Heme (PAMDB000481)

General function:

Involved in ferrochelatase activity

Specific function:

Catalyzes the ferrous insertion into protoporphyrin IX

Gene Name:

hemH

Locus Tag:

PA4655

Molecular weight:

38.6 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Locus Tag:

PA1475

Molecular weight:

25 kDa

Reactions

General function:

Involved in protein complex assembly

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmC

Locus Tag:

PA1477

Molecular weight:

28.3 kDa

General function:

Involved in heme transporter activity

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmB

Locus Tag:

PA1476

Molecular weight:

23.4 kDa

General function:

Involved in protoheme IX farnesyltransferase activity

Specific function:

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

Gene Name:

cyoE

Locus Tag:

PA1321

Molecular weight:

31.8 kDa

General function:

Involved in protein-heme linkage

Specific function:

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

Gene Name:

ccmE

Locus Tag:

PA1479

Molecular weight:

17.2 kDa