| Identification |
| Name: |
Octanoyltransferase |
| Synonyms: |
- Lipoate-protein ligase B
- Lipoyl/octanoyl transferase
- Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
|
| Gene Name: |
lipB |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in catalytic activity |
| Specific Function: |
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate |
| Cellular Location: |
Cytoplasm (Potential) |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
Octanoyl-[acp] | + | Apoprotein | + | Octanoyl-[acp] | + | Protein | ↔ | Protein N6-(octanoyl)lysine | + | Acyl-carrier protein | + | Protein N6-(octanoyl)lysine | + | Acyl-carrier protein |
| Octanoyl-[acp] + Apoprotein + Octanoyl-[acp] + Protein ↔ Protein N6-(octanoyl)lysine + Acyl-carrier protein + Protein N6-(octanoyl)lysine + Acyl-carrier protein ReactionCard | |
Lipoyl-[acp] | + | Apoprotein | ↔ | Protein N6-(lipoyl)lysine | + | Acyl-carrier protein |
| Lipoyl-[acp] + Apoprotein ↔ Protein N6-(lipoyl)lysine + Acyl-carrier protein ReactionCard |
|
| SMPDB Reactions: |
|
Octanoyl-[acyl-carrier protein] | + | apoprotein | → | [acyl carrier protein] | + | Protein N6-(octanoyl)lysine |
| Octanoyl-[acyl-carrier protein] + apoprotein → [acyl carrier protein] + Protein N6-(octanoyl)lysine ReactionCard | |
Lipoyl-ACP | + | apoprotein | → | Protein N6-(lipoyl)lysine | + | [ACP] |
| Lipoyl-ACP + apoprotein → Protein N6-(lipoyl)lysine + [ACP] ReactionCard | |
Octanoyl-[acyl-carrier protein] | + | a [lipoyl-carrier protein]-L-lysine | → |  | + | a holo-[acyl-carrier protein] | + | Protein N6-(octanoyl)lysine |
| Octanoyl-[acyl-carrier protein] + a [lipoyl-carrier protein]-L-lysine → Hydrogen ion + a holo-[acyl-carrier protein] + Protein N6-(octanoyl)lysine ReactionCard | |
an acetyl-[acp] | + | a [lipoyl-carrier protein]-L-lysine | → | a [lipoyl-carrier protein] N6-octanoyl-L-lysine | + | | + | a holo-[acyl-carrier protein] |
| an acetyl-[acp] + a [lipoyl-carrier protein]-L-lysine → a [lipoyl-carrier protein] N6-octanoyl-L-lysine + Hydrogen ion + a holo-[acyl-carrier protein] ReactionCard |
|
| PseudoCyc/BioCyc Reactions: |
|
| + | Octanoyl-ACP (n-C8:0ACP) | → | acyl carrier protein | + | octanoate (protein bound) |
| | |
Octanoyl-[acyl-carrier protein] | + | a [lipoyl-carrier protein]-L-lysine | → | | + | a holo-[acyl-carrier protein] | + | Protein N6-(octanoyl)lysine |
| Octanoyl-[acyl-carrier protein] + a [lipoyl-carrier protein]-L-lysine → Hydrogen ion + a holo-[acyl-carrier protein] + Protein N6-(octanoyl)lysine ReactionCard | | an octanoyl-[acp] + a [lipoyl-carrier protein] → a [lipoyl-carrier protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein] + H +ReactionCard | |
Gcv-H | → | Octanoylated-Gcv-H | + | |
| |
|
| Complex Reactions: |
|
| + | Octanoyl-ACP (n-C8:0ACP) | → | acyl carrier protein | + | octanoate (protein bound) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| acyltransferase activity | | catalytic activity | | octanoyltransferase activity | | transferase activity | | transferase activity, transferring acyl groups | | transferase activity, transferring acyl groups other than amino-acyl groups | | Process |
|---|
| cellular metabolic process | | coenzyme metabolic process | | cofactor metabolic process | | lipoate biosynthetic process | | lipoic acid biosynthetic process | | lipoic acid metabolic process | | macromolecule metabolic process | | macromolecule modification | | metabolic process | | protein modification process |
|
| Gene Properties |
| Locus tag: |
PA3997 |
| Strand: |
- |
| Entrez Gene ID: |
878952 |
| Accession: |
NP_252686.1 |
| GI: |
15599192 |
| Sequence start: |
4477974 |
| Sequence End: |
4478627 |
| Sequence Length: |
653 |
| Gene Sequence: |
>PA3997
ATGGGACTCGAGCTGGGCTTCCGTGAGCTCGGCGAGGTTCCCTACGAACCGACCTGGCATGCCATGCAGCGCTTCGTTGCCGAGCGCGACAAATCGGTAATGGACGAAGCCTGGCTGTTGCAGCACCCTGCGGTCTTCACCCAGGGGCAGGCCGGCAAGGCGGAGCATGTGCTGTTCCCCGGCGACATCCCGGTGATCCAGGTAGATCGCGGCGGCCAGGTGACCTACCACGGCCCCGGCCAGTTGGTCACCTACCTGCTGCTCGATGTCCGCCGCCTGGGACTGGGCGTGCGCGAGCTGGTCAGCCGGATCGAGCAGAGCCTGATCGGCCTGCTGGCGTCCTATGACGTGCAGGCCGTGGCCAAGCCGGACGCGCCGGGTGTCTACGTCGACGGGGCGAAGATCGCCTCCCTCGGCCTGCGCATCCGCAACGGCTGTTCCTTCCATGGCCTGGCGCTGAACCTGGACATGGACCTGCGACCGTTCCAACGAATCAATCCCTGCGGCTACGCCGGGATGCCCATGACCCAACTGCGCGACCTGGTTGGGCCGGTGGATTTTGCCGAGGTGTGTACCCGATTGCGCGCTGAGCTCGTCTCACGCCTTGGCTACGCTGAACAGAAGACCCTTACGGGCGGGATCGAACTGACATGA |
| Protein Properties |
| Protein Residues: |
217 |
| Protein Molecular Weight: |
23.9 kDa |
| Protein Theoretical pI: |
6.02 |
| Hydropathicity (GRAVY score): |
0.001 |
| Charge at pH 7 (predicted): |
-2.9 |
| Protein Sequence: |
>PA3997
MGLELGFRELGEVPYEPTWHAMQRFVAERDKSVMDEAWLLQHPAVFTQGQAGKAEHVLFPGDIPVIQVDRGGQVTYHGPGQLVTYLLLDVRRLGLGVRELVSRIEQSLIGLLASYDVQAVAKPDAPGVYVDGAKIASLGLRIRNGCSFHGLALNLDMDLRPFQRINPCGYAGMPMTQLRDLVGPVDFAEVCTRLRAELVSRLGYAEQKTLTGGIELT |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA3997 and its homologs
|
