Identification |
Name: |
Methionyl-tRNA formyltransferase |
Synonyms: |
Not Available |
Gene Name: |
fmt |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in methionyl-tRNA formyltransferase activity |
Specific Function: |
Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP |
Cellular Location: |
Not Available |
KEGG Pathways: |
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KEGG Reactions: |
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L-Methionyl-tRNA | + | ![Thumb](/molecules/PAMDB000213thumb.png) | ↔ | ![Thumb](/molecules/PAMDB000424thumb.png) | + | N-Formylmethionyl-tRNA |
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SMPDB Reactions: |
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Tetrahydrofolic acid | + | N-formylmethionyl-tRNA(fMet) | + | ![Thumb](/molecules/PAMDB000424thumb.png) | ? | L-methionyl-tRNA(Met) | + | 10-Formyltetrahydrofolate | + | ![Thumb](/molecules/PAMDB000213thumb.png) |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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![Thumb](/molecules/PAMDB000213thumb.png) | + | L-Methionyl-tRNA (Met) | → | N-Formylmethionyl-tRNA | + | ![Thumb](/molecules/PAMDB001633thumb.png) | + | ![Thumb](/molecules/PAMDB000424thumb.png) |
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![Thumb](/molecules/PAMDB000213thumb.png) | + | L-methionyl-tRNA(fMet) | → | ![Thumb](/molecules/PAMDB000424thumb.png) | + | N-formylmethionyl-tRNA(fMet) |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Function |
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catalytic activity | glycine hydroxymethyltransferase activity | hydroxymethyl-, formyl- and related transferase activity | methionyl-tRNA formyltransferase activity | methyltransferase activity | transferase activity | transferase activity, transferring one-carbon groups | Process |
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biosynthetic process | cellular macromolecule biosynthetic process | macromolecule biosynthetic process | metabolic process | translation |
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Gene Properties |
Locus tag: |
PA0018 |
Strand: |
- |
Entrez Gene ID: |
879258 |
Accession: |
NP_248708.1 |
GI: |
15595216 |
Sequence start: |
20068 |
Sequence End: |
21012 |
Sequence Length: |
944 |
Gene Sequence: |
>PA0018
ATGAGCCAAGCATTGCGCATCGTCTTCGCCGGAACCCCGGAATTCGCCGCCGAGCATCTCAAGGCCCTGCTCGACACCCCACATCGGATCGTCGCCGTCTACACCCAGCCTGACCGGCCGGCCGGCCGCGGGCAGAAACTGATGCCCAGCGCGGTGAAGAGCCTGGCCCTGGAGCATGGCCTGCCGGTCATGCAGCCGCAGAGCCTGCGTAATGCCGAGGCCCAGGCGGAGCTGGCGGCCCTGCGCGCGGACCTGATGGTGGTGGTCGCCTATGGCCTGATCCTGCCCCAGGCGGTACTCGATATCCCGCGCCTGGGCTGCATCAACAGCCACGCCTCGCTGCTGCCGCGCTGGCGCGGCGCCGCGCCGATCCAGCGCGCGGTGGAAGCCGGCGACGCGGAGAGCGGCGTCACCGTGATGCAGATGGAAGCAGGGCTCGACACCGGCCCGATGCTGCTCAAGGTGAGCACGCCGATTTCCGCCGCGGACACCGGCGGCAGCCTGCACGATCGGCTCGCCGCGCTCGGCCCGAAAGCGGTGATCGAAGCCATCGCCGGCCTGGCCGCCGGCACCCTGCATGGCGAGATCCAGGACGACGCCCTGGCCACCTACGCGCACAAGCTGAACAAGGACGAGGCACGCCTCGACTGGAGCCGTCCGGCCGTCGAACTGGAGCGCCAGGTCCGCGCCTTCACCCCCTGGCCGGTCTGCCACACCAGCCTCGCCGATGCGCCGCTGAAAGTCCTCGGCGCCAGCCTGGGGCAGGGCAGCGGGGCGCCCGGAACCATCCTCGAGGCCAGCCGCGACGGCCTGCTGGTCGCCTGCGGCGAAGGCGCCCTGCGCCTGACCCGCCTGCAATTGCCTGGCGGCAAGCCACTGGCCTTCGCCGACCTCTACAACAGCCGCCGCGAGCAATTCGCCGCCGGCCAGGTGCTCGGCCAATGA |
Protein Properties |
Protein Residues: |
314 |
Protein Molecular Weight: |
33 kDa |
Protein Theoretical pI: |
6.96 |
Hydropathicity (GRAVY score): |
0.068 |
Charge at pH 7 (predicted): |
-0.17 |
Protein Sequence: |
>PA0018
MSQALRIVFAGTPEFAAEHLKALLDTPHRIVAVYTQPDRPAGRGQKLMPSAVKSLALEHGLPVMQPQSLRNAEAQAELAALRADLMVVVAYGLILPQAVLDIPRLGCINSHASLLPRWRGAAPIQRAVEAGDAESGVTVMQMEAGLDTGPMLLKVSTPISAADTGGSLHDRLAALGPKAVIEAIAGLAAGTLHGEIQDDALATYAHKLNKDEARLDWSRPAVELERQVRAFTPWPVCHTSLADAPLKVLGASLGQGSGAPGTILEASRDGLLVACGEGALRLTRLQLPGGKPLAFADLYNSRREQFAAGQVLGQ |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA0018 and its homologs
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