Reaction Details
Reaction: Thumb
2-hydroxy-5-carboxymethylmuconate semialdehyde + NAD+ + H2O → 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+
Enzymes:
External Links:
ResourceLink
PseudoCyc Reaction ID:CHMS-DEHYDROGENASE-RXN
References:
  • Alonso JM, Garrido-Pertierra A (1982). "Carboxymethylhydroxymuconic semialdehyde dehydrogenase in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli." Biochim Biophys Acta 719(1);165-7. PMID: 6756482
  • Blakley ER (1977). "The catabolism of L-tyrosine by an Arthrobacter sp." Can J Microbiol 23(9);1128-39. PMID: 20216
  • Cooper RA, Skinner MA (1980). "Catabolism of 3- and 4-hydroxyphenylacetate by the 3,4-dihydroxyphenylacetate pathway in Escherichia coli." J Bacteriol 143(1);302-6. PMID: 6995433
  • Garrido-Peritierra A, Cooper RA (1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli." Eur J Biochem 1981;117(3);581-4. PMID: 7026235