P. aeruginosa Metabolome Database Protein PA4829

Identification

Name:

dihydrolipoamide dehydrogenase 3 LPD-3

Synonyms:

Not Available

Gene Name:

lpd3

Enzyme Class:

Not Available

Biological Properties

General Function:

oxidation-reduction process, cell redox homeostasis

Specific Function:

dihydrolipoyl dehydrogenase activity, oxidoreductase activity, flavin adenine dinucleotide binding, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

Cellular Location:

Cytoplasmic

KEGG Pathways:

superpathway of glyoxylate bypass and TCA TCA-GLYOX-BYPASS
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GLYCOLYSIS-TCA-GLYOX-BYPASS
pyruvate fermentation to acetate and lactate I P41-PWY
N¹⁰-formyl-tetrahydrofolate biosynthesis 1CMET2-PWY
pyruvate decarboxylation to acetyl CoA PYRUVDEHYD-PWY
TCA cycle I (prokaryotic) TCA
anaerobic respiration ANARESP1-PWY
pyruvate fermentation to acetate II PWY-5482
glutamate degradation III GLUTAMOLYSIS-PWY
2-oxoglutarate decarboxylation to succinyl-CoA PWY-5084
glycine cleavage GLYCLEAV-PWY
glycine biosynthesis II GLYCINE-SYN2-PWY
2-oxoisovalerate decarboxylation to isobutanoyl-CoA PWY-5046

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

glycine + a tetrahydrofolate + NAD⁺ → a 5,10-methylene-tetrahydrofolate + ammonium + CO₂ + NADH
ReactionCard

pyruvate + coenzyme A + NAD⁺ → acetyl-CoA + CO₂ + NADH
ReactionCard

pyruvate + lipoamide → S-acetyldihydrolipoamide + CO₂
ReactionCard

acetyl-CoA + dihydrolipoamide ← S-acetyldihydrolipoamide + coenzyme A
ReactionCard

2-oxoglutarate + coenzyme A + NAD⁺ → succinyl-CoA + CO₂ + NADH
ReactionCard

a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + a tetrahydrofolate ↔ a [glycine-cleavage complex H protein] N⁶-dihydrolipoyl-L-lysine + a 5,10-methylene-tetrahydrofolate + ammonium
ReactionCard

glycine + a [glycine-cleavage complex H protein] N⁶-lipoyl-L-lysine + H⁺ ↔ a [glycine-cleavage complex H protein] N⁶-aminomethyldihydrolipoyl-L-lysine + CO₂
ReactionCard

succinyl-lipoate + coenzyme A → succinyl-CoA + DIHYDROLIPOYL-OXO-GLUT-E2
ReactionCard

a [lipoyl-carrier protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺ = a [lipoyl-carrier protein]-N⁶-lipoyl-L-lysine + NADH + H⁺
ReactionCard

2-oxoglutarate + a [2-oxoglutarate dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + H⁺ → a [2-oxoglutarate dehydrogenase E2 protein] N⁶-S-succinyldihydrolipoyl-L-lysine + CO₂
ReactionCard

an [apo BCAA dehydrogenase E2 protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺ = an [apo BCAA dehydrogenase E2 protein] N⁶-lipoyl-L-lysine + NADH + H⁺
ReactionCard

a [glycine-cleavage complex H protein] N⁶-dihydrolipoyl-L-lysine + NAD⁺ ↔ a [glycine-cleavage complex H protein] N⁶-lipoyl-L-lysine + NADH + H⁺
ReactionCard

Complex Reactions:

Not Available

Transports:

Not Available

Metabolites:

Not Available

GO Classification:

Function
dihydrolipoyl dehydrogenase activity
oxidoreductase activity
flavin adenine dinucleotide binding
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
Process
oxidation-reduction process
cell redox homeostasis

Gene Properties

Locus tag:

PA4829

Strand:

Entrez Gene ID:

882254

Accession:

NP_253516.1

GI:

15600022

Sequence start:

5420323

Sequence End:

5421726

Sequence Length:

1403

Gene Sequence:

>PA4829
ATGATGGAAAGCTATGACGTGATCGTGATCGGCGCCGGTCCGGGGGGCTACAACGCTGCCATTCGCGCCGGCCAGCTGGGCCTGAAGGTGGCCTGCGTGGAGGGTCGCGAAACCCTCGGCGGGACTTGCCTGAACGTCGGCTGCATGCCGTCCAAGGCCCTGTTGCACGCCTCGGAGCTATACGCCGCGGCGAGCGGCGGCGAGTTCGCCCGGCTCGGCATCCGGGTCAGCCCGGAACTGGACCTGGCGCAGATGATGAAGCAGAAGGACGAGAGCGTCGCCGCCCTGACCCGTGGCGTCGAATTCCTCTTCCGCAAGCACAAGGTGCAGTGGATCAAGGGCTGGGCGCGCTTGCAAGGCGAGGGCCGGGTCGGCGTGGCCCTTGCCGACGGCGGCCACGCGCAACTGGAGGCGCGCGACATCGTTATCGCCACCGGTTCGGAACCGGCGCCGCTGCCCGGCGTGCCTGTGGACAACCAGCGCATCCTCGACTCCACCGGCGCCCTGGAGTTGGTCGAAGTGCCTCGCCACCTGGTGGTGATCGGCGCCGGCGTGATCGGCCTGGAGCTTGGTTCGGTCTGGCGCCGGCTGGGCGCACAGGTCACGGTGCTGGAGTACCTCGAGCGGATCTGCCCGGGGCTGGATGGGGAAACCGCAAGGACCCTGCAGCGCGCCCTGACCCGCCAGGGCATGCGGTTTCGCCTCGGCACCCGCGTGGTCGCCGCGCGCAGTGGCGAGCAGGGCGTCGAACTCGACCTGCAACCGGCCGCCGGCGGCGCTACGGAATCGCTGCAGGCGGACTACGTGCTGGTGGCCATCGGCCGGCGCCCCTATACCGAAGGACTGGGGCTGGAGACGGTCGGCCTGGCCAGCGATCGTCGCGGCATGCTGGAGAACCAGGGACAGCGCAGCGCGGCGCCGGGCGTCTGGGTGATCGGCGACGTGACCTCGGGACCGATGCTGGCGCACAAGGCCGAGGAAGAGGCGATCGTCTGCATCGAGCGGATCGCCGGGCATGCGGCGGAGATGAACGCCGAGGTGATTCCGTCGGTCATCTACACCCAGCCGGAAGTGGCCAGCGTCGGCCTCGGCGAGGAGCAGCTGCAGGCGGCGAGGCGCGAGTACAAGGTCGGACGCTTCCCGTTCAGCGCCAACAGCCGGGCGAAGATCAACCACGAGAGCGAAGGCTTCATCAAGATCCTCTCCGATGCCCGCAGCGACCAGGTGCTCGGCGTGCACATGATCGGGCCGGGCGTCAGCGAGATGATCGGCGAAGCCTGCGTGGCCATGGAGTTCAGCGCCTCGGCGGAGGACCTCGCGCTGACCTGCCATCCGCATCCGACCCGCTCCGAGGCGCTGCGCCAGGCGGCGATGGACGTGCATGGCCGGGCCATGCAGAACTGA

Protein Properties

Protein Residues:

467

Protein Molecular Weight:

49.7 kDa

Protein Theoretical pI:

5.82

Hydropathicity (GRAVY score):

-0.021

Charge at pH 7 (predicted):

-7.54

Protein Sequence:

>PA4829
MMESYDVIVIGAGPGGYNAAIRAGQLGLKVACVEGRETLGGTCLNVGCMPSKALLHASELYAAASGGEFARLGIRVSPELDLAQMMKQKDESVAALTRGVEFLFRKHKVQWIKGWARLQGEGRVGVALADGGHAQLEARDIVIATGSEPAPLPGVPVDNQRILDSTGALELVEVPRHLVVIGAGVIGLELGSVWRRLGAQVTVLEYLERICPGLDGETARTLQRALTRQGMRFRLGTRVVAARSGEQGVELDLQPAAGGATESLQADYVLVAIGRRPYTEGLGLETVGLASDRRGMLENQGQRSAAPGVWVIGDVTSGPMLAHKAEEEAIVCIERIAGHAAEMNAEVIPSVIYTQPEVASVGLGEEQLQAARREYKVGRFPFSANSRAKINHESEGFIKILSDARSDQVLGVHMIGPGVSEMIGEACVAMEFSASAEDLALTCHPHPTRSEALRQAAMDVHGRAMQN

References

External Links:

Resource	Link
Genome ID:	PA4829
Entrez Gene ID:	882254
NCBI Protein ID:	15600022

General Reference:

PaperBLAST - Find papers about PA4829 and its homologs

dihydrolipoamide dehydrogenase 3 LPD-3 (PA4829)