Reaction 21863

Reaction Details
Reaction: Thumb
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:TRYPSYN-RXN
References:
  • Crawford IP, Yanofsky C (1958). "On the separation of the tryptophan synthetase of Escherichia coli into two protein components." Proc Natl Acad Sci U S A 44(12);1161-70. PMID: 16590328
  • Hutter R, Niederberger P, DeMoss JA (1986). "Tryptophan biosynthetic genes in eukaryotic microorganisms." Annu Rev Microbiol 40;55-77. PMID: 3535653
  • Hyde CC, Ahmed SA, Padlan EA, Miles EW, Davies DR (1988). "Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium." J Biol Chem 263(33);17857-71. PMID: 3053720
  • Woehl E, Dunn MF (1999). "Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase alpha-, beta-, and alpha beta-reactions." Biochemistry 38(22);7131-41. PMID: 10353823