2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (PA3666)

Identification
Name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Synonyms:
  • Tetrahydrodipicolinate N-succinyltransferase
  • THDP succinyltransferase
  • THP succinyltransferase
  • Tetrahydropicolinate succinylase
Gene Name: dapD
Enzyme Class:
Biological Properties
General Function: Involved in 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Specific Function: Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Water + Succinyl-CoA + Tetrahydrodipicolinate ↔ Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Succinyl-CoA + Tetrahydrodipicolinate + Water ↔ Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Water + Tetrahydrodipicolinate + Succinyl-CoA ↔ N-Succinyl-2-amino-6-ketopimelate + Coenzyme A
ReactionCard
SMPDB Reactions:
Thumb+Succinyl-CoA+Thumb+Thumb → Thumb+Thumb
(S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water + Succinyl-CoA → Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Water + Succinyl-CoA + Tetrahydrodipicolinate ↔ Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Water + Tetrahydrodipicolinate + Succinyl-CoA ↔ N-Succinyl-2-amino-6-ketopimelate + Coenzyme A
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006304(S)-2,3,4,5-tetrahydrodipicolinateMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB000835N-Succinyl-2-amino-6-ketopimelateMetaboCard
PAMDB000228Succinyl-CoAMetaboCard
PAMDB000840TetrahydrodipicolinateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
acyltransferase activity
catalytic activity
N-acyltransferase activity
N-succinyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
Process
aspartate family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
lysine biosynthetic process
lysine biosynthetic process via diaminopimelate
lysine metabolic process
metabolic process
Gene Properties
Locus tag: PA3666
Strand: +
Entrez Gene ID: 880584
Accession: NP_252356.1
GI: 15598862
Sequence start: 4104745
Sequence End: 4105779
Sequence Length: 1034
Gene Sequence: 
>PA3666
ATGTCGCAATCCCTGTTCAGCCTGGCCTTCGGCGTCGGCACCCAGAACCGCCAGGAAGCCTGGCTGGAAGTGTTCTACGCGCTGCCGCTGCTCAAGCCTTCGAGCGAAATCGTCGCCGCCGTCGCACCGATCCTTGGCTACGCAGCCGGCAACCAGGCGCTGACCTTCACTTCGCAGCAGGCCTACCAGTTGGCCGACGCCCTGAAGGGTATCGACGCCGCTCAGTCGGCCCTGCTCTCGCGCCTGGCGGAAAGCCAGAAGCCGCTGGTCGCCACCCTGTTGGCGGAAGACGCCGCGCCGTCCTCCACCGCGGAGGCCTACCTCAAGCTGCACCTGCTCTCCCACCGCCTGGTCAAGCCGCACGCTGTGAACCTGAGCGGCATCTTCCCGCTCCTGCCGAACGTGGCCTGGACCAATATCGGCGCGGTGGACCTGGCCGAACTGGCCGAACTGCAACTGGAAGCGCGACTGAAGGGCAAGCTGCTGGAAGTCTTCTCCGTCGACAAGTTCCCGAAGATGACCGACTACGTGGTCCCGGCCGGCGTACGCATCGCCGACACCGCCCGCGTGCGCCTGGGCGCCTACATCGGTGAAGGCACCACGGTGATGCACGAAGGTTTCGTCAACTTCAACGCCGGCACCGAAGGCCCGGGCATGATCGAAGGCCGCGTATCCGCCGGCGTGTTCGTCGGCAAGGGGTCGGACCTGGGCGGCGGCTGCTCGACCATGGGCACCCTTTCCGGTGGCGGCAACATCGTCATCAGCGTCGGCGAAGGCTGCCTGATCGGCGCCAACGCCGGCATCGGCATCCCGCTGGGCGATCGCAACATCGTCGAGGCCGGCCTGTACATCACCGCCGGCACCAAGGTCGCCCTGCTCGACGAGCAGAACGCCCTGGTGAAAGTGGTCAAGGCCCGCGACCTGGCCGGTCAGCCCGACCTGCTGTTCCGCCGCAACTCGCAGAACGGTGCGGTGGAGTGCAAGACCAACAAGACCGCCATCGAGCTGAACGAAGCGCTGCACGCGCACAACTGA
Protein Properties
Protein Residues: 344
Protein Molecular Weight: 36 kDa
Protein Theoretical pI: 5.97
Hydropathicity (GRAVY score): 0.208
Charge at pH 7 (predicted): -3.65
Protein Sequence: 
>PA3666
MSQSLFSLAFGVGTQNRQEAWLEVFYALPLLKPSSEIVAAVAPILGYAAGNQALTFTSQQAYQLADALKGIDAAQSALLSRLAESQKPLVATLLAEDAAPSSTAEAYLKLHLLSHRLVKPHAVNLSGIFPLLPNVAWTNIGAVDLAELAELQLEARLKGKLLEVFSVDKFPKMTDYVVPAGVRIADTARVRLGAYIGEGTTVMHEGFVNFNAGTEGPGMIEGRVSAGVFVGKGSDLGGGCSTMGTLSGGGNIVISVGEGCLIGANAGIGIPLGDRNIVEAGLYITAGTKVALLDEQNALVKVVKARDLAGQPDLLFRRNSQNGAVECKTNKTAIELNEALHAHN
References
External Links:
Resource Link
Genome ID: PA3666
Entrez Gene ID: 880584
NCBI Protein ID: 15598862
General Reference: PaperBLAST - Find papers about PA3666 and its homologs