Identification
Name: precorrin-6y-dependent methyltransferase CobL
Synonyms: cbiT; cbiE
Gene Name: cobL
Enzyme Class: Not Available
Biological Properties
General Function: cofactor biosynthetic process, metabolic process, cobalamin biosynthetic process
Specific Function: protein methyltransferase activity, methyltransferase activity
Cellular Location: Cytoplasmic
KEGG Pathways:
  • adenosylcobalamin biosynthesis II (late cobalt incorporation) P381-PWY
  • cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) PWY-7376
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Thumb
    precorrin-6B + 2 S-adenosyl-L-methionine → precorrin-8x + 2 S-adenosyl-L-homocysteine + CO2 + H+
    ReactionCard
    Thumb
    precorrin-6B + S-adenosyl-L-methionine + H+ → precorrin-7 + S-adenosyl-L-homocysteine + CO2
    ReactionCard
    Thumb
    precorrin-7 + S-adenosyl-L-methionine → precorrin-8x + S-adenosyl-L-homocysteine + 2 H+
    ReactionCard
    Complex Reactions: Not Available
    Transports: Not Available
    Metabolites: Not Available
    GO Classification:
    Function
    protein methyltransferase activity
    methyltransferase activity
    Process
    cofactor biosynthetic process
    metabolic process
    cobalamin biosynthetic process
    Gene Properties
    Locus tag: PA2907
    Strand: +
    Entrez Gene ID: 882678
    Accession: NP_251597.1
    GI: 15598103
    Sequence start: 3261522
    Sequence End: 3262769
    Sequence Length: 1247
    Gene Sequence:
    >PA2907
    GTGTCATCGGCAGACTCGACGCCGCCCTGGCTGACCCTGGTGGGCATCGGCGAGGACGGTTATCCCGGCCTCGGCAAGCAGGCCCGGCGTGCCCTGCTGCAAGCCAGCCGGATCGTCGGCGCGGCGCGCCAGCTGGAACTGCTGCCGCCGTGCATCGGCGCCGCCCGCGAAACCTGGCCGACGCCGTTCTCCCTGGAACCATTGCTGGCCCGGCGCGGCCAGCCGACCTGCGTGCTGGCCAGCGGCGACCCGATGCTGTTCGGCGTCGGCGCCAGTCTCGCCCGGCAACTGCCGGCGACCGAACTGCGGGTCCTGCCGGCGCCTTCCTCCCTCTCGCTGGCCGCCGCCCGCCTCGGCTGGGCCCTGCAGGAGGTCGCCTGCCTGTCGCTGGTGGCGCGCCCGCTGGCAGCGCTGCAGGCACAGGTCCACGACGGCCGGCGCCTGCTGGTCCTCAGCAACGACGGCGACAGCCCGGCCGCCATCGCCCGCCTGTTGAACGCCCGTGGCTTCGGCGCCAGTCGCCTGAGCGTGCTGGAACACCTCGGCGGGCCGCTCGAGCGCCGTCTCGACGGCCTCGCTGGCGACTGGTCGCTGCCGCGCGCCGCCGATCTCAACCTGGTGGCGGTGGAATGCCGCGCCGGCGCCGGCGCCGTGCGCCTGCCGCTGACCCCGGGCCTGGCCGACGAGGCCTATCGCCACGACGGCCAGTTGACCAAGCGCGACGTCCGCGCCGTGACCCTGGCGCGCCTGGCGCCCTGCCCCGGCGAGCTGCTCTGGGACGTCGGCGCCGGTTGCGGCTCCATCGGCATCGAATGGATGCGCGCGCACCCCAGTTGCCGGGCGATCGCCATCGAAGCCAACGACGAGCGCCAGGAACATATCCGCCACAACCGCGACGCCCTCGGCGTACCGACCCTACACCTGGTCGCCGGCAGCGCCCCGGAGGCCCTGCTGGAACTGCCCGAGCCGGACGCCATCTTCATCGGCGGCGGGGTCACCGCCGAGGGCGTGCTGGAAACCTGCTGGGAGCGCCTGCGGCCCGGCGGCCGCCTGCTCGCCAACGCGGTCACCCTGCAGAGCGAACGGGTGCTGCTCGACTGGCAGCAACGCCTGGGTGGCGACCTCACCCGCCTCGGCGTCGCCCACGCGCGACCACTGGGCGGTTTCGACACCTGGCGCCAGGCCTTGCCGATCACCCTGCTGGAATTGCGCAAGCCCGCCGCCAGGAAGCCTCCCCGCGATGCGTGA
    Protein Properties
    Protein Residues: 415
    Protein Molecular Weight: 44.1 kDa
    Protein Theoretical pI: 8.02
    Hydropathicity (GRAVY score): 0.012
    Charge at pH 7 (predicted): 3.7
    Protein Sequence:
    >PA2907
    MSSADSTPPWLTLVGIGEDGYPGLGKQARRALLQASRIVGAARQLELLPPCIGAARETWPTPFSLEPLLARRGQPTCVLASGDPMLFGVGASLARQLPATELRVLPAPSSLSLAAARLGWALQEVACLSLVARPLAALQAQVHDGRRLLVLSNDGDSPAAIARLLNARGFGASRLSVLEHLGGPLERRLDGLAGDWSLPRAADLNLVAVECRAGAGAVRLPLTPGLADEAYRHDGQLTKRDVRAVTLARLAPCPGELLWDVGAGCGSIGIEWMRAHPSCRAIAIEANDERQEHIRHNRDALGVPTLHLVAGSAPEALLELPEPDAIFIGGGVTAEGVLETCWERLRPGGRLLANAVTLQSERVLLDWQQRLGGDLTRLGVAHARPLGGFDTWRQALPITLLELRKPAARKPPRDA
    References
    External Links:
    Resource Link
    Genome ID: PA2907
    Entrez Gene ID: 882678
    NCBI Protein ID: 15598103
    General Reference: PaperBLAST - Find papers about PA2907 and its homologs