Uroporphyrinogen-III synthase (PA5259)

Identification
Name: Uroporphyrinogen-III synthase
Synonyms:
  • UROS
  • Hydroxymethylbilane hydrolyase [cyclizing]
  • Uroporphyrinogen-III cosynthase
Gene Name: hemD
Enzyme Class:
Biological Properties
General Function: Involved in uroporphyrinogen-III synthase activity
Specific Function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
Hydroxymethylbilane ↔ Water + Uroporphyrinogen III
ReactionCard
SMPDB Reactions:
Thumb → Thumb+Thumb
Hydroxymethylbilane → Water + Uroporphyrinogen III
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
Hydroxymethylbilane ↔ Water + Uroporphyrinogen III
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
Hydroxymethylbilane → Uroporphyrinogen III + Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000271HydroxymethylbilaneMetaboCard
PAMDB000248Uroporphyrinogen IIIMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carbon-oxygen lyase activity
catalytic activity
hydro-lyase activity
lyase activity
uroporphyrinogen-III synthase activity
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
metabolic process
tetrapyrrole biosynthetic process
Gene Properties
Locus tag: PA5259
Strand: -
Entrez Gene ID: 879724
Accession: NP_253946.1
GI: 15600452
Sequence start: 5920742
Sequence End: 5921497
Sequence Length: 755
Gene Sequence: 
>PA5259
GTGAGCGGCTGGCGGCTCCTGCTGACGCGCCCCGACGAGGAGTGCGCGGCCCTGGCCGCCAGCCTCGGCGAGGCGGGCGTCCATAGCAGCAGCCTGCCGCTGTTGGCGATCGATCCGCTGGAAGAAACCCCGGAGCAGCGTACGCTGATGCTCGACCTGGACCGCTACTGCGCGGTGGTGGTGGTCAGCAAGCCGGCGGCGCGCCTGGGGCTGGAGCGGCTCGACCGCTACTGGCCGCAGCCGCCGCAGCAGACCTGGTGCAGCGTCGGCGCGGCGACCGCGGCGATCCTCGAGGCCTACGGCCTCGACGTAACCTACCCTGAACAGGGCGACGACAGCGAAGCGTTGCTGGCGCTGCCGGCGTTCCAGGATTCCCTGCGCGTGCACGATCCGAAAGTGCTGATCATGCGCGGCGAAGGTGGCCGAGAATTCCTCGCCGAGCGCCTGCGCGGCCAAGGCGTGCAGGTGGACTACCTGCCACTCTACCGGCGCCGGGCTCCGGACTATCCGGCCGGAGAGCTGCTGGCAAGGGTGCGGGCGGAACGCCTGAACGGCCTGGTGGTCAGCAGTGGACAGGGTTTGCAAAATCTGTATCAGTTGGCGGCAGCCGATTGGCCCGAGATAGGCCGGTTGCCGCTGTTCGTACCCAGCCCGCGGGTCGCCGAGATGGCGCGCGAACTGGGTGCGCAACGGGTGATTGATTGCCGGGGCGCGAGCGCGCCGGCCTTGCTGGCGGCCCTGACGAGCGCCGCCTAG
Protein Properties
Protein Residues: 251
Protein Molecular Weight: 27.2 kDa
Protein Theoretical pI: 4.76
Hydropathicity (GRAVY score): -0.053
Charge at pH 7 (predicted): -6.64
Protein Sequence: 
>PA5259
MSGWRLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKPAARLGLERLDRYWPQPPQQTWCSVGAATAAILEAYGLDVTYPEQGDDSEALLALPAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAERLNGLVVSSGQGLQNLYQLAAADWPEIGRLPLFVPSPRVAEMARELGAQRVIDCRGASAPALLAALTSAA
References
External Links:
Resource Link
Genome ID: PA5259
Entrez Gene ID: 879724
NCBI Protein ID: 15600452
General Reference: PaperBLAST - Find papers about PA5259 and its homologs