular Location:

Not Available

KEGG Pathways:

pyochelin biosynthesis PWY-6408

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

a [PchF protein]-N-desmethyl-pyochelin + S-adenosyl-L-methionine → a PchF NRPS protein loaded with pyochelin + S-adenosyl-L-homocysteine + H⁺
ReactionCard

cysteine-adenylate + PchF NRPS → a PchF NRPS protein loaded with L-cysteine + AMP
ReactionCard

a PchF NRPS protein loaded with pyochelin + H₂O → pyochelin + PchF NRPS + H⁺
ReactionCard

→

salicylate + L-Cysteine + S-Adenosylmethionine + NADPH → pyochelin + S-Adenosylhomocysteine + NADP⁺ + Water
ReactionCard

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

Not Available

GO Classification:

Function
hydrolase activity, acting on ester bonds
catalytic activity
Process
transport
pyochelin biosynthetic process
metabolic process
biosynthetic process

Gene Properties

Locus tag:

PA4225

Strand:

Entrez Gene ID:

880083

Accession:

NP_252915.1

GI:

15599421

Sequence start:

4731369

Sequence End:

4736798

Sequence Length:

5429

Gene Sequence:

>PA4225
ATGAGCCTCGGCGAACTGCTGGAAACCTGCCGCAGCCGGCGCATCGAACTCTGGAGCGAGGCGGGCCGCCTGCGCTATCGCGCCCCCCAGGGTGCCCTCGACGCCGGCCTCGCCGAGCGCCTGCGGGCCGAGCGCGAGGCCCTGCTGGAACACCTGGAAGGCGGCCCTGGCTGGCGCGCCGAACCCGACATGGCCCACCAGCGCTTCCCGCTGACCCCGGTGCAGGCCGCCTACGTGCTGGGCCGCCAGGCGGCCTTCGACTACGGCGGTAACGCCTGCCAGCTGTACGCCGAGTACGACTGGCCGGCCGACACCGATCCGGCGCGCCTGGAGGCGGCCTGGAACGCCATGGTCGAGCGCCACCCGATGCTGCGCGCGGTGATCGAGGACAACGCCTGGCAGCGCGTGCTGCCCGAGGTGCCCTGGCAGCGGCTGACCGTGCATGCCTGCGCGGGGCTCGACGAGGCCGCTTTCCAGGCGCACCTGGAGCGGGTCCGCGAACGCCTCGACCACGCCTGCGCGGCGCTCGACCAGTGGCCGGTCCTGCGCCCCGAGCTGAGTATCGGCCGGGATGCCTGCGTACTGCACTGCTCGGTGGATTTCACCCTGGTCGACTACGCCAGCCTGCAATTGCTGCTTGGCGAATGGCGCCGCCGCTATCTCGATCCGCAATGGACGGCGGAACCGCTGGAGGCGACCTTCCGCGACTATGTCGGCGTCGAGCAGCGCCGACGCCAGTCGCCAGCCTGGCAGCGCGACCGCGACTGGTGGCTGGCGCGTCTCGACGCGCTACCGGGGCGTCCCGACCTGCCGCTGCGGGTGCAGCCGGACACCCGGTCCACGCGCTTCCGGCACTTCCACGCGCGCCTCGACGAGGCCGCCTGGCAGGCGCTCGGCGCGCGCGCCGGCGAACACGGCCTGAGCGCTGCCGGCGTGGCCTTGGCGGCCTTCGCCGAGACCATCGGTCGCTGGAGCCAGGCACCGGCGTTCTGTCTCAACCTGACGGTACTCAACCGGCCGCCGCTGCATCCGCAGCTGGCGCAGGTGCTCGGTGACTTCACCGCGCTCAGCCTGCTGGCAGTGGACAGCCGCCACGGCGACAGTTTCGTCGAGCGTGCCCGACGCATCGGCGAGCAGATGTTCGACGACCTCGACCACCCGACCTTCAGCGGCGTCGACCTGCTGCGCGAACTGGCGCGCCGGCGTGGTCGCGGCGCCGATCTGATGCCGGTGGTGTTCACCAGTGGCATCGGCAGCGTGCAGCGCCTGCTCGGCGATGGCGAGGCGCCGCGCGCGCCACGCTACATGATCAGCCAGACCCCGCAGGTCTGGCTGGACTGCCAGGTCACCGACCAGTTCGGCGGCCTGGAGATCGGCTGGGACGTACGCCTCGGGTTGTTCCCCGAGGGCCAGGCGGAAGCCATGTTCGACGACTTCGTCGGGCTGCTCCGGCGCCTGGCGCAGAGCCCGCGCGCCTGGACCGACGGCGATGCCACGGAACCCGTCGAGGCGCCGCCGCAGGCGTTGCCCGGTAGTGCCCGGAGCATCGCCGCCGGTTTCGCCGAGCGTGCCCTGCTGACCCCCGACGCCACGGCGATCCACGATGCCGCCGGCAGCTACAGCTACCGCCAGGTCGCCCAGCACGCCAGCGCCCTGCGCCGCGTCCTGGAAGCGCACGGCGCGGGCCGTGGCCGGCGGGTCGCGGTGATGCTGCCGAAAAGCGCCGCGCAATTGGTCGCGGTGATCGGCATCCTCCAGGCCGGCGCCGCCTATGTGCCGGTGGACATCCGCCAGCCTCCGCTGCGGCGCCAGGCGATCCTCGCCAGCGCCGAAGTGGTCGCGCTGGTCTGCCTGGAAAGCGATGTCCCGGACGTCGGCTGCGCCTGCGTGGCCATCGACCGGCTGGCCGCCGACAGCGCCTGGCCGCCACCGCCCGCGGCGGAGGTGGCGGCGGACGACCTCGCCTACGTGATCTACACCTCCGGCTCCACCGGCACGCCAAAGGGCGTGATGCTCAGCCATGCGGCGGTGAGCAACACGCTGCTCGACATCAACCAGCGCTACGGCGTCGACGCCAACGACCGCGTCCTCGGCCTCGCCGAGCTGAGCTTCGACCTCTCGGTCTACGACTTCTTCGGCGCCACCGCGGCGGGGGCCCAGGTGGTCCTCCCGGACCCGGCGCGCGGCAGCGATCCATCGCACTGGGCGGAACTGCTGGAACGCCACGCCATCACCCTGTGGAACTCGGTGCCGGCCCAAGGCCAGATGCTCATCGATTACCTGGAGAGCGAGCCGCAACGTCACCTGCCGGGACCGCGCTGCGTGCTCTGGTCCGGTGACTGGATTCCGGTCAGCCTGCCGACCCGCTGGTGGCGGCGCTGGCCGGACAGCGCGCTGTTCAGCCTGGGCGGCGCCACCGAGGCGGCGATCTGGTCGATCGAGCAGCCGATCCGCCCGCAGCACACCGAGCTGGCCAGCATCCCTTATGGCCGTGCCCTGCGCGGGCAGAGCGTGGAAGTCCTGGATGCCCGCGGGCGGCGCTGCCCGCCGGGCGTGCGCGGCGAGATCCATATCGGCGGGGTGGGCCTGGCGCTCGGCTACGCCGGCGATCCGCAGCGCACCGCCGAACGCTTCGTCCGTCACCCCGATGGCCGTCGCCTGTATCGCACCGGCGACCTCGGCCGCTACCTGGCCGACGGCAGCATCGAGTTCCTCGGCCGCGAGGACGACCAGGTGAAGATTCGCGGCCACCGCATCGAACTGGCCGAACTGGACGCCGCGCTGTGCGCTCATCCGCAGGTCAACCTGGCGGCCACCGTGGTGCTCGGCGAGACCCACGAGCGCAGCCTGGCCAGCTTCGTCACCCTGCATGCGCCGGTGGAGGCTGGCGAGGATCCGCGTACGGCGCTCGACGCGGTGCGCCAGCGGGCGGCCCAGGCCTTGCGCCGCGACTGGGGCAGCGAGGAGGGCATCGCCGCGGCGGTGGCCGCACTCGACCGTGCCTGCCTCGCCTCGTTGGCCGCCTGGCTGGCCGGCAGCGGTCTGTTCGCCAGTGCGACGCCGCTGGACTTAGCCACCCTGTGCCAGCGCCTGGGTATCGCCGAGGCGCGCCAGCGCCTGCTGCGCCACTGGTTGCGCCAACTGGAGGAGGGCGGCTACCTGCGCGCCGAGGGCGAGGGCTGGCTGGGCTGCGCCGAGCGTCCCGCGCAGAGTCCGGAGGACGCCTGGACGGCGTTCGCCGGCTGCGCGCCGGCGGCGCTCTGGCCGGCCGAGCTGGTCGCCTACCTGCGTGACAGCGCGCAATCCCTCGGCGAGCAACTGGCCGGGCGGATCAGCCCGGCGGCGCTGATGTTCCCGCAGGGCTCGGCGCGCATCGCCGAGGCCATGTACAGCCAGGGCCTGCATGCCCAGGCGCTGCACGAGGCCATGGCCGAGGCCATCGCCGCCATCGTCGAGCGCCAGCCGCAACGGCGCTGGCGCCTGCTGGAGCTTGGCGCCGGCACCGCCGCCGCCAGCCGCACGGTGATCGCCCGGTTGGCGCCGCTGGTGCAGCGAGGGGCGGAGGTGGACTACCTGTTCACCGACGTTTCCAGCTACTTCCTCGCCGCCGCCCGCGAGCGCTTCGCCGACCAGCCGTGGGTACGCTTCGGCCGCTTCGACATGAACGGCGATCTTCTCGACCAGGGCGTGGCGCCGCACTCGGTGGATATCCTGCTCAGCTCCGGGGCCTTGAACAACGCGCTGGACACCCCGGCGCTGCTGGCCGGCCTGCGCGAGTTGCTGAGCGCCGACGCCTGGCTGGTGATCCAGGAACTGACGCGCGAGCACAACGAGATCAGCGTCAGCCAGAGCCTGATGATGGAAAACCCGCGCGACCTCCGCGACGAGCGCCGCCAACTGTTCGTCCACACCGGGCAATGGCTGGAGTGGCTGGCGGCACAGGGTGGCGACCTGGCTTGTGGGGTGGTGCCGCCGGGCAGCGCTCTCGACCTGCTTGGCTACGATGTCCTGCTGGCTCGCTGCAAGACCGACCGCGCCCGCCTGGAGCCGGCCGAGCTGCTGGCCTTCGTCGAAGCGCGGGTGCCGCGCTACATGCTCCCGGCGCAGTTGCGCGTGCTCGAACGCCTGCCGGTCACCGGCAACGGCAAGATCGACCGCAAGGCCCTGACCGGCTTTGCCCGCCAGCCCCAGGCGGACCTTCGGCATGGCGTCGCGCAGGCACCGGCCGACGAACTGGAGAATGCGCTGCTGGCACTCTGGCGGGAGGTGCTGGACAACCCGTCGCTGGGCGTCGAGCAAGACTTCTTCGGGGCCGGCGGCGACTCGCTGTTGATCGCCCAGTTGATCGCCCGTTTGCGCGAACGACTGGAAAGCGCCCGTCGGCATCCGTTCGATCGCCTGCTACGCTGGGCGCTCAGCCAGCCGACGCCGCGCGGCCTGGCCGAACGCCTGCGCAGCGCGCCGGAAGAGGGCCGTGGGCCAGCCCTGGCCGCGGCGCGCGGCGTCGCCCCGGCGCCGGCCGGCATGTCGCGCGCACCGCTCGCCGAGGGCGCGGTGGCGCTCGACCCGCTGGTGCGCCTGGTGCCCGGCGAGGGCGTGCCGCGGGTGCTGGTCCACGAAGGCCTCGGCACGCTACTGCCGTACCGCCCGCTGCTTCGCGCCCTGGGTGAGGGGCGGCCGTTGCTGGGGCTGGCCGTGCATGACAGCGACGCCTACCTGGCGATCCCCGCCGAGCATCTCAACGCCTGCCTCGGCCGCCGCTACGCCGAGGCGCTCCATCGCGCCGGGCTACGCGAGGTCGACCTGCTCGGCTACTGCTCCGGCGGGCTGGTCGCCCTGGAGACCGCCAAGTCCCTGGTCCAGCGCGGGGTGCGCGTGCGCCAACTGGATATCGTCTCCAGCTACCGGATTCCCTACCGGGTGGACGACGAGCGCCTGCTGTTGTTCAGCTTCGCCGCGACCCTCGGCCTGGATACCGCGGCGCTCGGCTTCCCCGCGCCGGAACGTCTCGGCCAGGCGGTGCAGGCGGCGCTCGCGCAGACACCGGAGCGCCTGGTCGCCGAGGCGCTGGCGGGGCTGCCGGGCCTGGCCGATCTCGTCGCCCTGCGCGGCCGCGTGCTACAGGCGGCCAGCGGTAGCGCCGACGCCGTCAGCGTCGAACGCGACACCCTCTACCGGCTGTTCTGTCACTCGGTGCGTGCCAGCCAGGCCGAGGCGCCGGAGCCCTACGTCGGCGCGCTGCGGCTGTTCGTGCCGGACGCCGGCAACCCATTGGTGCCGCGCTACGCCGAGGCTCTGGAGACCCAATGGCGGGCCGCCGCGCTTGGCGCGTGCGGCATCCACGAGGTGCCCGGCGGGCACTTCGACTGCCTGGGCGAAGCCCTGGCGCAATCCTTGTCGAAACCCATGCCAGAGGAGGCGAGCCGATGA

Protein Properties

Protein Residues:

1809

Protein Molecular Weight:

197.1 kDa

Protein Theoretical pI:

5.87

Hydropathicity (GRAVY score):

-0.112

Charge at pH 7 (predicted):

-27.5

Protein Sequence:

>PA4225
MSLGELLETCRSRRIELWSEAGRLRYRAPQGALDAGLAERLRAEREALLEHLEGGPGWRAEPDMAHQRFPLTPVQAAYVLGRQAAFDYGGNACQLYAEYDWPADTDPARLEAAWNAMVERHPMLRAVIEDNAWQRVLPEVPWQRLTVHACAGLDEAAFQAHLERVRERLDHACAALDQWPVLRPELSIGRDACVLHCSVDFTLVDYASLQLLLGEWRRRYLDPQWTAEPLEATFRDYVGVEQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRVQPDTRSTRFRHFHARLDEAAWQALGARAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRPPLHPQLAQVLGDFTALSLLAVDSRHGDSFVERARRIGEQMFDDLDHPTFSGVDLLRELARRRGRGADLMPVVFTSGIGSVQRLLGDGEAPRAPRYMISQTPQVWLDCQVTDQFGGLEIGWDVRLGLFPEGQAEAMFDDFVGLLRRLAQSPRAWTDGDATEPVEAPPQALPGSARSIAAGFAERALLTPDATAIHDAAGSYSYRQVAQHASALRRVLEAHGAGRGRRVAVMLPKSAAQLVAVIGILQAGAAYVPVDIRQPPLRRQAILASAEVVALVCLESDVPDVGCACVAIDRLAADSAWPPPPAAEVAADDLAYVIYTSGSTGTPKGVMLSHAAVSNTLLDINQRYGVDANDRVLGLAELSFDLSVYDFFGATAAGAQVVLPDPARGSDPSHWAELLERHAITLWNSVPAQGQMLIDYLESEPQRHLPGPRCVLWSGDWIPVSLPTRWWRRWPDSALFSLGGATEAAIWSIEQPIRPQHTELASIPYGRALRGQSVEVLDARGRRCPPGVRGEIHIGGVGLALGYAGDPQRTAERFVRHPDGRRLYRTGDLGRYLADGSIEFLGREDDQVKIRGHRIELAELDAALCAHPQVNLAATVVLGETHERSLASFVTLHAPVEAGEDPRTALDAVRQRAAQALRRDWGSEEGIAAAVAALDRACLASLAAWLAGSGLFASATPLDLATLCQRLGIAEARQRLLRHWLRQLEEGGYLRAEGEGWLGCAERPAQSPEDAWTAFAGCAPAALWPAELVAYLRDSAQSLGEQLAGRISPAALMFPQGSARIAEAMYSQGLHAQALHEAMAEAIAAIVERQPQRRWRLLELGAGTAAASRTVIARLAPLVQRGAEVDYLFTDVSSYFLAAARERFADQPWVRFGRFDMNGDLLDQGVAPHSVDILLSSGALNNALDTPALLAGLRELLSADAWLVIQELTREHNEISVSQSLMMENPRDLRDERRQLFVHTGQWLEWLAAQGGDLACGVVPPGSALDLLGYDVLLARCKTDRARLEPAELLAFVEARVPRYMLPAQLRVLERLPVTGNGKIDRKALTGFARQPQADLRHGVAQAPADELENALLALWREVLDNPSLGVEQDFFGAGGDSLLIAQLIARLRERLESARRHPFDRLLRWALSQPTPRGLAERLRSAPEEGRGPALAAARGVAPAPAGMSRAPLAEGAVALDPLVRLVPGEGVPRVLVHEGLGTLLPYRPLLRALGEGRPLLGLAVHDSDAYLAIPAEHLNACLGRRYAEALHRAGLREVDLLGYCSGGLVALETAKSLVQRGVRVRQLDIVSSYRIPYRVDDERLLLFSFAATLGLDTAALGFPAPERLGQAVQAALAQTPERLVAEALAGLPGLADLVALRGRVLQAASGSADAVSVERDTLYRLFCHSVRASQAEAPEPYVGALRLFVPDAGNPLVPRYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQSLSKPMPEEASR

References

External Links:

Resource	Link
Genome ID:	PA4225
Entrez Gene ID:	880083
NCBI Protein ID:	15599421

General Reference:

PaperBLAST - Find papers about PA4225 and its homologs

pyochelin synthetase (PA4225)