Protoheme IX farnesyltransferase (PA1321)

Identification
Name: Protoheme IX farnesyltransferase
Synonyms:
  • Heme B farnesyltransferase
  • Heme O synthase
Gene Name: cyoE
Enzyme Class: Not Available
Biological Properties
General Function: Involved in protoheme IX farnesyltransferase activity
Specific Function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Farnesyl pyrophosphate + Water + Heme → Heme O + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Heme + Water + Farnesyl pyrophosphate ↔ Heme O + Pyrophosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Farnesyl pyrophosphate+Thumb → Thumb+Pyrophosphate
ferroheme b + Water + Farnesyl pyrophosphate + Farnesyl pyrophosphate → Heme O + Pyrophosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Farnesyl pyrophosphate + Water + Heme → Heme O + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Heme + Water + Farnesyl pyrophosphate ↔ Heme O + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Heme + Farnesyl pyrophosphate + Water ↔ Heme O + Pyrophosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000210Farnesyl pyrophosphateMetaboCard
PAMDB006369ferroheme bMetaboCard
PAMDB000481HemeMetaboCard
PAMDB000278Heme OMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
catalytic activity
farnesyltranstransferase activity
prenyltransferase activity
protoheme IX farnesyltransferase activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
heme biosynthetic process
heme O biosynthetic process
metabolic process
nitrogen compound metabolic process
porphyrin biosynthetic process
porphyrin metabolic process
tetrapyrrole metabolic process
Gene Properties
Locus tag: PA1321
Strand: +
Entrez Gene ID: 881575
Accession: NP_250012.1
GI: 15596518
Sequence start: 1432037
Sequence End: 1432927
Sequence Length: 890
Gene Sequence: 
>PA1321
GTGAAGCTGAAACGCTATCTCCTGGTGGCCAAGCCGGGAATCATCTTCGGCAACCTGATCGCGGTGGCGGGGGGATACTTCCTCGCCGCCCGCGGCAGCGTCGAGCCGATGCTGTTGCTGGCCACGGTCATCGGCCTGTCGCTGGTGGTCGCCAGTGGGTGCGTGCTGAACAACTGCATCGACCGCGACATCGACCGGCACATGGAGCGGACCCGCGGGCGAGTCACCGTGACCGGGCAGATCTCGCTGAAGGCTGCCCTGGCCCACGGCCTGGTCCTCGGGGTCGCCGGCTTCGGCCTGCTGTGGTGGCGGACCAACCCGCTGACCACCGCGCTGGCCGGCTTCGGCTACTTCGTCTACGTCGGCCTGTACAGCCTGTGGTTCAAGCGTCGTTCGCAGTACGGCACGCTGGTCGGCAGCCTCTCCGGGGCGATGCCGCCGGTGGTCGGCTACTGCGCGGTGAGCGGCCAGTTCGACGCCGGCGCCGCCTCGCTGCTGGCGATCTTCTGCCTGTGGCAGATGCCGCACTCCTATGCCATCGCCATCTTCCGCCTGAAGGACTACGAGGCGGCTGGCATCCCGGTGCTGCCGGTGGCGCGCGGCATCGCGGTGACCAAGATCCACATCGTGCTCTACATCCTCGCCTTCATGGCGGCGACCCTCGCCTTGTGCCTGGGCGGCTACGCCGGCTACGGCTACCTGCTGGTGGCGGTGGCGGTGAGCCTGTGGTGGCTGGCCATCGCCCTGACCGGCTACTGGACCGCCGACGACCGGGTCTGGGCGCGCAAGCTGTTCGCCTTCTCCATCGTCGCCATCACCGCGCTGAGCGTGATGATGTCCATCGACTTCCAGGTGGCGCCCGCCACCCATCTGGTCGCCTCGCTGTTCTGA
Protein Properties
Protein Residues: 296
Protein Molecular Weight: 31.8 kDa
Protein Theoretical pI: 9.79
Hydropathicity (GRAVY score): 0.87
Charge at pH 7 (predicted): 12.02
Protein Sequence: 
>PA1321
MKLKRYLLVAKPGIIFGNLIAVAGGYFLAARGSVEPMLLLATVIGLSLVVASGCVLNNCIDRDIDRHMERTRGRVTVTGQISLKAALAHGLVLGVAGFGLLWWRTNPLTTALAGFGYFVYVGLYSLWFKRRSQYGTLVGSLSGAMPPVVGYCAVSGQFDAGAASLLAIFCLWQMPHSYAIAIFRLKDYEAAGIPVLPVARGIAVTKIHIVLYILAFMAATLALCLGGYAGYGYLLVAVAVSLWWLAIALTGYWTADDRVWARKLFAFSIVAITALSVMMSIDFQVAPATHLVASLF
References
External Links:
Resource Link
Genome ID: PA1321
Entrez Gene ID: 881575
NCBI Protein ID: 15596518
General Reference: PaperBLAST - Find papers about PA1321 and its homologs