Reaction Details
Reaction: Thumb
precorrin-6B + 2 S-adenosyl-L-methionine → precorrin-8x + 2 S-adenosyl-L-homocysteine + CO2 + H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:2.1.1.132-RXN
References:
  • Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J (1992). "Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product." J Bacteriol 174(3);1050-2. PMID: 1732195
  • Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ (2012). "An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis." Nat Chem Biol 8(11);933-40. PMID: 23042036