lipoate synthase lipoic acid synthetase (PA3996)

Identification
Name: lipoate synthase lipoic acid synthetase
Synonyms: lipA
Gene Name: lis
Enzyme Class: Not Available
Biological Properties
General Function: cofactor biosynthetic process, lipoate biosynthetic process
Specific Function: lipoate synthase activity, 4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding
Cellular Location: Cytoplasmic
KEGG Pathways:
  • lipoate biosynthesis and incorporation III (Bacillus) PWY-6987
  • lipoate biosynthesis and incorporation I PWY0-501
  • lipoate biosynthesis and incorporation (glycine cleavage system, yeast) PWY-7381
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Octanoylated-Gcv-H+PAMDB000289 → PROTEIN-LIPOYLLYSINE+PAMDB000175+PAMDB001583+PAMDB001633
    Octanoylated-Gcv-H + S-Adenosylmethionine → PROTEIN-LIPOYLLYSINE + L-Methionine + 5'-Deoxyadenosine + Hydrogen ion
    ReactionCard
    PAMDB000289 → Pyruvate-dehydrogenase-lipoate+PAMDB000175+PAMDB001583+PAMDB001633
    S-Adenosylmethionine → Pyruvate-dehydrogenase-lipoate + L-Methionine + 5'-Deoxyadenosine + Hydrogen ion
    ReactionCard
    PAMDB000289 → Oxo-glutarate-dehydrogenase-lipoyl+PAMDB000175+PAMDB001583+PAMDB001633
    S-Adenosylmethionine → Oxo-glutarate-dehydrogenase-lipoyl + L-Methionine + 5'-Deoxyadenosine + Hydrogen ion
    ReactionCard
    Octanoylated-domains+PAMDB000289 → Lipoyl-Protein-N6-lipoyllysine+PAMDB001583+PAMDB000175
    Octanoylated-domains + S-Adenosylmethionine → Lipoyl-Protein-N6-lipoyllysine + 5'-Deoxyadenosine + L-Methionine
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    lipoate synthase activity
    4 iron, 4 sulfur cluster binding
    catalytic activity
    iron-sulfur cluster binding
    Process
    cofactor biosynthetic process
    lipoate biosynthetic process
    Gene Properties
    Locus tag: PA3996
    Strand: -
    Entrez Gene ID: 878931
    Accession: NP_252685.1
    GI: 15599191
    Sequence start: 4476994
    Sequence End: 4477977
    Sequence Length: 983
    Gene Sequence: 
    >PA3996
ATGAGCACTGTTGTGGAGAAGTCCGGAGAAGCCAAGCCGGGCAAGGTGGAAGTCGGCGTGAAGCTGCGCGGCGCGGAAAAGGTCGCGCGGATTCCGGTGAAGATCATTCCCACCGAGGAACTGCCGAAGAAACCCGACTGGATCCGCGTGCGCATCCCGGTTTCCCCCGAGGTCGACCGCATCAAGCAACTGCTGCGCAAGCACAAGCTGCACAGCGTCTGCGAAGAGGCGTCCTGCCCGAACCTGGGCGAGTGCTTCTCCGGCGGCACCGCGACCTTCATGATCATGGGCGATATCTGCACCCGACGCTGCCCGTTCTGCGACGTCGGTCATGGCCGGCCGAAGCCGCTGGACGTCGACGAGCCGACCAACCTGGCCATCGCCATCGCCGACCTGCGGCTGAAGTACGTGGTGATCACCTCGGTGGACCGCGACGACCTGCGCGACGGCGGCGCCCAGCACTTCGCCGACTGCCTGCGCGAGATCCGCAAGCTGTCGCCGGGGATCCAGCTGGAAACCCTGGTGCCCGACTATCGCGGTCGCATGGACATCGCCCTGGAGATCACCGCCAACGAGCCGCCGGACGTGTTCAACCATAACCTGGAGACGGTACCGCGCCTGTACCGCTCCTCGCGGCCGGGCTCGGACTTCGAGTGGTCGCTGGACCTGCTGCAGAAGTTCAAGCAGATGGTTCCGCACGTACCGACCAAGTCCGGGCTGATGCTCGGCCTGGGCGAGACCGACGACGAGGTCATCGAGGTCATGCAGCGGATGCGCGAGCACGACATCGACATGCTGACCCTCGGCCAGTACCTGCAGCCGTCGCGCAACCACCTGCCGGTGCAGCGCTTCGTGCATCCGGACACCTTCGCCTGGTTCGCCGAGGAAGGCGAGAAGATGGGCTTCAAGAACGTCGCGTCCGGCCCGCTGGTGCGTTCGTCCTACCATGCCGACCAGCAGGCGCACGGCAACAAGATCGGCTGA
    Protein Properties
    Protein Residues: 327
    Protein Molecular Weight: 36.7 kDa
    Protein Theoretical pI: 6.9
    Hydropathicity (GRAVY score): -0.398
    Charge at pH 7 (predicted): -0.55
    Protein Sequence: 
    >PA3996
MSTVVEKSGEAKPGKVEVGVKLRGAEKVARIPVKIIPTEELPKKPDWIRVRIPVSPEVDRIKQLLRKHKLHSVCEEASCPNLGECFSGGTATFMIMGDICTRRCPFCDVGHGRPKPLDVDEPTNLAIAIADLRLKYVVITSVDRDDLRDGGAQHFADCLREIRKLSPGIQLETLVPDYRGRMDIALEITANEPPDVFNHNLETVPRLYRSSRPGSDFEWSLDLLQKFKQMVPHVPTKSGLMLGLGETDDEVIEVMQRMREHDIDMLTLGQYLQPSRNHLPVQRFVHPDTFAWFAEEGEKMGFKNVASGPLVRSSYHADQQAHGNKIG
    References
    External Links:
    Resource Link
    Genome ID: PA3996
    Entrez Gene ID: 878931
    NCBI Protein ID: 15599191
    General Reference: PaperBLAST - Find papers about PA3996 and its homologs