Cytosol aminopeptidase (PA3831)

Identification
Name: Cytosol aminopeptidase
Synonyms:
  • Aminopeptidase A/I
  • Leucine aminopeptidase
  • LAP
  • Leucyl aminopeptidase
Gene Name: pepA
Enzyme Class:
Biological Properties
General Function: Involved in aminopeptidase activity
Specific Function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Cysteinylglycine + Water → L-Cysteine + Glycine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Cysteinylglycine + Water ↔ L-Cysteine + Glycine
ReactionCard
R-S-Cysteinylglycine+Thumb ↔ S-Substituted L-cysteine+Thumb
R-S-Cysteinylglycine + Water ↔ S-Substituted L-cysteine + Glycine
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
Cysteinylglycine + Water → L-Cysteine + Glycine
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Water + L-Prolinylglycine → Glycine + L-Proline
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000028CysteinylglycineMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB000152L-CysteineMetaboCard
PAMDB000064L-ProlineMetaboCard
PAMDB001645L-ProlinylglycineMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular
intracellular part
Function
aminopeptidase activity
binding
catalytic activity
cation binding
exopeptidase activity
hydrolase activity
ion binding
manganese ion binding
metal ion binding
metalloexopeptidase activity
metallopeptidase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
transition metal ion binding
Process
macromolecule metabolic process
metabolic process
protein metabolic process
proteolysis
Gene Properties
Locus tag: PA3831
Strand: +
Entrez Gene ID: 879865
Accession: NP_252520.1
GI: 15599026
Sequence start: 4288943
Sequence End: 4290430
Sequence Length: 1487
Gene Sequence: 
>PA3831
ATGGAATTCCTTGTTAAAAGCGTACGCCCGGAAACCCTGAAAACCGCCACCCTGGTGCTCGCCGTAGGCGAAGGCCGCAAGCTCGGCGCCAGCGCCAAGGCGGTCGACGACGCCACCGGCGGCGCCATCAGCGCAGTGCTCAAGCGTGGCGACCTGGCCGGCAAGGTCGGCCAGACCCTGCTCCTGCAGAGCCTGCCCAATCTCAAGGCCGAGCGCGTGCTGCTGGTCGGCGCCGGCAAGGAGCGCGAACTGGGCGACCGCCAGTACCGCAAGCTGGCCTCCGCCGTGCTGTCGACCCTCAAGGGCCTGGCCGGCGCCGATGCCGCGCTGGCCCTCGGCGATCTCGCGGTGAAAGGCCGCGATGCCCACGCGAAGGCGCGTCTGCTGGTGGAAACCCTGGCCGATGGCCTGTACGTGTTCGATCGCTACAAGAGCCAGAAAGCCGAGCCGCTGAAACTGAAGAAGCTGACCCTGCTCGCCGACAAGGCCGACAGCGCCGCCGTCGAGCAAGGCAGCAAGGAAGCCCAGGCCATCGCCAATGGCATGGCCCTGACCCGTGATCTCGGCAACCTGCCGCCGAACGTCTGCCATCCGACGTTCCTCGGCGAGCAGGCCAAGGGCCTGGCCAAGGAGTTCAAGGGCCTGAAGGTCGAGGTCCTCGACGAGAAGAAACTGCGCGAGCTGGGCATGGGCTCGTTCCTCGCCGTCGCCCAGGGCAGCGACCAGCCGCCGCGGCTGATCGTCCTGCAATACAACGGCGCGAAGAAGGACCAGGCCCCGCACGTGCTGGTCGGCAAGGGCATCACCTTCGACACCGGCGGCATCAGCCTCAAGCCGGGCCTGGGCATGGACGAGATGAAGTTCGACATGTGCGGCGCCGCCAGCGTCTTCGGCACCTTCCGCGCGGTGCTCGAACTGCAGTTGCCGATCAACCTGGTCGGCCTGCTGGCCTGCGCCGAGAACATGCCCAGCGGCGGAGCCACCCGTCCGGGCGACATCGTCACCACCATGAGCGGGCAGACCGTCGAGATCCTCAACACCGACGCCGAAGGGCGCCTGGTGCTGTGCGATGCACTGACCTACGCCGAGCGCTTCAAGCCGCAGTCGGTGATCGACATCGCCACCCTCACCGGCGCCTGCATCGTCGCCCTGGGCAGCAACACCTCGGGCCTTATGGGCAACAACGAAGCGCTGGTCAGGCAACTGCTCAAGGCCGGCGAGTTCGCCGACGACCGCGCCTGGCAATTGCCGCTGTTCGACGAATACCAGGAACAGCTGGACAGCCCGTTCGCCGACATCGCCAACATCGGCGGGCCGAAGGCCGGCACCATCACCGCCGGCTGCTTCCTCTCGCGCTTCGCCAAGAAATACCACTGGGCGCACCTGGACATCGCCGGCACCGCCTGGATCAGCGGCGGCAAGGACAAAGGCGCCACCGGCCGCCCGGTTCCGTTGTTGACCCAGTACCTGCTGGAACGGGCCAAGTGA
Protein Properties
Protein Residues: 495
Protein Molecular Weight: 52.3 kDa
Protein Theoretical pI: 8.74
Hydropathicity (GRAVY score): -0.007
Charge at pH 7 (predicted): 6.04
Protein Sequence: 
>PA3831
MEFLVKSVRPETLKTATLVLAVGEGRKLGASAKAVDDATGGAISAVLKRGDLAGKVGQTLLLQSLPNLKAERVLLVGAGKERELGDRQYRKLASAVLSTLKGLAGADAALALGDLAVKGRDAHAKARLLVETLADGLYVFDRYKSQKAEPLKLKKLTLLADKADSAAVEQGSKEAQAIANGMALTRDLGNLPPNVCHPTFLGEQAKGLAKEFKGLKVEVLDEKKLRELGMGSFLAVAQGSDQPPRLIVLQYNGAKKDQAPHVLVGKGITFDTGGISLKPGLGMDEMKFDMCGAASVFGTFRAVLELQLPINLVGLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDALTYAERFKPQSVIDIATLTGACIVALGSNTSGLMGNNEALVRQLLKAGEFADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAGCFLSRFAKKYHWAHLDIAGTAWISGGKDKGATGRPVPLLTQYLLERAK
References
External Links:
Resource Link
Genome ID: PA3831
Entrez Gene ID: 879865
NCBI Protein ID: 15599026
General Reference: PaperBLAST - Find papers about PA3831 and its homologs