Identification
Name: Thiol:disulfide interchange protein dsbA
Synonyms: Not Available
Gene Name: dsbA
Enzyme Class: Not Available
Biological Properties
General Function: Involved in protein disulfide oxidoreductase activity
Specific Function: Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by dsbB. It is required for pilus biogenesis
Cellular Location: Periplasm
KEGG Pathways:
    KEGG Reactions: Not Available
    SMPDB Reactions: Not Available
    PseudoCyc/BioCyc Reactions:
    Complex Reactions:
    Thumb+periplasmic protein disulfide isomerase I (reduced)Thumb+periplasmic protein disulfide isomerase I (oxidized)
    Ubiquinone-8 + periplasmic protein disulfide isomerase I (reduced) → Ubiquinol-8 + periplasmic protein disulfide isomerase I (oxidized)
    ReactionCard
    Menaquinone 8+periplasmic protein disulfide isomerase I (reduced)Thumb+periplasmic protein disulfide isomerase I (oxidized)
    Menaquinone 8 + periplasmic protein disulfide isomerase I (reduced) → Menaquinol 8 + periplasmic protein disulfide isomerase I (oxidized)
    ReactionCard
    Transports: Not Available
    Metabolites:
    PAMDB IDNameView
    PAMDB001653Menaquinol 8MetaboCard
    PAMDB000237Ubiquinol-8MetaboCard
    PAMDB001700Ubiquinone-8MetaboCard
    GO Classification:
    Component
    cell part
    outer membrane-bounded periplasmic space
    periplasmic space
    Function
    catalytic activity
    disulfide oxidoreductase activity
    oxidoreductase activity
    oxidoreductase activity, acting on a sulfur group of donors
    protein disulfide oxidoreductase activity
    Process
    cell redox homeostasis
    cellular homeostasis
    cellular process
    Gene Properties
    Locus tag: PA5489
    Strand: -
    Entrez Gene ID: 877731
    Accession: NP_254176.1
    GI: 15600682
    Sequence start: 6180942
    Sequence End: 6181577
    Sequence Length: 635
    Gene Sequence:
    >PA5489
    ATGCGTAACCTGATTCTCACCGCCATGCTGGCCATGGCCAGCCTGTTCGGCATGGCCGCCCAGGCCGACGACTATACCGCCGGCAAGGAATACGTCGAGCTGAGCAGCCCGGTGCCGGTGTCCCAGCCGGGCAAGATCGAAGTGGTGGAACTGTTCTGGTATGGCTGCCCGCATTGCTACGCGTTCGAGCCGACCATCGTGCCGTGGAGCGAGAAGCTGCCGGCAGATGTCCATTTCGTGCGCCTGCCTGCCCTGTTCGGCGGTATCTGGAACGTCCATGGGCAGATGTTCCTGACCCTGGAAAGCATGGGTGTCGAGCATGACGTACACAACGCCGTGTTCGAGGCGATCCACAAGGAGCACAAGAAGCTCGCCACTCCGGAAGAAATGGCCGATTTCCTCGCCGGCAAGGGCGTGGACAAGGAAAAATTCCTGAGCACCTATAATTCCTTTGCCATCAAGGGCCAGATGGAAAAGGCCAAGAAGCTGGCGATGGCCTACCAGGTCACCGGCGTACCGACCATGGTGGTCAATGGCAAATATCGCTTCGACATCGGCTCCGCCGGTGGTCCGGAGGAAACCCTCAAGCTGGCCGACTACCTGATCGAGAAAGAGCGCGCAGCGGCCAAGAAGTAG
    Protein Properties
    Protein Residues: 211
    Protein Molecular Weight: 23.4 kDa
    Protein Theoretical pI: 6.4
    Hydropathicity (GRAVY score): -0.064
    Charge at pH 7 (predicted): -2.38
    Protein Sequence:
    >PA5489
    MRNLILTAMLAMASLFGMAAQADDYTAGKEYVELSSPVPVSQPGKIEVVELFWYGCPHCYAFEPTIVPWSEKLPADVHFVRLPALFGGIWNVHGQMFLTLESMGVEHDVHNAVFEAIHKEHKKLATPEEMADFLAGKGVDKEKFLSTYNSFAIKGQMEKAKKLAMAYQVTGVPTMVVNGKYRFDIGSAGGPEETLKLADYLIEKERAAAKK
    References
    External Links:
    Resource Link
    Genome ID: PA5489
    Entrez Gene ID: 877731
    NCBI Protein ID: 15600682
    General Reference: PaperBLAST - Find papers about PA5489 and its homologs