2-keto-3-deoxy-L-rhamnonate aldolase (PA4128)

Identification
Name: 2-keto-3-deoxy-L-rhamnonate aldolase
Synonyms:
  • KDR aldolase
  • 2-dehydro-3-deoxyrhamnonate aldolase
  • 2-keto-3-deoxy acid sugar aldolase
Gene Name: rhmA
Enzyme Class:
Biological Properties
General Function: Involved in carbon-carbon lyase activity
Specific Function: Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3- deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate
Cellular Location: Not Available
KEGG Pathways:
  • Fructose and mannose metabolism pae00051
  • Microbial metabolism in diverse environments pae01120
KEGG Reactions:
Thumb ↔ Thumb+Thumb+Thumb
2-Dehydro-3-deoxy-L-rhamnonate ↔ Lactaldehyde + Pyruvic acid + (S)-Lactaldehyde
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb+Thumb
2-Dehydro-3-deoxy-L-rhamnonate ↔ Lactaldehyde + Pyruvic acid + (S)-Lactaldehyde
ReactionCard
Thumb → Thumb+Thumb
2-Dehydro-3-deoxy-L-rhamnonate → Pyruvic acid + D-Lactaldehyde
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
2-Dehydro-3-deoxy-L-rhamnonate → Pyruvic acid + D-Lactaldehyde
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB004860(S)-LactaldehydeMetaboCard
PAMDB0020382-Dehydro-3-deoxy-L-rhamnonateMetaboCard
PAMDB000673D-LactaldehydeMetaboCard
PAMDB000476LactaldehydeMetaboCard
PAMDB000102Pyruvic acidMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
catalytic activity
lyase activity
Process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
Gene Properties
Locus tag: PA4128
Strand: +
Entrez Gene ID: 881843
Accession: NP_252817.1
GI: 15599323
Sequence start: 4616162
Sequence End: 4616968
Sequence Length: 806
Gene Sequence: 
>PA4128
ATGGACCTGCCCGTCAATCGCTTCAAGCAACGCCTGCGCAGCGGCGAGGCGCAGATCGGCCTGTGGCTCGGCCTGGCCGATCCCTACTGCGCGGAGCTGGCCGCCAACGCCGGCTTCGACTGGCTGCTGCTGGACGGCGAGCACGCGCCCAACGACCTGCGCAGCCTGCTCGGCCAGTTGCAGGCGCTGGCGCCCTACCCCGGCCAGCCGGTGATCCGCCCGGTGCAGGGCGACACTGCGCTGATCAAGCAATTGCTCGACATCGGCGCGCAGACCCTGCTGGTACCGATGGTCGACAGCGCCGCCCAGGCCGAAGGGCTGGTGCGCGCCGTGCGCTATCCGCCGGCGGGCGTACGCGGGGTCGGCAGTGCGCTGGCCCGGGCCTCGCGCTGGAACAGCGTGGCGGAGTACCTGAACCACGCCGACGAGCAGATGTGCCTGCTGGTCCAGGTGGAAAACCTGGAGGGCCTGGCCAACCTCGACGCGATCGCCGCCGTCGAGGGCGTCGACGGCGTGTTCATCGGTCCGGCCGACCTCAGCGCAGCCATGGGCCATCGCGGCAATCCAGGCCATCCCGAGGTGCAGGCGGCCATAGAGGACGCCATCCACCGCATCCGCACGGCCGGCAAGGCCGCCGGCATCCTCTCCGCCGACGAGACACTGGCGCGGCGCTACCTGGAGCTGGGCTGCGCGTTCGTCGCGGTGGGCGTGGACACCAGCCTGCTGATGCGTTCGCTGCGCGAGCTGGCGGGGCGCTTCAAGGGCGGCGCGCCGGCGCCGTCCGCCAGTTCCTCGGTCTACGGCTGA
Protein Properties
Protein Residues: 268
Protein Molecular Weight: 28.2 kDa
Protein Theoretical pI: 5.1
Hydropathicity (GRAVY score): 0.104
Charge at pH 7 (predicted): -5.89
Protein Sequence: 
>PA4128
MDLPVNRFKQRLRSGEAQIGLWLGLADPYCAELAANAGFDWLLLDGEHAPNDLRSLLGQLQALAPYPGQPVIRPVQGDTALIKQLLDIGAQTLLVPMVDSAAQAEGLVRAVRYPPAGVRGVGSALARASRWNSVAEYLNHADEQMCLLVQVENLEGLANLDAIAAVEGVDGVFIGPADLSAAMGHRGNPGHPEVQAAIEDAIHRIRTAGKAAGILSADETLARRYLELGCAFVAVGVDTSLLMRSLRELAGRFKGGAPAPSASSSVYG
References
External Links:
Resource Link
Genome ID: PA4128
Entrez Gene ID: 881843
NCBI Protein ID: 15599323
General Reference: PaperBLAST - Find papers about PA4128 and its homologs